Clinical trials: Sensitisation
Allergic Reaction
Epidemiology of Pecan Nut Allergy
IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of…
- Trial name
- PEC-ALL (NCT05185362)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Food Allergies
Endophenotyping for Plant-based Food Allergy Diagnosis, Tolerance Biomarkers, and Mechanisms in Microneedle Immunotherapy
In relation to the prognosis of vegetable FA (VFA), in contrast to other food allergies (FA), which disappear naturally with time, VFA tends to persist into adulthood and to the appearance of new sensitizations to other…
- Trial name
- NCT06997432
- Testing
- Dietary intervention
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Osteoarthritis of Knee, Central Sensitization
Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty
Analgesic effect of 20mg Duloxetine was evaluated at regular short term intervals in patients without central sensitivity and undergoing bilateral single sitting total knee arthroplasty for tricompartmental osteoarthritis using…
- Conditions
- Osteoarthritis of Knee, Central Sensitization, Central Sensitisation
- Trial name
- NCT06837012
- Testing
- Duloxetine - low dose
- Where
- India
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Arthroscopy Knee and Shoulder Clinic
Allergy to Fenugreek
Relevance of Sensitization to Fenugreek in Children
The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen.
- Trial name
- NCT05340920
- Testing
- Oral Food Challenge
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Food Allergy in Children
Lupine Allergy in Children
All children sensitized to lupine who have performed an oral food challenge (OFC) to lupine between January 2017 and May 2024 in the Pediatric Allergy Unit of the University Hospital of Nancy were included.
- Trial name
- NCT06918249
- Testing
- No intervention
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Osteoarthritis
Neuroscience Education on Osteoarthritis
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain.
- Trial name
- NCT02246088
- Testing
- MT + NE, MT + E
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- University of Valencia
Food Allergy, Food Allergy in Infants
The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy
The BAT Impact study is a prospective multicentre study in the UK using a biomarker-led study design to compare the incidence of adverse events (defined as allergic reactions during oral food challenges) in a…
- Conditions
- Food Allergy, Food Allergy in Infants, Food Allergy in Children, Food Allergen Sensitisation
- Trial name
- NCT05309772
- Testing
- Basophil activation test (BAT), Oral food challenge (OFC)
- Where
- 11 sites in United Kingdom
- Volunteers
- 398 people
- Sponsor
- King's College London
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Kidney Transplantation, Immunosuppressive Agents
Anti-HLA Immunization And Immunosuppressive Therapy Management In Kidney Transplant Patients Returning to Dialysis
This study is an analytical observational retrospective cohort study. It is a single-center study conducted in the Nancy University Hospital. End stage renal disease is the ultimate stage of the chronic kidney disease.
- Conditions
- Kidney Transplantation, Immunosuppressive Agents, HLA Sensitization, Dialysis
- Trial name
- NCT05282875
- Testing
- management of immunosuppressive therapy
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Central Hospital, Nancy, France
Atopy, Allergy
Biodiversity Intervention and Atopic Sensitization
Children will receive biodiversity intervention or placebo. The proof of concept trial is double blind. Intervention will start at the age of 2 months and last 10 months. Children will be randomized to arms.
- Conditions
- Atopy, Allergy, Allergic Rhinitis, Allergic Sensitisation
- Trial name
- PREVALL (NCT03872219)
- Testing
- Nature-based materials
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Food Allergy in Children, Obesity, Childhood
The EAT-On Study: Sensitisation, Allergy and Child Health
The EAT Study showed a reduction in both sensitisation (to all foods) and clinical food allergy (to peanut and egg) among children who consumed allergenic food early compared with those who followed standard government feeding…
- Conditions
- Food Allergy in Children, Obesity, Childhood, Food Allergen Sensitisation
- Trial name
- NCT03495583
- Testing
- Early introduction
- Where
- United Kingdom
- Volunteers
- 1,235 people
- Sponsor
- King's College London
Allergy to Peanut
Predictors of Persistent Peanut Allergy at Age 5 Years
The purpose of this study is to determine if avoidance of peanut by children with positive allergy testing to peanut in the first 5 years of life increases the likelihood of developing a persistent peanut allergy by age 5 years.
- Trial name
- NCT02497261
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Abdominal Pain, Irritable Bowel Syndrome
Pain Processing and Pain Neuroscience Education in Children With Chronic Abdominal Pain
The primary scientific objective of the study entails examining whether altered endogenous pain inhibition is present in children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS) compared with healthy…
- Trial name
- NCT02880332
- Testing
- Usual care, Pain Neuroscience education, Extra care
- Where
- Belgium
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Necrotizing Enterocolitis, Allergy
Investigation of Allergen Sensitization in Newborn Babies Diagnosed With Necrotizing Enterocolitis.
To evaluate the frequency of allergy between 12 and 24 months of age in infants who were treated in the neonatal clinic and had NEC.
- Conditions
- Necrotizing Enterocolitis, Allergy, Preterm
- Trial name
- AlisNEC (NCT07562009)
- Testing
- skin prick test
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Asthma
Mold Sensitization Associated Severe Asthma Exacerbation
Mold sensitization is associated with severe asthma exacerbation.
- Trial name
- NCT03690349
- Testing
- Skin test
- Volunteers
- 102 people
- Sponsor
- Mahidol University
Chronic Pain
The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity
The goal of this clinical trial is to learn if pain knowledge group intervention among chronic pain patients would influence their level of physical activity, pain intensity, depression, kinesiophobia and central sensitization.
- Trial name
- NCT07491549
- Testing
- pain education
- Where
- Estonia
- Volunteers
- 50 people
- Sponsor
- University of Tartu
Allergic Disorder, Food Hypersensitivity
Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age…
- Conditions
- Allergic Disorder, Food Hypersensitivity, Food Allergy in Children
- Trial name
- NCT05442658
- Testing
- Microbiota
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Food Allergy
Analysis of the Prevalence of Sensitization to Plants Containing Gibberellins Using Realistic Skin Prick Tests
Gibberellin-related proteins (GRPs) are proteins contained in both pollens and vegetables and are associated with an increased risk of severe food allergy reactions.
- Trial name
- GIBBERELLINES (NCT06183398)
- Testing
- Skin prick test
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier