Clinical trials: Renal Dysfunction
Renal Insufficiency
Evaluation of the Risk of NSF Following MultiHance Injection in Patients With Chronic Kidney Disease
The objective of this long-term study is to prospectively compare the incidence of NSF in two cohorts (Cohort 1 - patients with moderate chronic kidney disease eGFR 30 to 59 and Cohort 2 - patients with severe chronic kidney…
- Trial name
- NCT00600951
- Where
- United States
- Volunteers
- 366 people
- Sponsor
- Bracco Diagnostics, Inc
Chronic Kidney Diseases
Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases (NIKE)
Chronic kidney disease (CKD) is a major health problem, with steadily increasing incidence and prevalence and the threat of a true "epidemic".
- Trial name
- NCT06325072
- Testing
- Conclusive genetic testing, Genotype-phenotype correlation for personalized diagnosis, Personalized study of variants of uncertain clinical significance (VUS) through functional studies on 3D organ-on-a-chip
- Where
- 4 sites in Italy
- Volunteers
- 160 people
- Sponsor
- Meyer Children's Hospital IRCCS
Acute Kidney Injury, Children
Renal Oxygen Saturation and Its Association With Acute Renal Injury
Peri-operative renal dysfunction is a major mortality and morbidity cause following cardiac and major vascular surgery. Although several intra-operative strategies are proposed for better outcomes, no effective and fast resulting…
- Conditions
- Acute Kidney Injury, Children, Cardiac Surgery
- Trial name
- NCT03608956
- Where
- Turkey (Türkiye)
- Sponsor
- Marmara University
Chronic Renal Insufficiency, Coronary Angiography
Contrast-medium Induced Nephrotoxicity in Patients Undergoing Coronary Angiography - Iodixanol Versus Iopromide
In the treatment of coronary heart disease which is the major cause of heart attack, direct mechanical treatment with catheters such as the coronary angiography, coronary balloon intervention and stenting intervention are the…
- Trial name
- NCT00823628
- Testing
- contrast agent (iopromide), contrast agent (iodixanol)
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- Seoul National University Bundang Hospital
End Stage Renal Disease
Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis
The present study plans to delineate the clinical, biochemical, sociological and psychological factors. involved in dialysis preparation, and their impact on dialysis initiation (DI), modality choice and prognosis.
- Trial name
- Peridialysis (NCT02488200)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Herlev Hospital
Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia
Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant
This phase II trial is studying how well etanercept works in treating young patients with idiopathic pneumonia syndrome after undergoing a donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Chronic Myelogenous Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Childhood Acute Myeloid Leukemia in Remission
- Trial name
- NCT00309907
- Testing
- etanercept, methylprednisolone
- Where
- 26 sites in United States
- Volunteers
- 39 people
- Sponsor
- Children's Oncology Group
Acute Renal Failure, Critical Illness
Metabolic Aspects of Citrate Anticoagulation in Renal Replacement Therapy
Citrate anticoagulation is associated with metabolic side effects which are linked to a portion of citrate reaching systemic circulation.
- Trial name
- Citrate (NCT01361581)
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
End Stage Renal Disease
Intravenous Immune Globulin (IVIG) Treatment Protocol in Kidney Transplant Patients
The purpose of this study is to test the clinical and laboratory observations of IVIG therapy in the highly sensitized patient. We will study the effects of patients treated with IVIG or Cytogam in combination with plasmaphoresis…
- Trial name
- NCT00586716
- Testing
- intravenous immune globulin
- Volunteers
- 22 people
- Sponsor
- Loma Linda University
End Stage Renal Disease
Frequent Hemodialysis Network: Daily Trial
The Frequent Hemodialysis Network (FHN) Daily Trial is a randomized controlled trial recruiting subjects from dialysis units associated with designated Clinical Centers in the U.S. and Canada and followed for 1 year.
- Trial name
- NCT00264758
- Testing
- Conventional hemodialysis, Frequent hemodialysis
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Urolithiasis, Urologic Diseases
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis
To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or…
- Conditions
- Urolithiasis, Urologic Diseases, Urinary Calculi, Urinary Obstruction
- Trial name
- STONE (NCT04594161)
- Testing
- Percutaneous Nephrostomy, Double J catheter
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Acute Kidney Injury, Drug Toxicity
Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate
This retrospective observational study will evaluate high-dose methotrexate patterns of use, supportive care measures used during high-dose methotrexate chemotherapy, along with the incidence of delayed elimination of…
- Trial name
- NCT05899751
- Testing
- High-dose methotrexate, Glucarpidase
- Where
- 5 sites in France, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Protherics Medicines Development Limited
End Stage Renal Disease (ESRD), Kidney Failure, Chronic
Probiotic and Synbiotic Supplements in Hemodialysis Patients
This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance…
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07531186
- Testing
- Natural Probiotic Supplement, Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Acute Kidney Injury
IMPROVE AKI Cluster-Randomized Trial
When a person has an imaging procedure that uses radio-contrast dye, there is a possibility of damage to that person's kidneys, which could result in being on dialysis or early death.
- Trial name
- IMPROVE-AKI (NCT03556293)
- Testing
- AKI Prevention Toolkit, Technical Assistance (TA), Virtual Learning Collaborative (VLC)
- Where
- 2 sites in United States
- Volunteers
- 10,252 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Diabetes Mellitus, Chronic Kidney Diseases
Audit and Feedback for General Practitioners in the Intego Network
Audit and feedback is an extensively investigated quality intervention, which according to the last Cochrane review leads to small but potentially important improvements in professional practice.
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Heart Failure
- Trial name
- NCT04388228
- Testing
- Extended audit and feedback in GPs electronic health record
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tine De Burghraeve
Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT)
A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD)
The main objective of this study is to evaluate the safety, efficacy and pharmacokinetics of paricalcitol oral solution in pediatric participants of ages 0 to 9 years with SHPT associated with stage 5 CKD receiving Peritoneal…
- Trial name
- NCT04064827
- Testing
- Paricalcitol
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 2 people
- Sponsor
- AbbVie
Acute Kidney Injury
Ciclosporin to Protect Renal Function In Cardiac Surgery
The purpose of this study is to evaluate the potential of ciclosporin in reducing risk and degree of acute kidney injury after cardiac surgery.
- Trial name
- CiPRICS (NCT02397213)
- Testing
- Ciclosporin
- Where
- Sweden
- Volunteers
- 155 people
- Sponsor
- Region Skane
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Usability and Tolerability of the Norditropin NordiFlex® Injection Device in Children Never Previously Treated With Growth Hormone
This study is conducted in Europe. The purpose of this study is to assess the impact on daily life for children new to using a growth hormone injection device.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Genetic Disorder, Turner Syndrome
- Trial name
- NCT01327924
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Disease
Peripheral Artery Disease in Regular Hemodialysis Patients
Recent studies have reinforced the association between high NLR and PAD in hemodialysis patients. This highlights the need for further studies to confirm its predictive value and determine optimal cut-off thresholds tailored to…
- Trial name
- NCT07179211
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences