Clinical trials: Sepsis Syndromes
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Intensive Care Unit, Mortality
Analysis of the Evolution of Mortality in an Intensive Care Unit
The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical…
- Conditions
- Intensive Care Unit, Mortality, Epidemiology, Respiration, Artificial
- Trial name
- NCT05261607
- Where
- Spain
- Volunteers
- 27,463 people
- Sponsor
- Hospital Universitario Getafe
Acute Respiratory Distress Syndrome (ARDS)
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial
Acute respiratory distress syndrome (ARDS) is a major cause of acute hypoxemic respiratory failure in critically ill patients and is associated with substantial mortality.
- Trial name
- DEFEND (NCT07576660)
- Testing
- Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 1,704 people
- Sponsor
- Southeast University, China
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
The GRACE-2 study is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with…
- Trial name
- GRACE-2 (NCT05266001)
- Testing
- GM-CSF
- Where
- 25 sites in United States
- Volunteers
- 141 people
- Sponsor
- Nationwide Children's Hospital
Enterovirus, Clinical Syndrome
Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological Insights on Echovirus 11
The Enterovirus genus, belonging to the Picornaviridae family, consists of positively polarized single-stranded RNA viruses classified into the species Enterovirus (EV, comprising Coxsackievirus, Echovirus and Poliovirus) A-J and…
- Conditions
- Enterovirus, Clinical Syndrome, Respiratory Complications, Gastrointestinal
- Trial name
- Entero-Neo (NCT07356583)
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced…
- Trial name
- TRIPS (NCT05267821)
- Testing
- Anakinra
- Where
- 32 sites in United States
- Volunteers
- 500 people
- Sponsor
- Nationwide Children's Hospital
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Shock, Preterm Birth Complication
Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g.
- Conditions
- Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal
- Trial name
- NCT07248761
- Testing
- Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Still's Disease, Adult-Onset, Sepsis
Glycosylated Ferritin in Macrophagic Activation Syndromes
In healthy subjects, from 50 to 80 % of the serum ferritin is glycosylated [1, 2] . A decrease in the percentage of ferritin glycosylation can be observed in inflammatory diseases, malignancies, infections, or liver disease but…
- Conditions
- Still's Disease, Adult-Onset, Sepsis, Macrophagic Activation Syndrome
- Trial name
- FERRITGLY01 (NCT02143986)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Brugmann University Hospital
Systemic Inflammatory Response Syndrome
Goal-directed Resuscitative Interventions During Pediatric Inter-facility Transport (The GRIPIT Trial)
Recent advances in critical care medicine have dramatically improved morbidity and mortality of critical illness. Goal-directed therapy protocols have been instrumental in this change.
- Trial name
- GRIPIT (NCT01293500)
- Testing
- Goal-directed Therapeutic Protocol
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Sepsis, Sepsis, Severe
Does the Phoenix Pediatric Sepsis Prognosis Prediction Scale Work
The aim of this study to understand the compatibility of Phoenix Score, International 2005 SIRS criterias and PRISM III, PELOD scoring systems.
- Trial name
- NCT06539884
- Testing
- Observational
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Oguz Dursun
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia
Respiratory Failure, Acid-Base Balance Disorder
Validation of the Accuracy of a Novel POCT Dry Blood Gas Analyzer in Acute Care Settings
The goal of this observational study is to validate the performance of the novel POCT dry blood gas analyzer EG-i30, against the currently widely used traditional wet blood gas analyzer, Radiometer ABL90, in acute care settings.
- Conditions
- Respiratory Failure, Acid-Base Balance Disorder, Sepsis, Shock
- Trial name
- NCT06726473
- Testing
- Wet Blood Gas Analyzer (ABL90), Dry Blood Gas Analyzer (EG-i30)
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Zhujiang Hospital
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
The Study Seeks to Determine Potential Correlations Between Ventilation and Hematological Alterations, Contributing to a Better Understanding of Its Physiological Effects and Optimizing Patient Management in Critical Care Settings.
The study seeks to determine potential correlations between ventilation and hematological alterations, contributing to a better understanding of its physiological effects and optimizing patient management in critical care…
- Trial name
- NCT07030114
- Testing
- complete blood tests, mechanical ventilation (MV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Critical Illness, Acute Kidney Injury
Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT04033224
- Testing
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
- Where
- 15 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Careggi Hospital
Critical Illness, Acute Kidney Injury
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- GlobalARRT (NCT04580680)
- Testing
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Careggi Hospital