Clinical trials: Rhinosinusitis
Chronic Rhinosinusitis Without Nasal Polyps
Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps
This is a 12-Week randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy and safety of intranasal administration of 186 µg of OPN-375 twice a day (BID) in adolescent subjects with…
- Trial name
- Re-Open 3 (NCT06850805)
- Testing
- OPN-375
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- Optinose US Inc.
Acute Rhinitis, Nasal Obstruction
Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO"
The purpose of this pre-market clinical investigation is to assess the safety and the performance of decongestant seawater spray pocket valve enriched with essential oils by Gilbert Laboratories.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEVALPO (NCT05494346)
- Testing
- Measurement of peak nasal flow.
- Where
- 5 sites in France
- Volunteers
- 101 people
- Sponsor
- Laboratoires Gilbert
Nasal Obstruction, Common Cold
Observational Study of RHINOSEDAL in Acute Nasal Obstruction
This prospective, multicenter, national, observational, non-interventional post-market clinical follow-up study evaluates the performance and safety of RHINOSEDAL in children and adults presenting with acute nasal obstruction…
- Conditions
- Nasal Obstruction, Common Cold, Allergic Rhinitis, Non-allergic Rhinitis
- Trial name
- RHINOSEDAL (NCT07620522)
- Testing
- RHINOSEDAL
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Laboratoires Elerte
Chronic Sinusitis, Adenoid Disease - Chronic
Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children
The objectives of this study would be to determine the most effective management for pediatric patients with chronic rhinosinusitis and asthma who fail medical management.
- Trial name
- NCT03336671
- Testing
- Endoscopic Sinus surgery, Adenoidectomy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Rhinosinusitis, Asthma
Theophylline in Rhinitis
Allergic rhinitis and asthma are common respiratory diseases, which often coexist. The prevalence of allergic rhinitis in subjects with asthma is up to 80%, and the prevalence of asthma is 3-5 times greater in subjects with…
- Conditions
- Rhinosinusitis, Asthma, Allergic Rhinitis
- Trial name
- NCT01132781
- Testing
- Theophylline (Intervention Group)
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of East Anglia
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital
Covid19
COVID-19 and Acute Invasive Fungal Rhinosinusitis
Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020.
- Trial name
- NCT04809480
- Testing
- Fungal rhinosinusitis
- Volunteers
- 56 people
- Sponsor
- Al-Azhar University
Chronic Sinusitis
Clinical Study to Improve Diagnosis and Treatment of Sinusitis
Chronic rhinosinusitis (CRS) is the most common chronic medical condition that affects Americans between 18-44 years of age. While significant advances have been made in the understanding of the molecular pathogenesis underlying…
- Trial name
- NCT00962689
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University
Acute Rhinosinusitis
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)
This study was conducted to compare the effectiveness and safety of mometasone nasal spray once daily or twice daily with amoxicillin or with placebo in treating the signs and symptoms of acute rhinosinusitis.
- Trial name
- NCT00750750
- Testing
- mometasone furoate nasal spray (MFNS), MFNS, Amoxicillin
- Volunteers
- 981 people
- Sponsor
- Organon and Co
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
China CRSwNP Registry Study
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease of the nose and sinuses that can cause nasal blockage, loss of smell, nasal discharge, facial discomfort, sleep problems, and reduced…
- Trial name
- POLARIS (NCT07795658)
- Testing
- Routine Clinical Care for CRSwNP
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tongren Hospital
Cystic Fibrosis, Sinusitis
Prevalence of Chronic Rhinosinusitis in Cystic Fibrosis
Aim of the study is to detect the prevalence of chronic rhinosinusitis and the colonisation with Pseudomonas aerug. in the upper airways in patients with cystic fibrosis.
- Trial name
- NCT00266474
- Testing
- Assessment of upper and lower airway colonization, sinonasal symptoms, history, rhinoscopy and rhinomanometry.
- Where
- Germany
- Volunteers
- 187 people
- Sponsor
- University of Jena
Chronic Rhinosinusitis, Children
Systemic Methylprednisolone in Chronic Rhinosinusitis
The place of systemic corticosteroids in the treatment of children with chronic rhinosinusitis (CRS) remains unclear. We aimed to assess the effectiveness and tolerability of oral methylprednisolone (MP) as an anti-inflammatory…
- Trial name
- NCT01205984
- Testing
- methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ondokuz Mayıs University
Sinusitis, Acute
Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis
Acute Bacterial Rhinosinusitis (ABRS) is a respiratory inflammation commonly seen in clinical practice, which has with respiratory symptoms including nasal congestion, rhinorrhoea, postnasal discharge and cough and is associated…
- Trial name
- NCT01934231
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- 3 sites in Japan
- Volunteers
- 27 people
- Sponsor
- GlaxoSmithKline
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
- Trial name
- NCT06338995
- Testing
- LY3650150, Standard therapy for INCS
- Where
- 202 sites in United States, Argentina and 18 more
- Volunteers
- 510 people
- Sponsor
- Eli Lilly and Company
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
International Severe CRSwNP Registry 2024-2028
The objective of the study is to collect real-life data worldwide, which already have been collected in national databases, to merge the data and the knowledge with the focus of better care for the individual patients, more…
- Trial name
- INVENT (NCT06617754)
- Testing
- Biologic drugs
- Where
- Denmark
- Volunteers
- 3,000 people
- Sponsor
- Vibeke Backer
Chronic Rhinosinusitis With Polyposis, Chronic Hyperplastic Sinusitis
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization.
- Trial name
- NCT01111669
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Upper Respiratory Tract Infection
A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis
To evaluate the clinical efficacy and safety in patients with Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis receiving a dose of 2 g of azithromycin in the SR formulation.
- Trial name
- NCT00393835
- Testing
- Azithromycin SR
- Where
- 5 sites in Japan
- Volunteers
- 99 people
- Sponsor
- Pfizer
Chronic Rhinosinusitis (CRS), Climate Change Anxiety
Impact of Climate Change Anxiety on Sinusitis Symptoms and Quality of Life Among Adults With Chronic Rhinosinusitis: A Cross-Sectional Study
This cross-sectional observational study investigates the relationship between climate change anxiety and chronic rhinosinusitis (CRS) symptom severity and quality of life (QoL) in adults.
- Conditions
- Chronic Rhinosinusitis (CRS), Climate Change Anxiety, Quality of Life Impairment
- Trial name
- CLIM-RHINO (Cl (NCT07119879)
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Sinai University
Cystic Fibrosis, Rhinosinusitis
Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality of life enormously and give cause to repeated ENT surgery.
- Trial name
- NCT00534079
- Testing
- Dornase alfa (Pulmozyme), isotonic saline
- Where
- 2 sites in Germany
- Volunteers
- 23 people
- Sponsor
- University of Jena