Clinical trials: Self-Injurious Behavior
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Suicide
Suicide Prevention for Sexual and Gender Minority Youth (Case Series)
The overarching goal of this study is to develop a suicide prevention program for sexual-and-gender-minority youth and emerging adults.
- Trial name
- NCT04757649
- Testing
- Safety Planning Intervention with Navigation Services
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Suicide Prevention
Brief Suicide Intervention for Youth in Juvenile Detention Settings
This is an intervention development study and therefore is not designed or powered to test hypotheses. Following initial development and refinement of intervention and protocol, an open trial will be conducted at one juvenile…
- Trial name
- NCT05225103
- Testing
- SAFETY-Acute intervention
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Duke University
Insomnia
Effectiveness of eCBT-I on Improving Mental Health in Chinese Youths With Insomnia
This study aims to conduct a randomized control trial to validate the treatment effect of e-based cognitive behavioral therapy for Insomnia (e-CBT-I) on insomnia disorder, and explore whether e-CBT-I could prevent depression and…
- Trial name
- NCT04069247
- Testing
- e-CBT-I, e-HE
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 708 people
- Sponsor
- Chinese University of Hong Kong
Depression, Suicidal Ideation
Screening Wizard- Phase 2
Screening Wizard (SW). Primary Care Providers (PCPs) are often uncertain about how to best refer adolescents who screen positive for depression or suicidality.
- Trial name
- NCT04646369
- Testing
- "screening as usual", Screening Wizard 2.0, Screening Wizard 2.0 + SOVA
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Suicide
Promoting Community Conversations About Research to End Native Youth Suicide in Rural Alaska
This intervention study measures the outcomes of the PC CARES (Promoting Community Conversations about Research to End Suicide) project implemented in remote rural Alaskan villages.
- Trial name
- PC CARES (NCT03661255)
- Testing
- PC CARES
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Suicide Prevention
Feasibility Trial of a Single Session of Crisis Response Planning for Youth at High Risk for Suicide
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health-related behavioral outcomes.
- Trial name
- NCT06164106
- Testing
- Virtual Crisis Response Planning, In-Person Crisis Response Planning, Crisis Risk Counseling
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Ohio State University
Autism Spectrum Disorder
A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder
The purpose of this study is to demonstrate the feasibility of a 9-week, randomized trial of N-acetylcysteine (NAC) compared to placebo in 14 children (age 5 to 12 years) with Autism Spectrum Disorder (ASD) and a moderate level…
- Trial name
- NAC (NCT03008889)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University
Self-Injurious Behavior, Deliberate Self-Harm
A Study Examining Adolescents With Non-Suicidal Self-Injury
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI).
- Trial name
- RDoC (NCT02947308)
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Substance Misuse, Suicide
A Digital Game Targeting Suicide Prevention in Adolescents Who Report Substance Misuse
The primary aim of this study is to design and develop a digital game that models the process of a safety planning intervention.
- Trial name
- NCT05517382
- Testing
- supportED, Control
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression
iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
This is an open label, pilot, feasibility study evaluating effects of Intermittent Theta Burst Transcranial Magnetic Stimulation (iTBS) on 5 eligible adolescents for the treatment of depression.
- Trial name
- NCT04485455
- Testing
- iTBS Device/Motor Threshold Coil, iTBS Device/Treatment Coil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Rumination, Depression
Adolescent Mindfulness Mobile App Study (RCT)
Rumination involves focusing on negative emotions repeatedly and is a risk factor for developing depression, anxiety, and self-injury. These negative outcomes increase in adolescence.
- Conditions
- Rumination, Depression, Anxiety, Self-Injurious Behavior
- Trial name
- AMMASRCT (NCT03900416)
- Testing
- Mindfulness App
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Suicide, Depression
Attachment Based Family Therapy for Suicidal Adolescents
This study will evaluate the efficacy of attachment based family therapy (ABFT) for treatment of suicidality in adolescents. The study will compare 16 weeks of treatment with ABFT to a control condition Family Enhanced…
- Conditions
- Suicide, Depression, Family Relationships
- Trial name
- NCT01537419
- Testing
- Attachment-Based Family Therapy, Family-Enhanced Non-directive Supportive Therapy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Drexel University
Suicidal Ideation
The Elders' Resilience Curriculum
The overall goal of this research is to better understand if and how the Elders' Resilience Curriculum (ERC), a culturally grounded, school-based upstream suicide prevention program taught by White Mountain Apache Tribe (WMAT)…
- Trial name
- NCT06045273
- Testing
- Elders' Resilience Curriculum
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Suicide
Adaptive Implementation Intervention for VA Suicide Risk Identification Strategy
The overall objective of this national quality improvement project is to develop an adaptive implementation strategy to improve the implementation of suicide risk screening and evaluation in Veterans Health Administration…
- Trial name
- NCT04243330
- Testing
- Audit and Feedback, External Facilitation
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Suicide, Self Harm
An Adaptive Intervention for Adolescents at Risk for Suicide: A Pilot SMART
To inform the development of a technology-augmented adaptive intervention for adolescents at risk for suicide, the goal of this study is to conduct a Sequential, Multiple Assignment, Randomized Trial (SMART) pilot of a…
- Trial name
- NCT03838198
- Testing
- MI-Enhanced Safety Plan at Hospitalization (1st Component), MI-Enhanced Text Boosters (2nd Component), MI-Enhanced Booster Call (3rd Component)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan
Suicidal Ideation
Observational Study to Compare Outcomes of Different Psychiatric Treatment of Suicidal Adolescents
To address the unmet need of optimizing the treatment and management for adolescent suicidality, the investigators propose to evaluate the effectiveness and safety of telehealth services compared to inpatient and OCIC for…
- Trial name
- Pre-START (NCT04625686)
- Testing
- Mental Health Treatment
- Where
- 4 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Suicide
REACH VET Implementation Program Evaluation
The VA's Office of Mental Health and Suicide Prevention implemented an new program to increase suicide prevention outreach for Veterans at highest risk for suicide.
- Trial name
- REACH VET (NCT03280225)
- Testing
- External facilitation
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development