Clinical trials: Respiratory Infection
HIV Infections, Syphilis
Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zimbabwe
The COVID-19 pandemic and response are likely to lead to severe unintended consequences for the prevention of mother-to-child transmission (PMTCT) of HIV and syphilis.
- Trial name
- NCT04782739
- Testing
- None - Descriptive study
- Where
- 2 sites in Zimbabwe
- Volunteers
- 30 people
- Sponsor
- University of Zimbabwe
Respiratory Tract Infections (RTI)
Real-Time Mass Spectrometry Breath Analysis for the Investigation of Respiratory Tract Infections
Lower respiratory tract infections (LRTIs) remain a major global health burden, with diagnosis often challenged by clinical heterogeneity, overlapping symptoms, difficulty in obtaining quality biological specimens and limitations…
- Trial name
- Respire (NCT07685275)
- Testing
- Breath analysis
- Where
- 3 sites in France
- Volunteers
- 450 people
- Sponsor
- Hopital Foch
COVID-19, Pneumonia
Study of the Efficacy and Safety of Ruxolitinib to Treat COVID-19 Pneumonia
The purpose of this study is to determine the safety and efficacy of the drug ruxolitinib in people diagnosed with COVID-19 pneumonia by determining the number of people whose conditions worsen (requiring machines to help with…
- Trial name
- NCT04331665
- Testing
- Ruxolitinib
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University Health Network, Toronto
Pulmonary Aspergillosis
Azole-resistance in Aspergillus
Prospective multi-center surveillance study on the prevalence of azole-resistant Aspergillus spp. in clinical isolates of patients with pulmonary colonization or invasive infections in Switzerland
- Trial name
- NCT03443336
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Psychiatric Disorder, Eating Disorders in Adolescence
Recrudescence of Eating Conduct Disorders and Covid-19
This qualitative study, combining psychiatric and anthropological perspectives, focused on the development and/or worsening of patients' eating disorders since Covid-19, as well as the experiences and perceptions of those around…
- Conditions
- Psychiatric Disorder, Eating Disorders in Adolescence, COVID-19
- Trial name
- TCA-Covid19 (NCT05780242)
- Testing
- Self-questionnaire Eating Attitudes, Situational Anxiety and Trait Anxiety, Beck Depression Inventory (BDI) scale
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Fondation Lenval
Respiratory Syncytial Virus Lower Respiratory Tract Infection
Dose Ranging Study of ALX-0171 in Infants Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
The primary objective is to evaluate the anti-viral effect and safety of different doses of inhaled ALX-0171 in subjects hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection (RSV LRTI).
- Trial name
- Respire (NCT02979431)
- Testing
- ALX-0171 3.0 mg/kg, ALX-0171 6.0 mg/kg, ALX-0171 9.0 mg/kg
- Where
- 74 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 180 people
- Sponsor
- Ablynx, a Sanofi company
COVID-19
The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms
This is a pilot, cross-sectional, sample collection study to characterize the immune response and intestinal microorganisms in people with and without COVID-19 antibodies and helminth infection.
- Trial name
- NCT04813328
- Where
- India
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bronchiolitis, Respiratory Disease
Isotonic Saline for Children With Bronchiolitis
The goal of this randomized clinical trial is to investigate the optimal supportive treatment of bronchiolitis in infants from 0-12 months of age.
- Conditions
- Bronchiolitis, Respiratory Disease, Asthma in Children, Viral Infection
- Trial name
- NCT05902702
- Testing
- Nebulized isotonic saline, Nasal irrigation with isotonic saline
- Volunteers
- 300 people
- Sponsor
- Slagelse Hospital
Pneumocystis Pneumonia
Effects and Safety of Caspofungin and Corticosteroids in Pneumocystis Pneumonia in Non-HIV Patients
Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population.
- Trial name
- NCT02603575
- Testing
- caspofungin, corticosteroids, Sulfanilamides
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
RSV Infection
Evaluating the Infectivity, Safety and Immunogenicity of Respiratory Syncytial Virus Vaccines, RSV 6120/∆NS1 and RSV 6120/F1/G2/∆NS1, in RSV-Seropositive Children and RSV-Seronegative Infants and Children
The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of a single dose of recombinant, live-attenuated respiratory syncytial virus (RSV) vaccines (RSV 6120/∆NS1 or RSV 6120/F1/G2/∆NS1) in…
- Trial name
- NCT03596801
- Testing
- RSV 6120/∆NS1, RSV 6120/F1/G2/∆NS1
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Respiratory Infection
Oral Symptoms of COVID-19 Among Infected Medical Doctors
Oral symptoms of corona virus disease have been reported by many studies. The lack of direct contact between the dentist and the patient during the active disease presented an obstacle to build a strong body of evidence.
- Trial name
- NCT05697081
- Testing
- Medical doctors infected with COVID-19
- Where
- Egypt
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Diabetes Mellitus, Type 1
Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity
Investigator initiated, randomised, placebo-controlled, double-blind, multi-centre primary intervention study to assess whether daily administration of B.
- Trial name
- SINT1A (NCT04769037)
- Testing
- B. infantis
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 1,149 people, healthy volunteers welcome
- Sponsor
- Helmholtz Zentrum München
Bronchiolitis
Comparison of Two Methods of Immunoprophylaxis Against RSV in Term Newborns
Bronchiolitis is a lower respiratory tract infection, extremely common in pediatrics, and potentially serious. Bronchiolitis affects nearly 30% of infants under 2 years old each year, representing approximately 480,000 cases…
- Trial name
- Abrystus (NCT07251972)
- Testing
- to compare vaccine and monoclonal antibody
- Where
- France
- Volunteers
- 1,137 people
- Sponsor
- Jean-Michel HASCOET
Pneumonia, Acute Respiratory Disease
Effectiveness of the Pneumococcal Polysaccharide Vaccine in Military Recruits
The primary objective is to determine the clinical benefit of employing the 23-valent pneumococcal vaccine among US military trainees. Secondary objectives include: determining the etiology of clinical pneumonia among U.S.
- Trial name
- NCT02079701
- Testing
- 23-valent pneumococcal vaccine
- Where
- 5 sites in United States
- Volunteers
- 152,723 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
SARS-CoV Infection
A Feasibility Study Using the CoronaCheck Device to Identify Incident Cases of SARS CoV-2 Covid-19
Point of care testing is urgently required to enable the immediate detection of SARS-CoV-2 infection to allow effective transmission prevention precautions to succeed.
- Trial name
- NCT04742712
- Testing
- CoronaCheck Device
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Upper Respiratory Infection, Pediatric Surgical Patients
PRAE and Asymptomatic and Symptomatic URI Patients
The objective of this study is to determine the prevalence of asymptomatic viral carriers among healthy surgical patients and to describe the demographic and clinical characteristics of these patients.
- Conditions
- Upper Respiratory Infection, Pediatric Surgical Patients, Perioperative Respiratory Adverse Events
- Trial name
- NCT07816822
- Testing
- Mid-turbinate nasal swab
- Volunteers
- 300 people
- Sponsor
- Brittany Willer
Asthma
Vitamin D in Preschoolers With Viral-induced Asthma
In this 7-month randomized controlled trial, children aged 1-6 years with asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual clinic visit.
- Trial name
- DIVA (NCT02197702)
- Testing
- vitamin D
- Where
- Canada
- Volunteers
- 47 people
- Sponsor
- St. Justine's Hospital
Respiratory Viral Infection
Study to Assess the Safety and Efficacy of ZX-7101A for Oral Suspension in Chinese Pediatric Participants 2 to 11 Years of Age With Influenza
The goal of this phase III study is to learn if ZX-7101A for oral suspension works to treat uncomplicated influenza in Pediatric Participants aged 2 to 11 years.
- Trial name
- ZX-7101A-214 (NCT07095257)
- Testing
- ZX-7101A for oral suspension, Oseltamivir phosphate for oral suspension
- Where
- 2 sites in China
- Volunteers
- 169 people
- Sponsor
- Nanjing Zenshine Pharmaceuticals
Asthma, Covid19
Impact of COVID19 on Asthma Patients in Spain
This research project aims to investigate the impact of COVID-19 on asthmatic patients, particularly focusing on whether the viral infection exacerbates asthma or affects control and lung function in the short to medium term.
- Trial name
- IMCAS (NCT05064501)
- Testing
- spirometry, Asthma control test
- Where
- 2 sites in Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Influenza
Study on a High-Dose Quadrivalent Influenza Vaccine Compared With Standard-Dose Quadrivalent Influenza Vaccine in Children 6 Months Through 35 Months of Age
The primary objective of the study was to compare the clinical efficacy of high-dose quadrivalent influenza vaccine (QIV-HD) to standard-dose quadrivalent influenza vaccine (QIV-SD) in participants 6 months through 35 months of…
- Trial name
- QHD00014 (NCT04544267)
- Testing
- Quadrivalent influenza vaccine, high-dose, Quadrivalent influenza vaccine, standard dose
- Where
- 10 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
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