Clinical trials: Rigidity
MDC1A, SELENON-related Myopathy
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2
SEPN1 (SELENON) is a rare congenital myopathy due to mutations in the SELENON gene. MDC1A is a rare congenital muscle dystrophy due to mutations in the LAMA2 gene.
- Trial name
- NCT04478981
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Radboud University Medical Center
Fractures, Bone, Impending Fracture
Retrospective Study on Clinical Performance and Safety Profile of Agile Nail
This study aims to retrospectively collect data from routine clinical practice in order to evaluate the safety profile of the Agile intramedullary nail, used in pediatric patients according to the manufacturer Instructions For…
- Conditions
- Fractures, Bone, Impending Fracture, Deformity; Bone
- Trial name
- Agile (NCT06412939)
- Testing
- Agile Nail
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Orthofix s.r.l.
Respiratory Distress Syndrome in Preterm Infants
LISA Rigid Catheter vs LISA Soft Catheter in a Very Preterm Manikin
Less invasive surfactant administration (LISA) can be provided using rigid or soft catheters, but possible differences in terms of easiness of use and success of the procedure are unknown.
- Trial name
- NCT05388175
- Testing
- Rigid catheter, Soft catheter
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Myopia
Post-market Follow Up Study on Paragon CRT® 100 (Paflufocon D)
The main objective of this post market clinical study is to evaluate the effectiveness and safety of the Paragon CRT®100 Contact Lens.
- Trial name
- NCT04187599
- Testing
- Paragon CRT®100 Contact Lens
- Where
- 4 sites in China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)
Movement Disorder
Human Movement Database
This study will collect information on the different ways people control limb and body movements. This information will be used to develop a database on normal movements and adaptive movements of people who have diseases that…
- Trial name
- NCT00001252
- Where
- United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Ocular Surface Disease, Irregular Astigmatism
Evaluation of the Safety and Efficacy of Rigid Breathable Scleral Contact Lenses for the Correction of Ametropia
To evaluate the short-term efficacy and safety of scleral contact lens in the clinical treatment of patients with irregular astigmatism after corneal transplantation by analyzing ocular parameters and ocular surface conditions of…
- Conditions
- Ocular Surface Disease, Irregular Astigmatism, Contact Lens Complication, Corneal Astigmatism
- Trial name
- NCT06256770
- Where
- China
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Sickle Cell Disease, Renal Disease
Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients
- Conditions
- Sickle Cell Disease, Renal Disease, Glomerular Disease
- Trial name
- NCT04380610
- Testing
- iohexol GFR
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chest Wall Tumor
Innovative Approaches to Chest Wall Reconstruction: A Comparative Study of Rigid and Flexible Techniques
Chest wall resections, often performed for tumors, infections, or trauma, result in significant defects that require reconstruction to restore structural integrity and functionality.
- Trial name
- NCT07167810
- Testing
- bone cement, steel wires
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- University of Health Sciences Lahore
Gastric Bypass
Prospective Trial Using Gastric Stapling Line Reinforcement With Seamguard in Roux-en-Y Gastric Bypass
Study objectives : Primary endpoint is to a assess the change in blood loss (originating from stapling the stomach) with the use of Seamguard reinforcement Secondary endpoint is to evaluate the difference in leak rate Methods …
- Trial name
- NCT01015157
- Testing
- Roux-en-Y laparoscopic gastric bypass for morbid obesity
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Clinique de l'Anjou
Foreign Body Aspiration
Routine Chest X-ray Post Rigid Bronchoscopy for Foreign Body Extraction: is it Necessary?
Airway foreign body is one of the common emergencies. Its clinical presentation is variable, ranging from a clinically asymptomatic state to dire state of respiratory failure needing urgent attention and intervention.
- Trial name
- NCT06106503
- Testing
- chest x-ray, clinical examination
- Volunteers
- 100 people
- Sponsor
- Assiut University
Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)
Congenital Muscle Disease Study of Patient and Family Reported Medical Information
The Congenital Muscle Disease Patient and Proxy Reported Outcome Study (CMDPROS) is a longitudinal 10 year study to identify and trend care parameters, adverse events in the congenital muscle diseases using the Congenital Muscle…
- Conditions
- Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)
- Trial name
- CMDPROS (NCT01403402)
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Cure CMD
Arthritis, Juvenile Rheumatoid
Foot Orthoses (FOs) on Pain, Quality of Life and the Gait With Children Diagnosed With JIA
Modern modular foot-orthoses systems allow an integration of the cost and efficiency benefits afforded by the use of pre-formed semi-rigid FOs components, while simultaneously allowing a high degree of individualisation of…
- Trial name
- NCT02001844
- Testing
- Trial Foot Orthoses (FOs)
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- University of Newcastle, Australia
Chronic Kidney Disease Requiring Chronic Dialysis, Cardiovascular Calcification
The Intravenous Amino Acid Therapy for Vascular Rigidity in End Stage Renal Disease
The goal of this study is to learn if giving amino acids through the dialysis machine can help protect the blood vessels and heart in people with kidney failure.
- Trial name
- NASCAR (NCT07392697)
- Testing
- Amino Acid Supplementation, Sterile Saline Arm
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Haukeland University Hospital
Cervical Myelopathy
Are Rigid Cervical Collars Necessary for Open-door Laminoplasty and Titanium Arch Plates for Cervical Myelopathy?
This is a randomized controlled trial to assess the use of rigid neck collar postoperatively. It consists of patients with cervical myelopathy undergoing open-door laminoplasty with titanium arch plates.
- Trial name
- NCT03400644
- Testing
- Cervical collar
- Where
- Hong Kong
- Volunteers
- 35 people
- Sponsor
- The University of Hong Kong
Myopia
Evaluating the Efficacy and Safety of Contact Lens Lubricant in Rigid Gas Permeable Corneal Contact Lens Wearers
This trial aims to evaluate the safety and effectiveness of LACRIFRESH OCU-DRY 0.3% OSD, a contact lens lubricant produced by AVIZOR, S.A.
- Trial name
- NCT07091825
- Testing
- LACRIFRESH OCU-DRY 0.3% OSD, Rigid contact lens lubricant
- Where
- 3 sites in China
- Volunteers
- 152 people
- Sponsor
- Avizor SA
Pleurisy With Effusion
A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions
Rigid thoracoscopy is an established procedure for the performance of pleural biopsies for undiagnosed pleural effusions. The semirigid thoracoscope is a relatively new instrument designed for the same purpose which is claimed to…
- Trial name
- RISE (NCT01726556)
- Testing
- Rigid thoracoscope (Richard Wolf GmbH, Knittlingen, Germany), Semirigid thoracoscope (model LTF-160Y1, Olympus, Japan)
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Post-Surgical Contamination of Rigid Endoscopic Instruments
Cleaning Efficacy of Pulsed Vacuum Device on Rigid Endoscopic Instruments
This study is a prospective, comparative trial designed to evaluate the cleaning effectiveness of a novel pulsed vacuum cleaning and disinfection device against a conventional vacuum ultrasonic cleaner for rigid endoscopic…
- Trial name
- NCT07077499
- Testing
- Pulsed Vacuum Cleaning and Disinfection Device, Vacuum Ultrasonic Cleaner
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Xue Wang
Retrograde Intrarenal Surgery In Management Of Renal Stones
to Study the Role of Retrograde Intrarenal Surgery in Management of Renal Stones
Role Of Retrograde Intrarenal Surgery In Management Of Renal Stones: Single Center Experience
- Trial name
- NCT05648877
- Testing
- Ureteroscope
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Menoufia University
Bladder Cancer
A Novel Application of 2% Lidocaine Injection for Male Rigid cycstoscopy-a Patient-blinded Randomised Trial
The goal of this clinical trial is to learn about a novel application of lidocaine injection in male patients who needs rigid cycstoscopy test.
- Trial name
- NCT06301308
- Testing
- Intraurethral lidocaine gel alone, Intraurethral lidocaine gel + lidocaine 2% injection, intraurethral lidocaine gel + liquid paraffinl
- Where
- China
- Sponsor
- Second Xiangya Hospital of Central South University