Clinical trials: Rhythm; Sleep
Obstructive Sleep Apnea, Heart Rhythm Disorder
Obstructive Sleep Apnea Destabilizes Myocardial Repolarization Homogeneity
Literature shows that patients with obesity and Obstructive Sleep Apnea (OSA), both occurring independently, are more likely to develop cardiovascular diseases and sudden cardiac death (SCD).
- Conditions
- Obstructive Sleep Apnea, Heart Rhythm Disorder, Obesity, Abdominal
- Trial name
- NCT04621032
- Testing
- Polygraphy monitoring, laboratory tests
- Volunteers
- 187 people
- Sponsor
- Nowodworskie Centrum Medyczne
Sleep Deprivation, Circadian Rhythm Disorders
PBM Effects on Health and Well-being in Humans
The goal of this clinical study is to assess the effects of different photobiomodulation (PBM) conditions in men and women between 25 and 65 years old with daytime sleepiness/drowsiness and /or mild mood complaints but be…
- Trial name
- NCT05619133
- Testing
- PBM
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seaborough Life Science B.V.
Sleep Circadian Rhythms, Chronodisruption
Assessing Sleep and Circadian Rhythms in Primary Brain Tumors Patients
Background: Sleep disturbances are among the most common and severe symptoms reported by people with primary brain tumors (PBT).
- Trial name
- NCT04669574
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- National Cancer Institute (NCI)
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity, Blood Pressure
- Trial name
- SHINE (NCT06550115)
- Testing
- Time-restricted eating, Control eating
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Sleep Disorders
Sleep Length and Circadian Regulation in Humans
This research will examine why sleep restriction reduces the body clock's response to bright light. The results will enable the optimization of the bright light treatment of people who suffer from circadian rhythm sleep…
- Trial name
- HAM (NCT00843843)
- Testing
- Bright light box
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain…
- Trial name
- NCT01742182
- Testing
- Light exposure
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Restless Legs Syndrome (RLS)
Effectiveness of Matrix Rhythm Therapy for Restless Legs Syndrome
The goal of this clinical trial is to evaluate whether Matrix Rhythm Therapy (MRT), when added to a home exercise program, is effective in reducing symptoms of Restless Legs Syndrome (RLS) in adult women.
- Trial name
- MRT-RLS (NCT07561476)
- Testing
- MATRİX RHYTHM THERAPY, HOME EXERCISE PROGRAM
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Pamukkale University
Blindness
Blind Child Melatonin Treatment Study
The primary focus of this five-year study will be to optimize the melatonin dosing regimen for synchronizing the body clocks of blind children to the 24-hour day.
- Trial name
- NCT00691444
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Non-visual Photoreception
Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep
The timing and quality of sleep is governed by environmental and physiologic factors. Environmental factors, especially ambient lighting can impact the circadian system and alter the timing and structure of sleep.
- Trial name
- NCT01586039
- Testing
- Visible light
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Circadian Rhythm Sleep Disorder
Circadian Rhythms and Sleep in Familial DSPS and ASPS
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
- Trial name
- NCT00246454
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Northwestern University
Delayed Sleep-Wake Phase Disorder
Pupillometry in Delayed Sleep Wake Phase Disorder
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder.
- Trial name
- NCT06949644
- Testing
- Light and Citalopram
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Northwestern University
Parkinson's Disease
Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease
Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain…
- Trial name
- NCT02909192
- Testing
- Light Therapy Device
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Stroke, Sleep
Personalised Sleep and Circadian Intervention After Stroke
This is a two-arm, parallel-group randomized controlled feasibility trial involving 40 community-dwelling adults with chronic stroke and ongoing sleep or circadian difficulties.
- Trial name
- NCT07731516
- Testing
- ISleepFAST, Stroke and Sleep Health Education
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Elderly Housing Residents With Frailty or Dementia
Circadian Adjusted LED Light's Effect in People Living in Elderly Housing
Europe is undergoing a demographic change with a rapidly growing population of 65 years+. This challenges municipalities and hospitals as the ageing citizens need care and treatment due to an age-related decline in physical and…
- Trial name
- Lightel (NCT03263234)
- Testing
- 8 weeks of circadian adjusted LED-based lighting (CALED)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Ove Andersen
Diabetic Retinopathy, Melatonin
Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm
This study evaluates the effect of melatonin 4 mg on circadian rhythm and visual function of patients with diabetes mellitus. Half of the patients will receive melatonin (arm-1) and the other half will receive placebo (arm-2)…
- Conditions
- Diabetic Retinopathy, Melatonin, Circadian Dysrhythmia, Circadian Rhythm Sleep Disorder, Unspecified Type
- Trial name
- NCT03478306
- Testing
- Melatonin 4 mg Tablet
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Breast Neoplasms
Exploring Biological Linkage Between Circadian Disruption and Cancer Progression
The purpose of this study is to explore the possible association between the circadian disruption and cancer progression.
- Trial name
- NCT02011815
- Where
- South Korea
- Volunteers
- 236 people
- Sponsor
- Seoul National University Hospital
Healthy Aging
Vestibular Stimulation, Exercise and Light Optimization for Circadian Clock Enhancement (Velocce)
This study investigates the effects of remote interventions based on the exposure to one or more zeitgebers (i.e. adapted physical activity alone or combined with bright light exposure, or galvanic vestibular stimulation)…
- Trial name
- velocce (NCT05030389)
- Testing
- Adapted Physical Activity (APA), Bright Light Exposure (BLE), Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Aging, Sleep Deprivation
Effects of Chronic Sleep Restriction in Young and Older People
The purpose of this study is to examine the consequences of chronic sleep restriction on nighttime sleep, daytime alertness, performance and memory functions, and metabolic and cardiovascular function, and to determine if the…
- Conditions
- Aging, Sleep Deprivation, Metabolic Syndrome
- Trial name
- NCT00506428
- Testing
- chronic sleep restriction
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Psychosis, Sleep
Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms
Randomized control trial assessing supplemental melatonin for youth with at-risk or psychotic symptoms.
- Trial name
- NCT03826563
- Testing
- oral melatonin tablets (NatureMade brand)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital of Philadelphia