Clinical trials: Respiratory Failure, ICU
Muscle Weakness, Critical Illness
Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients
The investigators hypothesize that by applying a validated algorithm to accomplish early mobilization in surgical intensive care unit (ICU) patients, these patients will achieve a higher level of mobility which translates to…
- Conditions
- Muscle Weakness, Critical Illness, Respiratory Insufficiency
- Trial name
- mSOMS (NCT01363102)
- Testing
- SOMS
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Patient-Ventilator Asynchrony, Mechanical Ventilation Complication
Nurse Education to Reduce Patient-Ventilator Asynchrony in the PICU
A prospective cluster-randomized quality improvement trial was conducted to evaluate whether a structured nurse education program on ventilator waveform interpretation and alarm management reduces patient-ventilator asynchrony in…
- Conditions
- Patient-Ventilator Asynchrony, Mechanical Ventilation Complication, Nurse Education
- Trial name
- NCT07273487
- Testing
- Nurse Education on Ventilator Waveform and Alarm Management
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Respiratory Failure, Cardiac Event
A Randomized Controlled Trial of a Video Decision Aid in the ICU
Randomized Controlled Trial of a Video Decision Aid in the ICU in surrogates of admitted patients.
- Trial name
- VIDEO (NCT01776333)
- Testing
- video decision aid
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Respiratory Insufficiency
Effect of Physiotherapy Methods on Functional and Respiratory Outcomes in ICU Patients With Respiratory Failure
The aim of the biomedical study is to assess the changes in functional and qualitative indicators of critically ill patients with respiratory failure by applying different physiotherapy methods.
- Trial name
- NCT06912308
- Testing
- Active Physiotherapy, Passive Physiotherapy
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Laura Rutkauskienė
Positive-Pressure Respirations, Respiratory Failure
Inferior Vena Cava Indexes in Positive Pressure Supports
Collapsibility (CI-IVC), distensibility (dIVC) and delta (ΔIVC) indices, which are dynamic measures of inferior vena cava (IVC) diameter, are used to assess the intravascular volume status in critically ill patients.
- Trial name
- NCT03452046
- Testing
- IVC diametres
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Tepecik Training and Research Hospital
Respiratory Failure
Sleep Quality in Mechanically Ventilated Patients
Patients requiring mechanical ventilation in the ICU will undergo three consecutive nights of polysomnography to record sleep patterns while receiving three modes of mechanical ventilation; Proportional assist ventilation (PAV)…
- Trial name
- NCT01410149
- Testing
- PAV, PSV, ACV
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Respiratory Failure, Tracheostomy Complication
Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Lausanne ICU
This retrospective study aims to study characteristics of patients tracheotomized in the Lausanne ICU, both overall and by primary reasons of intubation.
- Trial name
- NCT04987398
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Piquilloud Imboden Lise
Lung Edema
Heparin-binding Protein and Lungedema in ICU Patients.
The goal of this single center observational cohort study is to investigate the relationship between physiological measures of lung oedema, and the biomarker Heparin-binding Protein (HBP).
- Trial name
- NCT07434908
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Umeå University
Respiratory Failure
Negative Pressure Ventilation Imapcts Weaning Ventilator In Medical Intensive Care Units (ICUs)
This is a Quasi-experimental research design. The subjects are limited in intensive care unit within north medical center hospital. All subjects depend on ventilator and receive weaning plans.
- Trial name
- NCT01155596
- Testing
- negative pressure ventilator use
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Respiratory Insufficiency, Metabolic Disease
Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?
Objective: Arterial blood gas (ABG) is essential in the clinical assessment of potential acutely ill patients venous to arterial conversion (v-TAC), a mathematical method, has recently been developed to convert peripheral venous…
- Conditions
- Respiratory Insufficiency, Metabolic Disease, Acidosis, Alkalosis
- Trial name
- NCT03309423
- Testing
- venous to arterial conversion (v-TAC)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aalborg University
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Nasal High Flow Therapy, Intensive Care Unit
High Flow Therapy in ICUs Across Ibero America
The study aims to describe the use of Nasal High Flow (NHF) in the intensive care units of participating centers in Iberoamerica.
- Conditions
- Nasal High Flow Therapy, Intensive Care Unit, Ventilatory Failure, Hypoxia
- Trial name
- T-Calfi (NCT03364946)
- Testing
- No intervention
- Where
- 9 sites in Colombia, Dominican Republic and 2 more
- Volunteers
- 255 people
- Sponsor
- Fundación Santa Fe de Bogota
Early Acute Respiratory Failure
Early Non-invasive Ventilation Outside the Intensive Care Unit
A large multicentre, randomized, controlled trial to demonstrate that non invasive ventilation given at an early stage of acute respiratory failure (ARF) outside the intensive care unit (ICU) can prevent the deterioration of ARF…
- Trial name
- NAVIGATE (NCT01572337)
- Testing
- Non-invasive ventilation, Standard care
- Where
- 14 sites in Greece, Italy and 1 more
- Volunteers
- 520 people
- Sponsor
- Università Vita-Salute San Raffaele
Sepsis, Sepsis Bacterial
Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis
This observational cohort study aims to compare clinical outcomes and inflammatory responses between patients with viral sepsis, specifically COVID-19-associated sepsis, and those with bacterial sepsis.
- Conditions
- Sepsis, Sepsis Bacterial, Viral Sepsis, Inflammatory Response
- Trial name
- NCT06491966
- Testing
- observation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sichuan Provincial People's Hospital
Acute Respiratory Failure
NAVA Unloading - Effects on Distribution of Ventilation
Title: Reduced Unloading in NAVA Improves distribution of Ventilation in ICU patients. Objectives: 1. To investigate if NAVA targeted to moderate respiratory muscular unloading results in redistribution of ventilation to the…
- Trial name
- NCT02711722
- Testing
- Neurally adjusted ventilatory assist, PScli1, PScli2
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska University Hospital
Acute Respiratory Failure, Caregiving Stress
Investigating Dyadic Expectations About ARF Survivorship (IDEAS)
The purpose of this observational study is to understand how adults who survive acute respiratory failure (ARF) and the people (usually family) who support ARF survivors after returning home think about the first 6 months of…
- Conditions
- Acute Respiratory Failure, Caregiving Stress, Mental Health Issue
- Trial name
- IDEAS (NCT06401239)
- Testing
- Dyadic expectations about the ARF survivor's perceived health 6 months after hospital discharge, Self-efficacy, Concordant expectations/shared appraisal of ARF survivor's health 6 months after hospital discharge
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Johns Hopkins University
Respiratory Failure
Non Invasive Ventilation After Cardiac Surgery
Patients with respiratory failure following cardiac surgery are randomized to receive standard therapy versus non invasive ventilation.
- Trial name
- CPAP-CCH (NCT01249794)
- Testing
- non invasive ventilation
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Mechanical Ventilation, Patient-Ventilator Asynchrony
Patient-Ventilator Asynchrony: Occurence and Clinical Impact in Usual Care
The goal of this observational study is to unravel the occurence, impact and relations of Patient-Ventilator Aynchrony (PVA) in mechanically ventilated patients.
- Trial name
- PVA-detection (NCT07624786)
- Testing
- PVA classification software
- Where
- 3 sites in Netherlands
- Volunteers
- 110 people
- Sponsor
- Erasmus Medical Center