Clinical trials: Septic Shock, completed
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Sepsis, Septic Shock
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million.
- Trial name
- LASSONEO (NCT05707494)
- Testing
- Efferon LPS NEO
- Where
- 7 sites in Russia
- Volunteers
- 78 people
- Sponsor
- Efferon JSC
Supraventricular Arrhythmia, Septic Shock
Propafenone Versus Amiodarone in Septic Shock
Arrhythmias accompany septic shock in increased rates than in other ICU cohorts and their presence and management are related to patient´s prognosis.
- Trial name
- PRASE (NCT03029169)
- Testing
- Propafenone i.v., Amiodarone i.v.
- Where
- 2 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Charles University, Czech Republic
Pneumonia, Viral, Covid19
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19
Introduction: SARS-CoV2 infection produces severe pneumonia with pulmonary alveolar collapse. There is no specific treatment to date.
- Conditions
- Pneumonia, Viral, Covid19, ARDS, Oxidative Stress
- Trial name
- ANTIOX-COVID (NCT04570254)
- Testing
- Vitamin C, Vitamin E, Melatonin
- Where
- Mexico
- Volunteers
- 110 people
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Sepsis, Severe Sepsis
Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions
The German Quality Network Sepsis is an association trying to improve quality of care for patients with sepsis, severe sepsis and septic shock or being in risc thereof.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- icosmos (NCT02820675)
- Testing
- structured case analysis, strucured screening "every patient, every shift"
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Sepsis, Septic Shock
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
The investigators' objective is to compare the risk of treatment failure* in children admitted to the pediatric intensive care unit (PICU) with sepsis and managed by procalcitonin guided therapy for stopping of antibiotics ('PCT…
- Conditions
- Sepsis, Septic Shock, Antibiotic Use, Procalcitonin
- Trial name
- NCT03388944
- Testing
- PCT group
- Where
- 2 sites in India
- Volunteers
- 561 people
- Sponsor
- All India Institute of Medical Sciences
Toxic Shock Syndrome
Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study
Staphylococcus aureus and Streptococcus pyogenes produce many virulence factors. Some of them are responsible for severe infections in humans. Superantigen toxins synthesized by S. aureus or by S.
- Trial name
- IVIG (NCT02219165)
- Testing
- Intravenous human immunoglobulin, Albumin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Outcome of Using Hydrocortisone in Early Treatment of Pediatric Septic Shock
Although, hydrocortisone has shown promise in managing refractory shock, its role in early septic shock management remains unclear.
- Trial name
- NCT07313670
- Testing
- Intravenous Hydrocortisone, Standard care
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Muhammad Aamir Latif
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Meningococcal Infections, Septic Shock
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
- Conditions
- Meningococcal Infections, Septic Shock, Severe Sepsis
- Trial name
- SAMIRA (NCT02041663)
- Testing
- BNP
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Pediatric Infectious Shock
Pediatric Immune Response to Infectious Shock
Infectious shocks are associated with high mortality rates (20-40%). Anti-inflammatory strategies based on the postulate that mortality related to sepsis is mainly due to an overwhelming pro-inflammatory immune response have…
- Trial name
- PedIRIS (NCT02848144)
- Testing
- blood samples, Collection of nosocomial infections
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Septic Shock
Life After Pediatric Sepsis Evaluation
Sepsis represents the leading cause of childhood mortality worldwide. However, as distinct from adult medicine, there exists a large knowledge gap regarding long term health related quality of life (HRQL) and functional status…
- Trial name
- LAPSE (NCT01415180)
- Where
- 11 sites in United States
- Volunteers
- 389 people
- Sponsor
- Seattle Children's Hospital
Sepsis, Shock, Septic
Medical Education for Sepsis Source Control and Antibiotics
Patients with severe sepsis or septic shock suffer from life-threatening infections. Fast and adequate therapy with antibiotics is crucial for survival.
- Trial name
- MEDUSA (NCT01187134)
- Testing
- Change Management
- Where
- 42 sites in Germany
- Volunteers
- 4,138 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Severe Sepsis, Septic Shock
Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring
The purpose of this study was to compare ACCM/PALS guidelines performed with and without central venous oxygen saturation monitoring on the morbidity and mortality rate of children with severe sepsis and septic shock.
- Trial name
- NCT00407823
- Testing
- Central venous oxygen saturation continuous monitoring
- Where
- 2 sites in Brazil
- Volunteers
- 268 people
- Sponsor
- University of Sao Paulo
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences
Critical Illness, Sepsis
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients
Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher…
- Conditions
- Critical Illness, Sepsis, Septic Shock, Ventilator Associated Pneumonia
- Trial name
- SuDDICU (NCT02389036)
- Testing
- SDD Oral Paste, SDD Gastric Suspension, Intravenous Antibiotic
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 20,010 people
- Sponsor
- The George Institute
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether…
- Trial name
- PRoMPT BOLUS (NCT04102371)
- Testing
- Lactated Ringer, Normal Saline, Plasma-lyte
- Where
- 22 sites in United States
- Volunteers
- 9,041 people
- Sponsor
- Children's Hospital of Philadelphia
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Critical Illness
PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
This retrospective multicohort observational study evaluates whether the PaO2/FiO2 ratio (P/F ratio) organizes heterogeneity in the association between early systemic corticosteroid exposure and mortality among critically ill…
- Trial name
- NCT07913464
- Testing
- Systemic Corticosteroids
- Where
- China
- Volunteers
- 2,693 people
- Sponsor
- Shanghai Zhongshan Hospital
Severe Sepsis With Septic Shock
Evaluating a CytoSorb Score in Septic Shock
Systemic hyperinflammatory states, e.g. triggered by infection/sepsis, represent a major challenge for modern medicine. After an initially localized onset, inflammation can extend to an excessive, uncontrolled inflammatory…
- Trial name
- ECSISS (NCT03977688)
- Testing
- Cytokin Adsorption
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Klinikum Emden