Clinical trials: Sensitisation
Hand Exercises for Rheumatoid Arthritis
Is a Standard Hand Rehabilitation Program Sufficient in Rheumatoid Arthritis Patients With Central Sensitization
The presence of central sensitization leads to overestimation of pain sensitivity and disease activity in rheumatoid arthritis (RA) patients.
- Trial name
- NCT07598240
- Testing
- Exercise1, Exercise2, Exercise3
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Fulya Coşkun
Asthma
Mold Sensitization Associated Severe Asthma Exacerbation
Mold sensitization is associated with severe asthma exacerbation.
- Trial name
- NCT03690349
- Testing
- Skin test
- Volunteers
- 102 people
- Sponsor
- Mahidol University
Obesity, Adolescent, Adolescent Behavior
Study of Nutrition and Activity in Kids
While a substantial body of research suggests that RRV is related to obesity, there is very little research on factors that contribute to the RRV of food, particularly how patterns of eating can increase or decrease the…
- Trial name
- SNAK (NCT04027608)
- Testing
- Reinforcing value of HED and LED foods in response to snack food monotony
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Chemo Sensitization Before Hematopoietic Stem Cell Transplantation in Patients With Acute Leukemia in Complete Remission
The purpose of this study is to evaluate the disease free survival and the overall survival in patients with acute leukemia in first or second complete remission after administrating a CXCR4 antagonist, as a chemo sensitization…
- Trial name
- NCT02605460
- Testing
- Busulfan, Cyclophosphamide, CXCR4 Antagonist
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Neck Pain, Migraine
Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study
Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life.
- Conditions
- Neck Pain, Migraine, Low Back Pain
- Trial name
- NCT07567300
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people
- Sponsor
- Bozok University
Whiplash Injuries
Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders
The primary study aim is to unravel the nature of impaired pain inhibition during exercise in patients with chronic Whiplash-Associated Disorders (WAD).
- Trial name
- NCT01601912
- Testing
- Atomoxetine, Citalopram
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Asthma, Eczema
Fish Oil Supplementation During Pregnancy for Prevention of Asthma, Eczema and Allergies in Childhood
The aim of this study is to prevent asthma and allergies in childhood by supplementation with fish oil (n-3 fatty acids) to the mother during pregnancy.
- Conditions
- Asthma, Eczema, Allergy
- Trial name
- NCT00798226
- Testing
- n-3 fatty acid, olive oil
- Where
- 2 sites in Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Rheumatoid Arthritis
Central Aspects of Pain in Rheumatoid Arthritis
This study seeks to measure the psychometric properties of a newly developed Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, and investigate the ability of this questionnaire to measure central mechanisms…
- Trial name
- CAP-RA (NCT04515589)
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Nottingham
Cervicogenic Headache, Proprioceptive Disorders
Manual Therapy vs. Multicomponent Exercise in Cervicogenic Headache
The purpose of this study is to compare the effects of manual therapy and a multicomponent exercise program on suboccipital muscle thickness, joint position sense, pain, central sensitization, balance, and kinesiophobia in…
- Conditions
- Cervicogenic Headache, Proprioceptive Disorders, Neck Pain Musculoskeletal
- Trial name
- NCT07776093
- Testing
- Manual Therapy Protocol, Multicomponent Exercise Program
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Cocaine Use Disorder
CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations
This research focuses on behavioral sensitization (BS) a specific behavioural disturbance in crack-cocaine addiction. The primary objective is to observe whether BS can be demonstrated in an ecological setting in crack dependent…
- Trial name
- CRACK-TARGET (NCT06050304)
- Testing
- Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter, 3 blood tests
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Central Sensitisation
Central Sensitization in Medical Students
Central sensitization (SS); is a physiological phenomenon caused by neuronal dysregulation and hyperexcitability in the central nervous system, resulting in hypersensitivity to painful and painless stimuli.Central sensitization…
- Trial name
- NCT05495594
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Dokuz Eylul University
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Fibromyalgia
Phrenic Nerve Infiltration in Fibromyalgia
It is known that nociceptive afferences in visceral pain and visceral disorders increase sensitization in subjects suffering from fibromyalgia. These patients use to present visceral comorbidities.
- Trial name
- NCT05792774
- Testing
- Bupivacain
- Where
- 4 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Ankylosing Spondylitis, Peripheral Neuropathies
Assessment of Peripheral Neuropathy in Ankylosing Spondylitis
investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.
- Trial name
- NCT07641920
- Testing
- Nerve conduction study
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Acute Myeloid Leukemia, Measurable Residual Disease
Motixafortide for MRD Sensitization in AML
This is a pilot phase I study evaluating the effect of motixafortide on determination of measurable residual disease (MRD) level in patients with acute myeloid leukemia (AML) who have completed induction treatment.
- Trial name
- NCT07392970
- Testing
- Motixafortide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Back Pain Lower Back Chronic
Effectiveness of a Psychoeducative Intervention on Patients With Cronic Low Back Pain
One of the treatment modalities currently available in this hospital to treat this type of patients with low back pain who present with chronic pain are the group sessions that are carried out to provide information to the…
- Trial name
- PNE (NCT03964389)
- Testing
- Pain Neuroscience Education" (PNE)
- Where
- Spain
- Volunteers
- 179 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Plantar Fasciitis, Chronic
Comparative Effectiveness of Different Neural Mobilization Techniques in Plantar Fasciitis
BThis study will be designed to compare between the effect of adding posterior tibial nerve or saphenous nerve mobilization to the traditional physical therapy on pain intensity, foot function, pressure pain threshold, ankle…
- Trial name
- RCT (NCT07657533)
- Testing
- nerve mobilization, physical therapy, saphenous nerve mobilization
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Osteoarthritis
fMRI Evaluation of Pain Central Sensitization Phenomena in Subjects With Knee Osteoarthritis
The aim of this project is to investigate fMRI ability to identify pain central sensitization in chronic knee OA. Patients with high and low central sensitization and healthy control subjects will be included.
- Trial name
- NCT01700634
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Low Back Pain
Relationship Between Low Back Pain and Sensitization
Chronic non-specific low back pain is a common health problem that significantly affects the quality of life of individuals. Increased pain intensity leads to deficiencies in the body's sensory organization, resulting in…
- Trial name
- NCT06958263
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Karabuk University