Clinical trials: Sexually Transmitted Infections
Papillomavirus Infections
V503 in Chinese Girls 9-14 Years Old Versus Chinese Women 20-26 Years Old (V503-071)
This study aims to demonstrate that a 2-dose regimen of the 9-Valent Human Papillomavirus (9vHPV) vaccine (GARDASIL™9, V503) induces non-inferior competitive Luminex immunoassay (cLIA) geometric mean titers (GMTs) to each of the…
- Trial name
- NCT05450705
- Testing
- 9vHPV vaccine
- Where
- 2 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
IMARA, Adapting SiHLE for Detained African American Adolescent Females
The IMARA Program will test the efficacy of a multi-session HIV Prevention program, adapted from an existing program(SiHLE), for incarcerated African American adolescent females.
- Trial name
- IMARA (NCT00746369)
- Testing
- IMARA HIV Prevention Intervention
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Infections
A Study of Two Methods of Determining When to Begin or Change Anti-HIV Treatment
PRIMARY: To compare the clinical efficacy of two decision making strategies for initiating or changing antiretroviral therapy: decision making based on current clinical practice alone (i.e., initiating or changing therapy based…
- Trial name
- NCT00001069
- Where
- 17 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Optimizing Treatment for Treatment-Experienced, HIV-Infected People
The goal of anti-HIV therapy is to prevent HIV from replicating. Long-term control of HIV requires at least two anti-HIV drugs that are active against the virus.
- Trial name
- NCT00537394
- Testing
- Enfuvirtide, Raltegravir, Darunavir
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 517 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Health Behavior, Health Care Utilization
Evaluation of the SafeSpace App Intervention
The goal of this study is to evaluate the impact of SafeSpace Sexual Health App, an innovative sexual health promotion program focused on reducing sexual risk factors and promoting sexual and reproductive health and wellbeing…
- Conditions
- Health Behavior, Health Care Utilization, Unprotected Sex, Sexually Transmitted Infections
- Trial name
- SafeSpace (NCT06043596)
- Testing
- SafeSpace Sexual Health, SafeSpace General Health
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Child Trends
Infections, Papillomavirus
Evaluation of Safety and Immunogenicity of Co-administering Human Papillomavirus Vaccine With Another Vaccine in Healthy Female Subjects
Infection with human papillomavirus (HPV) has been clearly established as the central cause of cervical cancer. Vaccination of pre-teens and adolescents, ideally before sexual debut and thus before exposure to oncogenic HPV, is a…
- Trial name
- NCT00578227
- Testing
- Cervarix™, Twinrix ™ Paediatric
- Where
- 21 sites in Canada, Denmark and 2 more
- Volunteers
- 814 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections, Cervix, Dysplasia
Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
The purpose of this study is to see if it is safe and effective to give isotretinoin to HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
- Trial name
- NCT00001073
- Testing
- Isotretinoin
- Where
- 40 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
DASH - Decision Making in Adolescent Sexual Health
This is a randomized controlled trial to contrast an intervention that relies on well-developed cognitive control systems (Motivational Interviewing; MI) to an intervention that relies on a more basic response to scheduled reward…
- Trial name
- DASH (NCT02141646)
- Testing
- Motivational Interviewing, Behavioral Skills Training
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Cryptosporidiosis, HIV Infections
A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS
To evaluate the safety and efficacy of diclazuril capsules as a treatment for cryptosporidial related diarrhea in AIDS patients who have been treated in the double-blind study # JRD 64,433/1101 and have relapsed, or de-novo…
- Trial name
- NCT00002278
- Testing
- Diclazuril
- Where
- 3 sites in United States
- Sponsor
- Janssen, LP
HIV Infection, HIV Infections
Preparing for Adolescent HIV Vaccine Trials in South Africa:
This study will use the licensed HPV vaccine, Gardasil, as a surrogate for an HIV vaccine, in order to explore some of the ethico-legal,psycho-social and logistical challenges involved in running an HIV vaccine trial in…
- Trial name
- CATSA (NCT00944879)
- Where
- South Africa
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Centre
HIV Infections
An Open-Label Study of Emtricitabine in Combination With Other Antiretroviral Agents in HIV Infected Pediatric Subjects
To obtain safety and efficacy data for antiretroviral regimens containing emtricitabine in HIV-1 infected pediatric subjects. To determine emtricitabine concentrations in HIV-1 infected pediatric subjects and, if necessary, to…
- Trial name
- NCT00642291
- Testing
- Emtricitabine
- Where
- 2 sites in Romania
- Volunteers
- 16 people
- Sponsor
- Gilead Sciences
Hepatitis C, HIV Infection
Nucleic Acid Amplification Testing (NAT) of Blood Donors for HCV and HIV
This study will evaluate the accuracy of an experimental test method called nucleic acid amplification technology (NAT) in detecting human immunodeficiency virus (HIV) and hepatitis C virus (HCV).
- Trial name
- NCT00004846
- Testing
- ABC/Gen-Probe/Chiron HIV-1/HCV 001
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections
Family-centered HIV Care, Viral Suppression and Retention in HIV-positive Children, Swaziland
The study will evaluate the effect of implementing a family-centered care (FAM-CARE) program (where all HIV-positive family members are seen together as a unit and receive care together) on viral suppression and retention in…
- Trial name
- FAM-CARE (NCT03397420)
- Testing
- FAM-CARE
- Where
- Eswatini
- Volunteers
- 742 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV/AIDS
Peer-led Dynamic Choice HIV Prevention for Women: The Peer-led DCP Pilot Study
This study will refine and pilot test the Peer-led Dynamic Choice HIV Prevention (DCP) intervention in a single-arm pilot trial.
- Trial name
- NCT07298785
- Testing
- Peer-led Dynamic Choice HIV Prevention (DCP) intervention
- Where
- Uganda
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Infections, Chickenpox
Use of a Varicella-Zoster Virus (VZV) Vaccine to Prevent Shingles in HIV-Infected Children Who Have Already Had Chickenpox
The purpose of this study is to see if the varicella-zoster virus (VZV) vaccine will be safe and if it can help prevent shingles in HIV-infected children who have already had chickenpox. VZV is the virus that causes chickenpox.
- Trial name
- NCT00001125
- Testing
- Varicella Virus Vaccine (Live)
- Where
- 22 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Pediatric Decentralization of ART in South Africa
The decentralization study will describe children taking antiretroviral therapy (ART) at a larger health facility in the Eastern Cape province of South Africa, between the years of 2004-2013.
- Trial name
- NCT03049891
- Testing
- Data abstraction, Tracing questionnaire, Tier.net
- Where
- 15 sites in South Africa
- Volunteers
- 1,583 people
- Sponsor
- Columbia University
HIV Infections
Factors Affecting Adherence to Anti-HIV Drug Regimens in Children and Adolescents
Taking anti-HIV medication consistently and properly is a critical issue for patients with HIV. Drug regimens are complex; when regimens are not taken properly, HIV can become resistant to the drugs.
- Trial name
- NCT00073424
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
HUSH Restriction in HIV Infected Patients
HIV eradication faces a major obstacle that is viral persistence in latent reservoir cells despite antiretroviral therapy. Epigenetic repression plays a central role in viral transgene latency and several epigenetic regulators…
- Trial name
- NCT04172480
- Testing
- Blood sampling
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, Hodgkin's Disease
Phase II Study of Filgrastim (G-CSF) Plus ABVD in the Treatment of HIV-Associated Hodgkin's Disease
Primary: To assess the toxicity of chemotherapy with ABVD (doxorubicin / bleomycin / vinblastine / dacarbazine) when given with filgrastim ( granulocyte colony-stimulating factor; G-CSF ) in patients with underlying HIV infection…
- Trial name
- NCT00000626
- Testing
- Vinblastine sulfate, Dacarbazine, Filgrastim
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
DTG/3TC Fixed Dose Formulations for the Maintenance of Virological Suppression in Children With HIV Infection Aged 2 to <15 Years Old
This study aims to find out whether treating children and young people living with HIV with two anti HIV medicines, dolutegravir and lamivudine, is safe and as effective as the three-medicine anti-HIV treatments currently used in…
- Trial name
- D3 (Penta21) (NCT04337450)
- Testing
- Dolutegravir (DTG) and lamivudine (3TC), SOC
- Where
- 14 sites in South Africa, Spain and 3 more
- Volunteers
- 386 people
- Sponsor
- PENTA Foundation
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