Clinical trials: Rhythm; Sleep
Cataract, Sleep
The Effect of Cataract Surgery on Sleep Quality
A cataract is a clouding of the crystalline lens inside the eye, which leads to a decrease in vision. It is the most prevalent, treatable cause of visual impairment and blindness in the world.
- Trial name
- NCT02593669
- Testing
- Phacomulsification lens removal cataract surgery with neutral Intraocular lens(IOL) implantation, Phacomulsification lens removal cataract surgery with blue-blocking Intraocular lens(IOL) implantation, Subconjunctival dexamethasone and general anesthesia
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Sun Yat-sen University
Mental Disorder in Adolescence, Insomnia
Promoting Sleep and Physical Activity Among Adolescent Psychiatric Patients
Mental health disorders pose a significant burden on adolescent populations globally, often accompanied by sleep disturbances. Emerging evidence suggests that addressing sleep issues can improve mental health outcomes, while…
- Conditions
- Mental Disorder in Adolescence, Insomnia, Delayed Sleep-Wake Phase Disorder
- Trial name
- SLEEPAC (NCT06407258)
- Testing
- SLEEPAC
- Where
- 2 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- Christin Lang
Chromosome Disorders
Melatonin Levels in Smith Magenis Syndrome (SMS)
The goal of this pilot project is to determine whether melatonin levels are disordered in patients with Smith-Magenis Syndrome (SMS) and whether melatonin treatment can correct abnormal circadian rhythms in SMS patients.
- Trial name
- NCT00691574
- Testing
- Melatonin, Enviro-light artificial light box
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Sleep Problem, Neurobehavioral Manifestations
NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood
The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important…
- Trial name
- NapBiome (NCT06396689)
- Testing
- Synbiotic
- Where
- 2 sites in Switzerland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Petra Zimmermann
Smith-Magenis Syndrome, Autism Spectrum Disorder
Smith Magenis Syndrome and Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are a neurodevelopmental disorder. Their prevalence is estimated at around 0.4% of the general population worldwide.
- Trial name
- SMS/TSA (NCT05116904)
- Testing
- Assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Obesity Prevention
The i Heart Rhythm Project: Healthy Sleep and Behavioral Rhythms for Obesity Prevention
This pilot study will examine the feasibility, acceptability, and preliminary efficacy of the intervention. This will ensure that all aspects of the research protocol and procedures work as desired and are acceptable to families…
- Trial name
- NCT04445740
- Testing
- i♥rhythm project
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Developmental Delay Disorders, Chromosome Deletion
Treatment Strategies for Children With Smith-Magenis Syndrome
This study will examine the effect of bright light or melatonin treatment on sleep in children with Smith-Magenis syndrome (SMS), a genetic disorder characterized by certain physical, behavioral and developmental features.
- Conditions
- Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00506259
- Testing
- dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Delayed Sleep-Wake Phase Disorder
Pupillometry in Delayed Sleep Wake Phase Disorder
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder.
- Trial name
- NCT06949644
- Testing
- Light and Citalopram
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Northwestern University
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Circadian Rhythm Disorders, Sleep
The Effects of Bright Light Exposure on ICU Nurses
In the majority of intensive care units, nurses work 12 hour shifts that consist of days and nights. Shift work outside of 6am-6pm has been reported to cause fatigue, induce sleep disorders, and cause metabolic disturbances.
- Trial name
- NCT03331822
- Testing
- Bright Light
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pittsburgh
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Nocturnal Enuresis
The Effect of Melatonin on Nocturnal Enuresis
Aim: To investigate the effect of melatonin in bedwetting.
- Trial name
- NCT01575678
- Testing
- Melatonin, Lactose
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm
Sleep Disorders, Chronotype, and Functional Impairment in the Restrictive ADHD Phenotype
This study aims to explore chronotype and sleep disturbances in ADHD subtypes and their relation to functional impairment.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Sleep Disorders, Circadian Rhythm, Quality of Life, Morningness Eveningness Preference
- Trial name
- NCT06970418
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Cluster Headache
Sleep, Circadian Rhythms and Cluster Headache
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache.
- Trial name
- NCT01447641
- Testing
- Polysomnography, Actigraphy
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Surrey
Bipolar Disorder, Major Depression
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances.
- Conditions
- Bipolar Disorder, Major Depression, Migraine
- Trial name
- NCT05669703
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Preterm Infant, Sleep
Circadian-Synchronized Breast Milk Feeding and Sleep in Preterm Infants: A Multicenter Randomized Controlled Trial
This clinical trial aims to find out whether a circadian-synchronized breast milk feeding approach can help improve sleep in preterm infants in the neonatal intensive care unit (NICU).
- Trial name
- NCT07645677
- Testing
- Circadian-Synchronized Breast Milk Feeding, Routine Breast Milk Feeding
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Sleep, Circadian Rhythm
HEARTBEAT SOUND FOR BREASTFEEDİNG DİFFİCULTİES: A RANDOMİZED CONTROLLED TRİAL
This randomized controlled trial aims to evaluate the effect of listening to a pre-recorded, standardized maternal heartbeat sound on perceived stress levels and breastfeeding self-efficacy in mothers experiencing early…
- Conditions
- Sleep, Circadian Rhythm, Pregnancy, Newborn
- Trial name
- NCT07881484
- Testing
- Standardized Maternal Heartbeat Sound Application
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hakan Avan
Delayed Sleep Phase Syndrome
Does Cognitive Behaviour Therapy (CBT) Improve the Effect of Light Therapy
Delayed sleep phase syndrome (DSPS) is the most common of the circadian rhythm sleep disorders (CRSD). A person with DSPS have sufficient sleep quality, but their circadian clock is delayed compared to the normal 24-h period.
- Trial name
- NCT01419938
- Testing
- Light therapy and Cognitive behaviour therapy, Light therapy
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Uppsala University
Narcolepsy, Obstructive Sleep Apnea
The Nuvigil and Provigil Pregnancy Registry
The primary objective of the Nuvigil/Provigil Pregnancy Registry is to characterize the pregnancy and fetal outcomes associated with Nuvigil and Provigil exposure during pregnancy.
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Shift Work Sleep Disorder
- Trial name
- NCT01792583
- Testing
- Modafinil/armodafinil
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Cephalon, Inc.