Clinical trials: Response Inhibition
Leukoplakia, Periodontal Disease
Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR
In Phase II trials, treatment with ketorolac tromethamine oral rinse has been shown to block periodontal disease progression even in the absence of standard clinical intervention such as scaling and root planing which is…
- Trial name
- NCT00001698
- Testing
- Ketorolac Rinse
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Dyslexia, Executive Dysfunction
The Effects of Play and Competition-Based Cognitive Therapy
Purpose: The aim of this study was to investigate the effects of play and competition-based cognitive therapy (PCB-CT) on executive function and occupational routines in children with dyslexia.
- Trial name
- NCT03906097
- Testing
- Play and Competition-Based Cognitive Therapy
- Volunteers
- 64 people
- Sponsor
- Hacettepe University
Blindness
Brain Plasticity of Verbal Memory in the Blind
This study will examine whether blind people develop changes in the brain that improve memory function. Previous studies have shown that blind people, on average, perform better in memory tasks than sighted people.
- Trial name
- NCT00059189
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervical Pain, Mechanical Neck Pain
Sub-Occipital Muscles Inhibition Technique Verses Cranio Cervical Flexion Exercise for Mechanical Neck Pain
The aim of this research is to determine the Effects of Sub-Occipital Muscles Inhibition Technique and Cranio Cervical Flexion Exercise for Mechanical Neck Pain.
- Trial name
- NCT04545996
- Testing
- Suboccipital Inhibition Technique, Cranio Cervical Flexion Exercises.
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
FSGS, MCD
Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease
Adalimumab, a treatment which blocks tumor necrosis factor (TNF), was tested to see if it changed levels of urine biomarker levels, tissue inhibitor of metalloprotease-1 (TIMP1), and monocyte chemoattractant protein-1 (MCP1).
- Conditions
- FSGS, MCD, Focal Segmental Glomerulosclerosis, Minimal Change Disease
- Trial name
- NCT04009668
- Testing
- adalimumab
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan
ADHD
Assessment of Neurocognitive Rehabilitations of Inhibition of Disorders in ADHD in Children (ERNTITDAH)
This research aims to assess the cognitives rehabilitations in attention deficit disorder (ADHD) in children. the objective is to demonstrate what are the most relevant cognitive factors for rehabilitative to improve the…
- Trial name
- ERNTITDAH (NCT02405299)
- Testing
- experimental groupe
- Where
- France
- Volunteers
- 60 people
- Sponsor
- L'hôpital Nord-Ouest - Villefranche Villefranche sur Saône
Alport Syndrome, Focal Segmental Glomerulosclerosis
Study to Evaluate R3R01 in Patients With Alport Syndrome and Patients With Focal Segmental Glomerulosclerosis
This is a Phase 2, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in Alport Syndrome Patients with Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients with Primary…
- Trial name
- NCT05267262
- Testing
- R3R01
- Where
- 22 sites in United States, Belgium and 4 more
- Volunteers
- 43 people
- Sponsor
- River 3 Renal Corp.
Neuroblastoma (NBL), Ewing Sarcoma
GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors
This study will test a chimeric antigen receptor (CAR) T-cell treatment combined with bevacizumab in children and young adults with relapsed or refractory neuroblastoma, Ewing sarcoma, or osteosarcoma.
- Conditions
- Neuroblastoma (NBL), Ewing Sarcoma, Osteosarcoma
- Trial name
- GD2CART-BEV (NCT07897968)
- Testing
- Chimeric Antigen Receptor (CAR) Therapy Infusion, Bevacizumab (Avastin)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universität Münster
Optical Phenomena
Attention Modulation of Local and Global Inhibition Mechanisms
Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several…
- Trial name
- MILGattention (NCT04279158)
- Testing
- experience 1 "The negative priming task", experience 2 "Stop signal task", experience 3 "Anti-saccades"
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
C3 Glomerulopathy (C3G), Primary Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN), Recurrent Glomerular Disease After Kidney Transplantation
A Study to Assess the Efficacy and Safety of Pegcetacoplan for the Prevention of Recurrent C3G or Primary IC-MPGN in Kidney Transplant Recipients
To assess the efficacy and safety of pegcetacoplan for the prevention of recurrent C3G or primary IC-MPGN in kidney transplant recipients
- Trial name
- PRESERVE (NCT07898774)
- Testing
- Pegcetacoplan
- Where
- 33 sites in Brazil, Canada and 8 more
- Volunteers
- 30 people
- Sponsor
- Swedish Orphan Biovitrum
Depression
REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN the Treatment of DEPRESSION
Subjects received rTMS daily on 10 consecutive weekdays (five sessions per week), during 20 minutes per session.During the rTMS session, the coil was centered flat over the right parietal cortex.
- Trial name
- NCT00220610
- Testing
- Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- St. Lucas Andreas Ziekenhuis Hospital
Acute Coronary Syndrome, Platelet Function
Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis
Introduction: Platelet aggregation plays an important role in ischemic complications in patients undergoing to percutaneous coronary intervention (PCI).
- Trial name
- SAMPA (NCT02215993)
- Testing
- Prasugrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Myopia
Extension Study on Safety and Rebound Effect of SAT-001 for Myopia in Children
The objective of this clinical trial is to collect data on the rebound effect and long-term safety of SAT-001, a Software as a Medical Device (SaMD) under development for the inhibition and treatment of myopia progression in…
- Trial name
- NCT06742268
- Testing
- Single vision spectacles
- Where
- 5 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- S-Alpha Therapeutics, Inc.
Pediatric Obesity, Inhibition
Brain Mechanisms of Overeating in Children
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical…
- Conditions
- Pediatric Obesity, Inhibition, Decision Making, fMRI
- Trial name
- RO1 (NCT03341247)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Penn State University
Kideny Transplant Recipients With High Cardiovascular Risk Score
PCSK 9 Inhibition as Secondary Prevention in Renal Transplant Patients
From this randomized controlled study, we aim to: A.Do do cardiovascular risk stratification of renal transplant recipients who are followed up in Hamed Al-Essa organ transplant center of Kuwait. B.
- Trial name
- NCT04665830
- Testing
- Evolocumab
- Where
- Kuwait
- Volunteers
- 200 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Sarcoma, Sarcoma,Soft Tissue
PARP Inhibition, Stereotactic Body Radiotherapy and Immunotherapy for Metastatic or Advanced Sarcoma (PRIMA)
The aim of this study is to evaluate the efficacy and safety of PARP Inhibition and programmed cell death protein-1 (PD-1) blockade immunotherapy with concurrent stereotactic body radiotherapy (SBRT) for metastatic or advanced…
- Conditions
- Sarcoma, Sarcoma,Soft Tissue, Sarcoma of Bone
- Trial name
- PRIMA (NCT06074692)
- Testing
- Camrelizumab and fluzoparib with concurrent stereotactic body radiotherapy (SBRT)
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Ruijin Hospital
Pulmonary Veno Occlusive Disease
Pilot Study Using Avastin and Gleevec to Treat the Progression of Intraluminal Pulmonary Vein Stenosis
The objective of this study is to conduct a pilot study using biologic agents Avastin and Gleevec to treat progression of multivessel intraluminal pulmonary vein stenosis in children.
- Trial name
- PVS (NCT00891527)
- Testing
- Bevacizumab (Avastin) and Imatinib Mesylate (Gleevec)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Developmental Psychology
The Psychobiology of Childhood Temperament
The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's…
- Trial name
- NCT00060775
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- National Institute of Mental Health (NIMH)
Atopic Dermatitis
A Study of Lebrikizumab in Adults and Adolescents With Face and Neck Atopic Dermatitis
The main aim of the study is to evaluate the efficacy and safety of lebrikizumab treatment for up to 32 weeks in participants with moderate-to-severe face and neck atopic dermatitis (FNAD) who also have moderate-to-severe AD…
- Trial name
- ADface (NCT07873801)
- Testing
- Lebrikizumab
- Volunteers
- 230 people
- Sponsor
- Almirall, S.A.
Movement Disorder, Healthy
Brain Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017966
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)