Clinical trials: Respiratory Distress Neonatal
Hyaline Membrane Disease, Necrotizing Enterocolitis of Newborn
The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates
Hyaline membrane disease, now commonly called respiratory distress syndrome (RDS), and feeding intolerance, which can lead to necrotizing enterocolitis (NEC), are two key morbidities found in premature neonates which resulted in…
- Trial name
- NCT03366584
- Testing
- Beta carotene, Vitamin D3, Zinc
- Where
- Indonesia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Respiratory Distress Syndrome, Newborn, Premature Birth
SURFAXIN® Treatment for Prevention of Bronchopulmonary Dysplasia (BPD) in Very Low Birth Weight (VLBW) Infants.
SURFAXIN® (lucinactant) treatment will be examined in very low birth weight infants to prevent development of chronic lung disease, commonly known as bronchopulmonary dysplasia (BPD), in premature infants who have required…
- Conditions
- Respiratory Distress Syndrome, Newborn, Premature Birth, Bronchopulmonary Dysplasia
- Trial name
- NCT00215540
- Testing
- Lucinactant 175 mg/kg, Lucinactant 90 mg/kg
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Windtree Therapeutics
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
Respiratory Distress Syndrome, Newborn
Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress
Title of Study: A Prospective, Randomized, Multicenter Trial Comparing Synchronized Intermittent Mandatory Ventilation (SIMV) vs.
- Trial name
- NCT00486850
- Testing
- Extubation to Nasal IPPV
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Southern California
Respiratory Distress Syndrome
Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates
The primary objective of this study is to evaluate the safety and tolerability of aerosolized surfactant, specifically lucinactant for inhalation, administered in escalating inhaled doses to preterm neonates 29 to 34 weeks…
- Trial name
- NCT02074059
- Testing
- Lucinactant for Inhalation, nCPAP alone
- Where
- 11 sites in United States
- Volunteers
- 80 people
- Sponsor
- Windtree Therapeutics
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Infant Respiratory Distress Syndrome
Umbilical Vein Needle Catheterization for Endotracheal Intubation.
The investigators describe a simple and efficient method to give a premedication in the delivery room, using the umbilical vein, directly punctured through Wharton's jelly.
- Trial name
- Intubation (NCT03359993)
- Testing
- Premedication of intubation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hôpital NOVO
Respiratory Distress of Newborn
Lung Ultrasound - Prospective Study
The goal of this clinical trial is to determine whether lung ultrasound can predict extubation success in neonates with respiratory distress. Participants will undergo a lung ultrasound pre- and post-extubation.
- Trial name
- NCT06140615
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants
Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure
Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management.
- Conditions
- Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
- Trial name
- NCT06446453
- Testing
- Echography-guided Surfactant THERapy (ESTHER)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Connecticut Children's Medical Center
Respiratory Distress
The Smell of Breast Milk and Therapeutic Positions in Comfort
Before starting the data collection process, a pilot study was conducted with 10 preterm newborns, five in the safe swaddling group and five in the control group, to evaluate the comprehensibility of the questionnaire form and…
- Trial name
- NCT06826053
- Testing
- Therapeutic position, Therapeutic position + smell breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Karamanoğlu Mehmetbey University
Neonatal Respiratory Distress
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure
The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants.
- Trial name
- NCT04051762
- Testing
- High flow nasal cannula vs. Nasal continuous positive airway pressure
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ramy Saleh Morsy
Respiratory Distress Syndrome, Newborn
A Safety and Efficacy Study of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks Gestational Age
This study is to evaluate the safety and efficacy of lucinactant for inhalation in conjunction with nCPAP, in comparison to nCPAP alone, in preterm neonates with RDS, as assessed by the incidence of and time to respiratory…
- Trial name
- NCT04264156
- Testing
- Lucinactant for Inhalation, nCPAP Only
- Where
- 3 sites in Poland
- Volunteers
- 12 people
- Sponsor
- Windtree Therapeutics
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Speed of Lung Inflation During Ventilation of Extremely Preterm Infants
Babies born extremely preterm (<28 weeks of pregnancy) require support to breathe. Some babies require help to breathe from a breathing machine (mechanical ventilator). While this keeps babies alive, it may damage their lungs.
- Trial name
- FLOW-VENT (NCT07101419)
- Testing
- Long PRT, Short PRT
- Where
- 3 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Murdoch Childrens Research Institute
Respiratory Distress Syndrome, Newborn
Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants (LUNG Study)
The investigators hypothesized that the use of lung ultrasound (LU) for measuring RDS severity and deciding surfactant treatment thresholds might decrease the incidence of early and late sequelae in the study group.
- Trial name
- LUNG (NCT05198375)
- Testing
- Lung ultrasound score (LUS)
- Where
- 18 sites in Italy, Spain
- Volunteers
- 411 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Prematurity, Respiratory Distress Syndrome
Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants
Approval of surfactant by the FDA in 1989 for the treatment of Respiratory Distress Syndrome (RDS) in premature infants greatly improved survival rates.
- Conditions
- Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
- Trial name
- CAST (NCT00767039)
- Testing
- Survanta (beractant), Curosurf (poractant)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Alan Fujii
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Neonatal Respiratory Distress, Preterm Birth
Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born Between 32 Weeks of Amenorrhea and 36 Weeks Plus 6 Days of Amenorrhea, Hospitalized in the Neonatal Pediatrics and Intensive Care Units of the Dijon University Hospital
Monocentric study carried out in the Neonatal and Intensive Care Units of the Dijon University Hospital. The objective is to evaluate the feasibility of performing a pulmonary ultrasound within 6 hours after admission in…
- Trial name
- REchoPP (NCT05737095)
- Testing
- Pulmonary ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diaphragm Ultrasound, Electrical Cardiometry
Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates
This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.
- Conditions
- Diaphragm Ultrasound, Electrical Cardiometry, Non Invasive Ventilation (NIV), RDS of Prematurity
- Trial name
- NCT07148102
- Testing
- Diaphragmatic US, EC
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Lamiaa Khaled Zidan
Bronchopulmonary Disease
Preterm Lung Patient Registry
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival.
- Trial name
- NCT00951366
- Testing
- Patient Registry
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Boston Children's Hospital