Clinical trials: Respiratory Failure, ICU
Respiratory Syncytial Virus
Prospective Pilot Clinical Trial of Azithromycin Treatment In Respiratory Syncytial Virus (RSV)- Induced Respiratory Failure In Children
This randomized, double-blind, placebo-controlled phase 2 trial will be conducted at a single tertiary pediatric intensive care unit (PICU).
- Trial name
- NCT02707523
- Testing
- Azithromycin 10 mg, Azithromycin 20mg
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
COVID19, Acute Renal Failure
The Effect of the Severity of COVID-19 Disease on the Incidence of Acute Renal Failure in ICU
Aim of the study is to determinate the frequency of acute renal failure in COVID-19 patients, its relationship with the severity of COVID-19 disease in ICU, and the ability to take precautions against these factors.
- Trial name
- NCT04799600
- Testing
- BRESCİA-COVİD Respiratory Severity Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Acute Respiratory Distress Syndrome in Children
PROSpect: Prone and Oscillation Pediatric Clinical Trial
Severe pediatric acute respiratory distress syndrome (PARDS) is a life-threatening and frequent problem experienced by thousands of children each year.
- Trial name
- NCT03896763
- Testing
- Either supine or prone positioning and either CMV or HFOV
- Where
- 49 sites in United States, Argentina and 13 more
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania
Acute Respiratory Failure
Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure
Electrical impedance tomography (EIT) is a non-invasive, bedside monitoring technique that provides continuous, real-time information about the regional distribution of the ventilation.
- Trial name
- PELUCHE1 (NCT05347563)
- Testing
- Electrical impedance tomography
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Failure, Mechanical Ventilation Complication
Patient-ventilator Asynchrony During Mechanical Non-Invasive Assisted-ventilation in Pediatric Patients (NavPed-NI)
The purpose of this study is to document the prevalence and type of asynchronies incidence during non-invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-NI (NCT01238757)
- Testing
- Non-invasive Ventilation under Pressure Support, Non-Invasive ventilation under NAVA
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Geneva
Intensive Care Unit, Mortality
Analysis of the Evolution of Mortality in an Intensive Care Unit
The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical…
- Conditions
- Intensive Care Unit, Mortality, Epidemiology, Respiration, Artificial
- Trial name
- NCT05261607
- Where
- Spain
- Volunteers
- 27,463 people
- Sponsor
- Hospital Universitario Getafe
Acute Respiratory Distress Syndrome, Pneumonia in Children
Using Artificial Intelligence To Improve Ventilator Settings For Intensive Care Patients
This observational study aims to determine whether an AI-assisted decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU, compared to standard…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients)
- Trial name
- NCT07592039
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Wu Rongzhou
Acute Respiratory Distress Syndrome, Severe Pneumonia
One Year Follow-ups of Patients Admitted to Spanish Intensive Care Units Due to COVID-19
The latest epidemiological data published from Chine reports that up to 30% of hospital-admitted patients required admission to intensive care units (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Severe Pneumonia, Respiratory Failure
- Trial name
- NCT04457505
- Where
- 31 sites in Spain
- Volunteers
- 8,500 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Critical Illness, Sepsis
MICU Recovery Clinic
Summary: Emerging data demonstrate long-term morbidity and mortality in those who survive critical illness. However, there is no data regarding long-term follow-up for ICU survivors.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, ARDS
- Trial name
- NCT02560129
- Testing
- Questionnaires, Physical and Cognitive Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pediatric Respiratory Diseases, Respiratory Failure
Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.
The purpose of this study is to determine the utility of point-of-care lung ultrasound (POC-LUS) in identifying the etiology of acute respiratory failure in pediatric patients admitted to the pediatric intensive care unit.
- Trial name
- NCT03744169
- Testing
- Lung ultrasound, Clinical exam, Chest x-ray
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Wisconsin, Madison
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Sedation
Safety And Efficacy Of Dexmedetomidine Sedation In Intubated Mechanically Ventilated Infants With Respiratory Failure
Dexmedetomidine is a highly selective α2-agonist with hypnotic, analgesic, and anxiolytic properties. Despite off-label administration, dexmedetomidine has found a niche in critically ill mechanically ventilated neonates and…
- Trial name
- DEXinPICU (NCT02996058)
- Testing
- Dexmedetomidine 0.35µg/kg /h, Dexmedetomidine 0.5µg/kg /h
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Respiratory Syncytial Virus Infections
Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix…
- Trial name
- NCT05026749
- Testing
- AZM Group, Control Group
- Where
- 15 sites in United States
- Volunteers
- 370 people
- Sponsor
- University of Alabama at Birmingham
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
Acute Respiratory Failure (ARF), Non Invasive Ventilation (NIV)
Music Therapy During NIV Implantation in Pediatric Intensive Care Units
Non-invasive ventilation makes it possible to avoid intubation and improve patients' quality of life. However, pain is associated with discomfort and could lead to failure of this technique.
- Trial name
- MusiNIV (NCT06848218)
- Testing
- Music Therapy, Setting Up NIV
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Acute Respiratory Failure
Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution.
- Trial name
- PELUCHE 2 (NCT07532811)
- Testing
- Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon