Clinical trials: Sense of Control
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Amblyopia, Visual Training
A Randomized Controlled Trial of Autostereoscopic 3D Vision Therapy for Amblyopia
The goal of this clinical trial is to learn if an autostereoscopic 3D amblyopia training system works to improve vision in children and adolescents with amblyopia.
- Conditions
- Amblyopia, Visual Training, Visual Functions, Visual Health
- Trial name
- NCT07709832
- Testing
- Autostereoscopic 3D Training, Conventional Patching
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Beijing Tongren Hospital
S-ketamine, Esketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Children
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in children in perioperative settings.
- Conditions
- S-ketamine, Esketamine, Acute Pain, Postoperative Pain
- Trial name
- NCT04834427
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Effectiveness of Application Education Intervention, Noise Induced Hearing Loss
Prevention of Noise-Induced Hearing Loss in Primary Education
The goal of this randomized controlled trial is to evaluate the effectiveness of the educational program the HoorToren in promoting recreational safe listening behavior among Dutch primary school children in group 7 (aged 10-11…
- Conditions
- Effectiveness of Application Education Intervention, Noise Induced Hearing Loss, Behavior Change Interventions, Primary School Children
- Trial name
- NCT07513077
- Testing
- HoorToren educational package
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Sensory Integration Disorder
Sensory Integration for Infants With Cortical Visual Impairment
Our study examines the effect of sensory integration training on sensory, motor and oculomotor skills in infants with cortical vision impairment .
- Trial name
- NCT05431647
- Testing
- Sensory integration therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Retinitis Pigmentosa (RP), Usher Syndrome Type 2
Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene
The purpose of this Phase 2b study is to evaluate the safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene.
- Conditions
- Retinitis Pigmentosa (RP), Usher Syndrome Type 2, Deaf Blind, Retinal Disease
- Trial name
- LUNA (NCT06627179)
- Testing
- Intravitreal Injection of Ultevursen, No intervention, will not receive any active study intervention
- Where
- 26 sites in United States, Belgium and 8 more
- Volunteers
- 81 people
- Sponsor
- Laboratoires Thea
Balance Control
Impact of Physical Activities on Balance in Patient With Strabismic Amblyopia
The aim of this study is to determine the effect of physical activities on balance in patient with amblyopia after strabismus surgery.
- Trial name
- NCT06758063
- Testing
- exercises therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Amany Refaat Mohamed Abdel Wahid
Primary Dystonia, Epilepsy
Assess Specific Kinds of Children Challenges for Neurologic Devices Study
The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the…
- Conditions
- Primary Dystonia, Epilepsy, Hydrocephalus, Bladder Control
- Trial name
- NCT01191307
- Volunteers
- 16 people
- Sponsor
- Carlos Pena, PhD, MS
Breast Neoplasms
Impact of Robotic Versus Endoscopic Surgery on Nipple Nerve Function Following Nipple-Sparing Mastectomy for Breast Cancer
This is a multicenter, prospective, randomized parallel controlled two arm clinical trial, designed to systematically evaluate impact of robotic versus endoscopic surgery on breast nerve function in patients undergoing nipple…
- Trial name
- NCT07850154
- Testing
- Robotic-assisted nipple-sparing mastectomy, Endoscopic-assisted nipple-sparing mastectomy
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Stroke, Caregiver Social Support
Optimizing Stroke Family Caregiver Support Across the Care Continuum by Improving the Timing of Intervention Delivery
About 50% of stroke survivors have limitations in their activities of daily living on return to the community. Family caregivers provide invaluable support to these individuals during their recovery and rehabilitation.
- Conditions
- Stroke, Caregiver Social Support, Caregiver Mental Health, Caregiver Sense of Control Over Life
- Trial name
- NCT00958607
- Testing
- Timing it Right Stroke Family Support Person Intervention, Self-directed program
- Where
- Canada
- Volunteers
- 310 people
- Sponsor
- University of Toronto
Dental Anxiety of Hearing Impairment
Effectiveness of Virtual Reality vs Show-Do Technique on Dental Anxiety in Children With Hearing Impairment
This randomized controlled clinical trial aims to compare the effectiveness of virtual reality (VR) eyewear used as a distraction method in combination with the Show-Do (SD) technique versus the traditional Show-Do technique…
- Trial name
- NCT07245030
- Testing
- virtual reality distraction, show-do technique
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- October University for Modern Sciences and Arts
Leber Congenital Amaurosis 10, Blindness
An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene.
PQ-110-005 (BRIGHTEN) is an open-label, dose escalation and double-masked, randomized, controlled study evaluating safety and tolerability of sepofarsen administered via intravitreal (IVT) injection in pediatric subjects (<8…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders
- Trial name
- BRIGHTEN (NCT04855045)
- Testing
- sepofarsen
- Where
- 9 sites in Belgium, Brazil and 5 more
- Volunteers
- 15 people
- Sponsor
- ProQR Therapeutics
Dental Anxiety, Dental Pain and Sensation Disorder
The Effectiveness of Audiovisual Distraction Behavior Guidance Technique in Children With Dental Anxiety
This randomized, two-armed, placebo-controlled, cross-over, controlled trial aimed to evaluate the effect of virtual reality exposure therapy (VRET) on dental anxiety, pain, and behaviour among children undergoing dental…
- Trial name
- NCT04226651
- Testing
- Virtual Reality Device, Protective glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Achromatopsia
Safety and Efficacy of rAAV.hCNGA3 Gene Therapy in Patients With CNGA3-linked Achromatopsia
The purpose of this study is to proof the safety and efficacy of a single bilateral subretinal injection of rAAV.hCNGA3 in adult and minor patients with CNGA3-linked achromatopsia.
- Trial name
- Colourbridge (NCT02610582)
- Testing
- rAAV.hCNGA3
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- STZ eyetrial
Suicide Attempt
Treating Suicidality Remotely
Background: Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to get professional help.
- Trial name
- TREASURE (NCT06370104)
- Testing
- Brief Cognitive Behavioral Therapy for Suicide Prevention, Living under control
- Where
- Netherlands
- Volunteers
- 364 people
- Sponsor
- 113 Suicide Prevention
Technology
Effectiveness of a Smart Hearing Aid on Improving Psychosocial Well-being in Elderly
The study has 2 primary research questions, 4 secondary research questions, and 2 auxiliary research questions targeting elderly with hearing impairment. The research questions are: Primary study questions: 1.
- Trial name
- NCT05772949
- Testing
- Experimental group intervention, Wait-list control group intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 33 people
- Sponsor
- The University of Hong Kong
Visual Impairment, Cerebral Visual Impairment
VIPPSTAR-G1 Digital Early Intervention for Visual Impairment
Visual impairment in infancy is associated with significant risks for neurodevelopmental impairment. Early intervention based on enriched visual and multisensory experiences may promote neuroplasticity and improve developmental…
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Neurodevelopmental Disorders, Prematurity
- Trial name
- VIPPSTAR-G1 (NCT07717671)
- Testing
- VIPPSTAR Digital Early Intervention, Standard Clinical Care
- Where
- 5 sites in Belgium, Italy and 1 more
- Volunteers
- 150 people
- Sponsor
- Università degli Studi di Brescia
Fear Pain
Human Behaviors Related to the Expectation of Pain
The conditioned expectation of pain is an important aspect of pain-related disability produced by environments and stimuli associated with a painful injury on the job, although the neuroscience of this expectation is unclear.
- Trial name
- NCT03739645
- Testing
- Skin conductance levels and slopes over time in conditioned fear as metrics.as metrics for anxiety
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- NCT05096273
- Testing
- ReACT
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hearing Loss
The Hearing Aid Effectiveness After Aural Rehabilitation (HEAR) Trial
This study compares the effectiveness of hearing aid appointments provided in a group format to those provided in an individual format.
- Trial name
- NCT00260663
- Testing
- Group hearing aid fittings, Group hearing aid follow-up
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- US Department of Veterans Affairs