Clinical trials: Respiratory Monitoring
Extraesophageal Reflux
Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic Option
The diagnostics of extraesophageal reflux (EER) is challenging. Currently, 24-h dual-probe esophageal pH monitoring or impedance is considered the best diagnostic method for EER.
- Trial name
- NCT03904758
- Testing
- Pepsin in saliva test
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Chronic Respiratory Failure, Non-invasive Ventilation
Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach
The aim of the data collection is to create an advanced reliable method to remotely monitor patient on chronic home non-invasive ventilation (NIV), both regarding ventilatory efficacy and patient comfort, both in the hospital and…
- Trial name
- NOCTIVENT (NCT05756387)
- Testing
- Non-invasive ventilation
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Diarrhoeal Disease, Respiratory Infection
Water Filters and Improved Cookstoves in Western Rwanda
DelAgua Health Rwanda (Implementation) Ltd. together with Rwanda Ministry of Health (MoH) are delivering an intervention, consisting on the free distribution of one advance water filter and one improved cookstove to all household…
- Conditions
- Diarrhoeal Disease, Respiratory Infection, Pneumonia
- Trial name
- NCT02239250
- Testing
- Water filter and cookstove
- Where
- Rwanda
- Volunteers
- 1,582 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Asthma
Self-care, Remote Monitoring and Elearning for Children and Young People With Asthma
Asthma is a long-term condition in children, often managed by general practitioners (GPs) in primary care but some children with asthma need hospital treatment and care by experienced paediatricians and nurses.
- Trial name
- ASTHMAME (NCT05972226)
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Duchenne Muscular Dystrophy (DMD)
E-monitoring of PULMonary Function in Patients With Duchenne Muscular Dystrophy at Home"
Duchenne muscular dystrophy (DMD) is the most common, progressive, irreversible muscular dystrophy. The pulmonary function is crucial for the duration of life in this disease.
- Trial name
- E-PULMoDMD (NCT05516745)
- Testing
- AioCare spirometer, telerehabiliation of the respiratory system
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Gdansk
Lung Diseases
The NIOMI Study: Non-Invasive Lung Oxygen Monitoring of Term Infants
Infants born prematurely e.g. before 28 weeks of gestational age have a 50% chance of developing neonatal respiratory distress syndrome (NRDS).
- Trial name
- NIOMI (NCT05851638)
- Testing
- Lung Oxygen measurement with GASMAS system
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College Cork
Cystic Fibrosis
Daily Monitoring of Respiratory Symptoms and Spirometry During ETI Treatment in Persons With Cystic Fibrosis.
The goal of this observational study is to provide optimal monitoring and support when initiating ETI treatment in eligible persons with cystic fibrosis (aged 12 y +) and to document on a daily basis, from 72 hours before the…
- Trial name
- NCT05599230
- Testing
- Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- CHC Montlegia
Asthma
Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)
This is a multicenter, randomized, double-blind, double-dummy, crossover study with two 2-week treatment periods separated by a 2-week wash-out period.
- Trial name
- NCT02730351
- Testing
- Fluticasone furoate/ Vilanterol 100 mcg/25 mcg, Fluticasone propionate 250 mcg
- Where
- 16 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- GlaxoSmithKline
Neonatal Encephalopathy
Transcutaneous Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Neonatal Encephalopathy
The aim of our study is to evaluate the feasibility of applying transcutaneous CO2 monitoring (tcPCO2) in neonates receiving therapeutic hypothermia and to quantify the agreement between tcPCO2 and PCO2 in this population with or…
- Trial name
- NCT04603547
- Testing
- Transcutaneous Carbon Dioxide Monitoring
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Pediatric Anesthesia, Laparoscopy
Electrical Impedance Tomography (EIT) Monitoring of Regional Ventilation During Pediatric Laparoscopy
The goal of this prospective, observational study is to describe EIT measurements at different time points during the perioperative period in healthy children undergoing laparoscopic surgery.
- Conditions
- Pediatric Anesthesia, Laparoscopy, Ventilation
- Trial name
- Pulmopneumo (NCT05823688)
- Testing
- Electrical Impedance Tomography
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Vittore Buzzi Children's Hospital
Cystic Fibrosis
Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI
This is an observational study for children with Cystic Fibrosis (CF) who are eligible based on their CF gene type. One group will be called the treatment group because they have the gene type (homozygous F508del) that makes them…
- Trial name
- NCT02848560
- Testing
- Hyperpolarized Xenon
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Catheter, Newborn, Infant, Disease
Evaluation of Intravascular Monitoring of Partial PRessure of Oxygen for Neonatal intensiVE Care Patients -2
The study is a non-blinded trial with one single intervention in sick newborn infants. The Neosense umbilical catheter will be used instead of the routinely used umbilical catheter on infants where the treating physician has…
- Conditions
- Catheter, Newborn, Infant, Disease, Lung Diseases
- Trial name
- IMPROVE-2 (NCT05433779)
- Testing
- Neosense Umbilical Catheter
- Where
- 5 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- Neosense Technologies
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Asthma
Vivatmo proTM EU-study: FeNO Monitoring in Asthmatic Patients Responding to ICS Treatment
This is a multi-center study to evaluate fractional exhaled nitric oxide (FeNO) measured with the Vivatmo pro in adult and pediatric subjects.
- Trial name
- NCT05553379
- Testing
- FeNO measurement
- Where
- 5 sites in Czechia, Germany
- Volunteers
- 48 people
- Sponsor
- Bosch Healthcare Solutions GmbH
Pediatric Acute Respiratory Distress Syndrome (PARDS)
Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome
Pediatric acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome, and dyspnea is its key symptom. Strenuous respiratory effort is a "second hit" for ARDS lungs, inducing changes in regional lung…
- Trial name
- NCT07750288
- Testing
- Noninvasive respiratory support, Transition from controlled to assisted mechanical ventilation, Weaning from mechanical ventilation
- Where
- Chile
- Volunteers
- 68 people
- Sponsor
- Universidad Nacional Andres Bello
Diabetes Mellitus, Hypertension
Evidence-based Laboratory Test Order Sets in Primary Care
Cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.
- Conditions
- Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Fatigue
- Trial name
- NCT02950142
- Testing
- CPOE with order sets for lab testing, CPOE without order sets for lab testing
- Where
- Belgium
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Otitis Media With Effusion, Laryngopharyngeal Reflux
Three Methods Used in the Diagnosis of EER in Children With OME
Detection of extraesophageal reflux (EER) in children with chronic otitis media with effusion (OME) using three different diagnostic methods and selection of the group of patients with severe EER who could potentially benefit…
- Trial name
- NCT02183961
- Testing
- Restech, Peptest, Detection of pepsin in adenoid specimen
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- University Hospital Ostrava
Apnea of Prematurity, Preterm Infant
Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants
Extremely preterm infants, born before 29 weeks of pregnancy, often face breathing difficulties, also known as respiratory events, due to their undeveloped lungs and respiratory systems.
- Conditions
- Apnea of Prematurity, Preterm Infant, Periodic Breathing, Hypopnea
- Trial name
- DREAM 2 (NCT07552025)
- Testing
- Wireless acoustic sensor, Semi-structured interview, Nox T3s portable sleep monitoring device
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Child Development
Photo-Plethysmographic Camera to Monitor Heart Rate, Respiration Rate and Oxygen Saturation in Infants
The researchers want to determine if ambient light, plethysmographic , can monitor reliably heart rate, respiration rate and oxygen saturation in infant patients in a hospital setting.
- Trial name
- NCT00989859
- Testing
- Plethysmographic monitoring
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine