Clinical trials: Replacement
Osteoarthritis
Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)
Clinical study to determine if there is a difference in hemoglobin level between patients undergoing total knee arthroplasty with and without platelet-rich plasma.
- Trial name
- NCT01075230
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Exactech
Total Hip Arthroplasty, Tranexamic Acid Administration
Combined Tranexamic Acid Use in Total Hip Replacement Surgery
This prospective study evaluates whether combined intravenous and topical administration of tranexamic acid (TXA) can safely reduce blood loss in patients undergoing primary total hip replacement surgery.
- Conditions
- Total Hip Arthroplasty, Tranexamic Acid Administration, Perioperative Blood Loss, Coagulation Monitoring Using ROTEM
- Trial name
- NCT07610863
- Testing
- Intravenous Tranexamic Acid, Combined Intravenous and Intraarticular Tranexamic Acid
- Where
- Czechia
- Volunteers
- 58 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Sepsis
Cytokine Removal by CRRT in Pediatric Sepsis
This pilot study will compare the effect of diffusive versus convective Continuous Renal Replacement Therapy (CRRT) in children with sepsis who require CRRT.
- Trial name
- NCT00537693
- Testing
- Continuous Renal Replacement Therapy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hemophilia A With Inhibitor, Haemophilia A Without Inhibitor
ATHN 7: Hemophilia Natural History Study
This is a real-world study of the safety of the treatments used for people with hemophilia. The study will follow people with hemophilia A or B from across the country for about 4 years as they receive treatment.
- Conditions
- Hemophilia A With Inhibitor, Haemophilia A Without Inhibitor, Hemophilia B With Inhibitor, Haemophilia B Without Inhibitor
- Trial name
- ATHN 7 (NCT03619863)
- Where
- 29 sites in United States
- Volunteers
- 395 people
- Sponsor
- American Thrombosis and Hemostasis Network
Spinal Fusion, Total Hip Replacement
Examining Effects of Spinal Fusion on Outcomes Following Total Hip Replacement
The purpose of the study is to explore the long term functional status of people who have had both a spinal fusion procedure and a total hip replacement.
- Trial name
- NCT03240484
- Testing
- X-Ray Imaging, Gait Analysis
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Ottawa Hospital Research Institute
Total Knee Replacement
Predictors of Poor Outcomes in 1038 Sigma Knees
The aim of the project is to ascertain the pre and intra operative predictors of poor outcomes in total knee replacement.
- Trial name
- NCT01515449
- Where
- United Kingdom
- Volunteers
- 1,038 people
- Sponsor
- NHS Fife
Gaucher Disease
Switchover Trial From Imiglucerase to Plant Cell Expressed Recombinant Human Glucocerebrosidase
This is a multi-center, open-label, switchover trial to assess the safety of taliglucerase alfa in 30 patients with Gaucher disease who are currently being treated with imiglucerase (Cerezyme®) enzyme replacement therapy.
- Trial name
- NCT00712348
- Testing
- Taliglucerase alfa
- Where
- 10 sites in United States, Australia and 4 more
- Volunteers
- 31 people
- Sponsor
- Pfizer
Aortic Valve Stenosis
ASAN Medical Center Aortic Valve Replacement Registry
This study evaluates the effectiveness and safety of surgical aortic valve replacement and transcatheter aortic valve replacement in aortic Stenosis.
- Trial name
- ASAN-AVR (NCT03298178)
- Testing
- TAVR, SAVR
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Ho-Jin Kim
Orthodontic Appliance
Speed of Premolar Extraction Space Closure: Every Visit Replacement of Working Archwire
The aims of this trial were to assess the effect of changing 0.019X0.025-inch SS working archwire monthly on the rate of space closure, to compare the frictional resistance of unchanged and new working archwires in-vitro, and to…
- Trial name
- NCT04549987
- Testing
- Space closure without changing working archwire monthly, Space closure withchanging working archwire monthly
- Where
- Jordan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Hunter Syndrome
Hunter Outcome Survey (HOS)
The purpose of this study is to collect data that will increase understanding of Hunter syndrome. The data from HOS may provide guidance to healthcare professionals about disease treatment options.
- Trial name
- HOS (NCT03292887)
- Where
- United States
- Volunteers
- 1,443 people
- Sponsor
- Shire
Mucopolysaccharidosis IVA, Morquio A Syndrome
Efficacy and Safety Study of BMN 110 for Morquio A Syndrome Patients Who Have Limited Ambulation
The primary objective of this study is to evaluate the effect of 2.0 mg/kg/week BMN 110 in a patient population that has limited ambulation, in a period of up to 144 weeks.
- Conditions
- Mucopolysaccharidosis IVA, Morquio A Syndrome, MPS IVA
- Trial name
- NCT01697319
- Testing
- BMN 110
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 16 people
- Sponsor
- BioMarin Pharmaceutical
Venous Thromboembolism (VTE), Total Joint Arthroplasty
Efficacy of Aspirin in Preventing Venous Thromboembolism
Efficacy of aspirin and enoxaparin in preventing venous tromboembolism was compared after total knee or hip arthroplasty.
- Conditions
- Venous Thromboembolism (VTE), Total Joint Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT06635317
- Testing
- Aspirin, enoxaparin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Aortic Valve Disease
SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy
This PAS is an observational, non-randomized, multi-center, single arm, clinical study to evaluate long term safety and effectiveness of the SJM™ Masters Series Hemodynamic Plus (HP) 15mm aortic mechanical heart valve (15…
- Trial name
- NCT03924661
- Testing
- Aortic Valve Replacement
- Where
- 13 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Immune Responses, Post Operative Recovery
Comparative Study Between the Effects of Deep Versus Moderate Neuromuscular Blockade on Postoperative Recovery and Immune Function in Patients Undergoing Total Hip Replacement Surgery.
. The investigators hypothesized that DNMB ( Deep NeuroMuscular Block) would yield superior postoperative recovery quality and attenuate the surgery-induced immune suppression compared to MNMB ( Moderate NeuroMuscular Block)in…
- Trial name
- NCT07870954
- Testing
- ToF ( Train of Four) Scan
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Arthroplasty, Replacement, Knee, Robotics
Comparison of Ambulatory and Functional Improvement by Morning Walk
The aim of this study is to determine the clinical efficacy and feasability of gait rehabilitation robot through approving functional improvement by an end-effector typed gait robot in patients underwent total knee arthroplasty.
- Trial name
- NCT03183856
- Testing
- Morning walk, no Morning walk
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Ulsan University Hospital
Right Ventricular Congenital Cardiopathies
Non Interventional Study on Pulmonary Valve Replacement by Thranscatheter Pulmonary Valve Melody™
Prospective, longitudinal, open-label, multicentre, observational, non-comparative national study using an exhaustive registry of implantations over a given period.
- Trial name
- Melody™FR (NCT02023775)
- Testing
- Melody valve implantation
- Where
- 10 sites in France
- Volunteers
- 409 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Arthroplasty, Replacement, Knee
Fitbit and Social Support in Knee Replacement Patients & Buddies
Patients undergoing knee replacement typically report improved health-related quality of life, increased physical function, and reduced pain.
- Trial name
- NCT03037619
- Testing
- Fitbit, Fitbit+Support
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Total Knee Replacement
Evaluation of Patellar Crepitus Following Total Knee Arthroplasty
Analyze clinical data for a group of subjects implanted with a new surgical device designed to reduce the incidence of patellar crepitus following PCL-substituting TKA and compare that to a control group of subjects implanted…
- Trial name
- NCT01340144
- Volunteers
- 1,250 people
- Sponsor
- Colorado Joint Replacement