Clinical trials: Respiratory Function
Pregnancy Related, Tobacco Smoking
Effects of Prenatal Tobacco Smoke Exposure on Lung Function and Respiratory Epithelium Functionality in Newborns
Despite public campaigns to prevent cigarette smoking, it's about 20% of women who keep on smoking during pregnancy, exposing their fetus to prenatal tobacco adverse effects.
- Conditions
- Pregnancy Related, Tobacco Smoking, Lung Smokers, Newborn
- Trial name
- NCT03047967
- Testing
- lung function tests, Nasal brushing
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Sleep Apnea, Obstructive, Insomnia
The IPAD Cohort Study: Insomnia and Positive Airway Pressure Adherence in Children and Adolescents
Positive Airway Pressure (PAP) is a treatment used to help people with sleep-disordered breathing, particularly those with obstructive sleep apnea (OSA).
- Trial name
- IPAD (NCT07176767)
- Testing
- Positive airway pressure therapy
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Lena Xiao
Pediatric Obstructive Sleep Apnea
Pediatric Obstructive Sleep Apnea Among Dental Interns in Egyptian Universities
Pediatric obstructive sleep apnea (OSA) is a common yet underdiagnosed sleep-related breathing disorder in children that may result in serious health and behavioral complications if left untreated.
- Trial name
- NCT07604831
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obstructive Sleep Apnea, Nasal Congestion
Effect of Heated Humidity With Thermosmart™ Compared to an Intranasal Steroid in Improving Compliance and Nasal Symptoms in Patients Using Continuous Positive Airway Pressure
1. CPAP compliance will be significantly higher in both the heated humidity with Thermosmart™ and the nasal steroid phases compared to the double placebo phase. 2.
- Conditions
- Obstructive Sleep Apnea, Nasal Congestion, Sinus Congestion
- Trial name
- Thermosmart (NCT00665977)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Clayton Sleep Insititute
Asthma in Children
Effect of a Daily Text Reminder on Asthma Medication Use, Symptom Control, and Lung Function in Children
The goal of this clinical trial is to learn if a daily text reminder ("AdhasText") can help children with asthma use their inhalers regularly, control their symptoms, and improve their lung function.
- Trial name
- NCT07053839
- Testing
- Daily Text Reminder
- Where
- Peru
- Volunteers
- 64 people
- Sponsor
- ROXANA AZNARAN TORRES
Respiratory Disease, Healthy
Optimization of Exhaled Biomarker Collection and Analysis
This is an exploratory study designed to optimize, standardize, and validate novel breath biomarkers; there are no objective endpoints.
- Trial name
- EBC (NCT05322785)
- Testing
- Breath collection
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pierre Robin Syndrome
Early Treatment Outcomes in Pierre-Robin-Like Phenotype
In a longitudinal cohort study, we want to assess the effect of the pre-epiglottic baton plate, the main treatment approach currently used in Germany for Pierre-Robin-Like phenotype, on upper airway obstruction and failure to…
- Trial name
- NCT02266043
- Testing
- Pre-epiglottic baton plate (PEBP)
- Where
- 3 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
COPD Exacerbation
Oral Prednisolone in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of systematic administration of oral prednisolone (1mg/Kg/day) as an add on therapy in Chronic Obstructive Pulmonary Disease (COPD) patients admitted to intensive care unit (ICU) for severe exacerbation of COPD.
- Trial name
- NCT01353235
- Testing
- Prednisolone, usual care
- Where
- Tunisia
- Volunteers
- 317 people
- Sponsor
- Fekri Abroug
Brain Injury
Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.
Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.
- Trial name
- GODWEAN (NCT02235376)
- Testing
- weaning trial of mechanical ventilation
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Burns, Respiratory Function Impaired
Inspiratory Muscle Training in Children With Chest Burn
8 weeks of inspiratory muscle training combined with a pulmonary rehabilitation program increases respiratory muscle strength, pulmonary function, functional capacity, and quality of life in chest burned children.
- Conditions
- Burns, Respiratory Function Impaired, Children
- Trial name
- chestburn (NCT05603507)
- Testing
- inspiratory muscle training, pulmonary rehabilitation
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Qassim University
Respiratory Distress Syndrome, Newborn, Infant, Premature
Neural Control of Non-invasive Ventilation in the Preterm
The present study will use a new type of respirator in premature babies who need help with their breathing. This new respirator uses signals from the baby's diaphragm - the most important breathing muscle - to control the timing…
- Trial name
- NCT00368485
- Testing
- Neurally Controlled Mechanical Ventilation
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ventilator Weaning, Child
The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning
To correlate the data obtained by Electrical impedance tomography (EIT) during the spontaneous breathing trials (SBT) on a T-piece, in children, with failure in the trial and Extubation failure.
- Conditions
- Ventilator Weaning, Child, Spontaneous Breathing Trial, Electrical Impedance Tomography
- Trial name
- NCT04011852
- Testing
- Electrical Impedance tomography
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Distress Syndrome, Newborn, Noninvasive Ventilation
RAM Cannula VS Short Nasal Prongs for Delivering NIPPV in Preterm Infants
Randomized control trial, Ram cannula VS short nasal prongs for delivering Non Invasive Positive Pressure Ventilation (NIPPV) for preterm infants
- Conditions
- Respiratory Distress Syndrome, Newborn, Noninvasive Ventilation, Infant, Premature, Intubation, Intratracheal
- Trial name
- RAMCAN (NCT03081611)
- Testing
- Ram cannula, Short nasal prongs
- Where
- Israel
- Volunteers
- 166 people
- Sponsor
- Rambam Health Care Campus
Respiratory Distress Syndrome
Facilitated Tucking Position During Endotracheal Suctioning
Aim of the present study The present study will aimed to determine the effect of facilitated tucking position during endotracheal suctioning on physiological criteria and behavioural responses of the preterm neonates.
- Trial name
- NCT06428916
- Testing
- tucking position during endotracheal suctioning
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Neonatal Respiratory Distress
Transference of Established Simulated Skills (TEST) Trial
This study aims to determine if skills learned in the simulation lab, specifically in managing mask leak during positive pressure ventilation (PPV), translate effectively to the delivery room.
- Trial name
- TEST (NCT06572033)
- Testing
- Simulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Respiratory Syncytial Virus (RSV)
Safety, Pharmacokinetics, and Antiviral Activity of Remdesivir (VEKLURY®) in Hospitalized Children With RSV
THAI-CARES RSV Study is a Phase II, open-label, multicenter, randomized controlled trial with a two-arm, parallel-group design. The study aims to assess the safety, efficacy, and acceptability of a five-day course of Remdesivir…
- Trial name
- THAI-CARES RSV (NCT06873633)
- Testing
- Remdesivir
- Where
- 8 sites in Thailand
- Volunteers
- 120 people
- Sponsor
- PENTA Foundation
Asthma in Children
Balloon Blowing Breathing Exercise in School-age Children With Asthma.
This study were to investigate the effects of balloon blowing breathing exercise on respiratory muscle strength and asthma symptoms in school-age children with asthma.
- Trial name
- NCT04874649
- Testing
- Balloon-blowing breathing, Sustained maximal inspiration breathing
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Ventilation, Respiratory Distress Syndrome
Observational Crossover Study Comparing Oxygenation and Ventilation Using SiPAP Versus CPAP in LBW Infants
Investigation of effects of SiPAP versus NCPAP on oxygenation and ventilation in LBW infants with respiratory distress. Our hypothesis is that the LBW infants will achieve the same level of oxygenation and improved ventilation…
- Trial name
- NCT01053455
- Testing
- SiPAP
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
COVID-19, Coronavirus Disease
Post COVID-19 Functional Status in Egypt
Since the outbreak of coronavirus disease - COVID-19 pandemic, most attention has focused on mode of transmission, clinical picture of the disease, treatment and prevention.
- Conditions
- COVID-19, Coronavirus Disease, SARS-CoV-2
- Trial name
- NCT04479293
- Testing
- Post COVID-19 Functional Satus Scale
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Acute Viral Bronchiolitis
High Flow Therapy vs Hypertonic Saline in Bronchiolitis
The purpose of this study is to demonstrate that heated, humidified, high-flow nasal cannula (HHHFNC) is superior to hypertonic saline solution (HSS) in the treatment of moderate acute viral bronchiolitis in infants in improving…
- Trial name
- NCT01873144
- Testing
- Epinephrine 1/1000, HSS 3%, HHHFNC
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Ministry of Health, Spain
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