Clinical trials: Severe Emphysema
Emphysema or COPD
Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia
Rationale: The Chartis® ( Pulmonx, CA, USA) measurement system is a tool to assess interlobar collateral ventilation during bronchoscopy.
- Trial name
- NCT03205826
- Testing
- Type of sedation used
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Emphysema
Lung Volume Reductions Surgery (LVRS) Study
The main objectives of this study are to see if a type of lung surgery, known as lung reduction surgery, in addition to standard medical treatment improves the quality of life, lung function, and reduces the high mortality…
- Trial name
- NCT00018525
- Testing
- Lung Volume Reduction Surgery
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Emphysema
REACH SVS Control Patient Cross-Over Study
This is a multicenter, prospective study designed to evaluate performance of the SVS in the REACH SVS control patients. The study is expected to enroll up to 20 patients at up to 12 sites with up to 6 patients per site.
- Trial name
- NCT02914340
- Testing
- Spiration Valve System
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Olympus Corporation of the Americas
Emphysema or COPD
Introduction of the Vapor Treatment in The Netherlands
Rationale: The bronchoscopic lung volume reduction treatment using vapor was found to be effective and the treatment has an acceptable safety profile.
- Trial name
- NEVEL (NCT04029077)
- Testing
- NA: intervention is not part of the study
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility.
- Trial name
- NCT01177618
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Brigham and Women's Hospital
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Heterogeneous Emphysema
Endoscopic Lung Volume Reduction After Catheter-based CV Measurement in Patients With Heterogeneous Emphysema and Complete Interlobar Fissures
This clinical trial evaluates the impact of catheter-based measurement of interloabr collateral ventilation prior to endoscopic lung volume reduction in patients with hetereogeneous emphysema and complete interlobar fissures in…
- Trial name
- NCT01902732
- Testing
- Implantation of valves (IBV)
- Where
- 5 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
COPD, Emphysema
A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.
Rationale: The combined data from 3 studies outside the Unites States investigating the Lung Volume Reduction Coil system (RePneu LVRC) showed statistically significant improvements in pulmonary function, exercise capacity and…
- Trial name
- RECOIL (NCT02012673)
- Testing
- Bronchoscopic lung volume reduction
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Alpha-1-antitrypsin Deficiency, Liver Cirrhosis
Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency
The primary objective is to determine if the medication Carbamazepine, can be used as a therapy for patients with severe liver disease due to Alpha-1-Antitrypsin Deficiency .
- Trial name
- CBZ (NCT01379469)
- Testing
- Drug-Carbamazepine (Tegretol XR)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine