Clinical trials: Regression
Post Spinal Anesthesia Shivering
Intrathecal DEX With Bupivacaine Inpost-spinal Shivering After CS.
This prospective, randomized, double-blind, placebo-controlled study to determine whether intrathecal dexmedetomidine, administered along with hyperbaric bupivacaine for covering Cesarean delivery decreases the incidence of…
- Trial name
- DEX (NCT06942000)
- Testing
- dexmedetomidine 3mcg group, dexmedetomidine 5mcg, preservative-free 0.9% saline.
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Treatment of Acne Vulgaris Grade II in a Short Period of Time.
Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples)
Sixty two subjects will take part in this study. The study is unic arm. The subjects used the product once and will be evaluated in the regression of pimples in the times 0,4,6,8 and 24 hours after application.
- Trial name
- NCT01260571
- Testing
- Benzoyl peroxide and sulfur
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Zurita Laboratorio Farmaceutico Ltda.
Drug Hypersensitivity
Predictive Models for Betalactam Allergy
Background: ß-lactam (BL) antibiotics represent the main cause of allergic reactions to drugs, inducing both immediate and non-immediate reactions.
- Trial name
- NCT03076749
- Testing
- Creating models for the diagnosis of BL allergy
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Montpellier
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Hypoxia, Erythropoiesis
Effects of Intermittent Hypoxia Training With Iron Supplementation on Red Blood Cells and Iron Levels in Trained Athletes
This study investigates how training under conditions of reduced oxygen (intermittent hypoxia) affects the body's ability to produce red blood cells and manage iron levels, compared to training under normal oxygen conditions.
- Conditions
- Hypoxia, Erythropoiesis, Iron Metabolism Disorders
- Trial name
- IHIT-IRON (NCT07720960)
- Testing
- Control group (CG), Hypoxia group (HG): trained at simulated altitudes between 4,450 and 5,850 m
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Néstor Vicente-Salar
Neoplasms
A Study of DSP-0509 in Patients With Advanced Solid Tumors to Determine the Safety and the Pharmacokinetic Profile
This is a multi-center, Phase 1 / 2 clinical study for patients with advanced solid tumors. The study consists of 2 treatment arms - a monotherapy arm and a combination arm.
- Trial name
- NCT03416335
- Testing
- DSP-0509, DSP-0509, Pembrolizumab
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Sumitomo Pharma America, Inc.
Secondary Hyperparathyroidism, End Stage Renal Disease
Safety and Effectiveness of Zemplar Injection in Decreasing iPTH Levels in Pediatric ESRD Subjects on Hemodialysis
The purpose of this study is to see if Zemplar, a vitamin D medication, safely and effectively decreases parathyroid hormone in children ages 2-20 with End Stage Renal Disease.
- Trial name
- NCT00053547
- Testing
- paricalcitol injection
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Abbott
Delirium
Decreasing Delirium Through Music
DDM is a study designed to Test the efficacy of personalized music therapy in reducing delirium incidence and severity among patients admitted to the Intensive Care Unit.
- Trial name
- DDM (NCT03095443)
- Testing
- Music Therapy - Personalized Playlist, Music Therapy - Standard Playlist, Attention Control
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Indiana University
Coronary Heart Disease, Arrhythmia
ECG and VCG in Dependence of Body Posture
The electrocardiogram (ECG) is an important diagnostic procedure in medicine mainly to detect circulation disorders and problems of the spread of the electrical heart impulse.
- Trial name
- EVER (NCT02094989)
- Testing
- posture dependence of VCG-ECG-transformation
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Tourniquet Hypertension
Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery
Knee pain is very common, and more people are having minor knee surgeries done through a small camera (arthroscopy), often as outpatients.
- Trial name
- torniquet (NCT06936410)
- Testing
- Lidocaine 2% Injectable Solution, Dexmedetomidine HCL Injection
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Cairo University
Smoking Cessation
The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers
The goal of this clinical trial is to evaluate effectiveness of using e-cigarettes as harm reduction strategy for smoking cessation and decreasing risk of diseases in heavy smokers.
- Trial name
- NCT05639790
- Testing
- Electronic cigarettes + Health Counselling, Health Counselling
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shenzhen Smoore Technology Limited
Bleeding During Myomectomy
Rectal Misoprostol Versus Sublingual Misoprostol Prior to Myomectomy
the aim of the study is To compare the effectiveness of rectally administered prostaglandin E1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before myomectomy to decrease blood loss…
- Trial name
- RM-SLM (NCT02716142)
- Testing
- rectal misoprostol, sublingual misoprostol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Gestational Trophoblastic Disease
Letrozole as a Prophylaxis From GTN for Complete Mole Patients
Prophylactic use of aromatase inhibitor is effective in decreasing the incidence of Gestational Trophoblastic Neoplasia (GTN) in patients with complete hydatidiform mole (CHM)
- Trial name
- NCT05203562
- Testing
- Suction evacuation, Letrozole tablets
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Zagazig University
Breast Cancer Survivor, Cancer Related Fatigue
Maximizing Energy and Reducing Fatigue in Breast Cancer Survivors
This study is testing a program called Maximizing Energy to see if it can help women who have finished breast cancer treatment manage their fatigue. The study has two main goals: 1.
- Trial name
- BCS_MAX (NCT06879522)
- Testing
- Maximizing Energy Intervention, Health Education
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Mechanical Ventilation
Decreasing Trigger Sensitivity Could Assist PEEP to Further Improve Regional Ventilation Distribution
In mechanically ventilated patients during supine position, alveolar collapse usually distributes in dependent lung region.Decrease of flow trigger sensitivity might improve homogeneous of tidal volume distribution.
- Trial name
- NCT03241654
- Testing
- flow trigger
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Advanced Melanoma
Immunologic Determinants of Response to Pembrolizumab (MK-3475) in Advanced Melanoma (MK-3475-161/KEYNOTE-161)
In this study, participants with advanced melanoma will be treated with pembrolizumab (MK-3475) and their tumors and blood will be analyzed for changes related to pembrolizumab therapy.
- Trial name
- NCT03407170
- Testing
- pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Merck Sharp & Dohme LLC
Gastrointestinal Cancer
Effectiveness of Low Dose Aspirin in Decreasing the Chance Getting Stomach and Intestine Cancer
In this study, researchers wanted to learn more about the effect of Aspirin taken as low dose (75 - 300 mg) in preventing stomach, colorectal and esophagus cancer.
- Trial name
- ENgAGE-HK (NCT04081831)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- Hong Kong
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Chronic Hepatitis C, Chronic Hepatitis B
The Regression of Liver Fibrosis and Risk for Hepatocellular Carcinoma (ROLFH) Study
This study aims to demonstrate that patients with chronic hepatitis C (CHC) and B (CHB) experiencing regression of liver cirrhosis after effective antiviral therapy have decreased risk for hepatocellular carcinoma (HCC).
- Trial name
- ROLFH (NCT01831037)
- Testing
- Regression of fibrosis, Specific risk factors related to hepatocellular carcinoma
- Where
- 4 sites in United States, Canada
- Sponsor
- University of Arkansas
Preoperative Anxiety
Comparing Virtual Reality (VR) to Non-VR for Decreasing Preoperative/Procedural Anxiety
The primary objective of the study is to utilize the modified Yale Preoperative Anxiety scale (mYPAS), a validated preoperative/procedural anxiety score, to measure preoperative anxiety via distraction in pediatric oncology…
- Trial name
- NCT05094141
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Localized Breast Cancer, Localized Prostate Cancer
Use of Organic Germanium or Placebo for the Prevention of Radiation Induced Fatigue
Participants will be diagnosed with localized prostate or breast cancer and be scheduled to undergo external beam radiation therapy.
- Conditions
- Localized Breast Cancer, Localized Prostate Cancer, Patients Receiving External Beam Radiotherapy
- Trial name
- NCT00651417
- Testing
- Organic Germanium
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Arizona Oncology Services