Clinical trials: Skeletal Disorder
Achondroplasia
An Extension Study to Evaluate the Efficacy and Safety of BMN 111 in Children With Achondroplasia
The intent and design of this Phase 3 study is to assess BMN 111 as a therapeutic option for the treatment of children with Achondroplasia
- Trial name
- NCT03424018
- Testing
- BMN 111
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 119 people
- Sponsor
- BioMarin Pharmaceutical
Fibrous Dysplasia
Study of Denosumab for Prevention of Skeletal Disease Progression in Children With Fibrous Dysplasia
Background: Fibrous dysplasia (FD) is a disease that affects the bones. It causes bone lesions that can become weak and lead to fractures, deformity, and nerve injuries.
- Trial name
- NCT05419050
- Testing
- denosumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Class II Malocclusion
The Effect of Low-level Laser Therapy on Functional Treatment of Skeletal Class II Patients
this is a controlled clinical trial with 2 groups of patients of class II skeletal discrepancy due to mandibular retrusion one group is treated with twin block functional appliance and the other with twin block combined with low…
- Trial name
- NCT06024382
- Testing
- twin block, twin block combined with low level laser
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Skeletal Class III Malocclusion
Efficacy of RME and Facemask Therapy for Class III Malocclusion
This multicenter randomized controlled trial compares the efficacy of Rapid Maxillary Expansion (RME) combined with facemask (FM) protraction versus FM protraction alone in treating growing children with skeletal Class III…
- Trial name
- NCT07053683
- Testing
- Combined RME and Facemask Therapy, Facemask Therapy Alone
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Wuhan Integrated Traditional Chinese and Western Medicine Hospital
Class III Malocclusion
Treatment of Skeletal Class III Malocclusion Using Orthodontic Removable Traction Appliance
This experimental study aims to evaluate the efficiency of the orthodontic removable traction appliance in the treatment of skeletal class III malocclusion.
- Trial name
- NCT03172442
- Testing
- Vacuum plate, Rapid maxillary expander, Class III elastics
- Where
- Syria
- Volunteers
- 22 people
- Sponsor
- Damascus University
Skeletal Class II Malocclusion, Mandibular Retrognathia
Fixed Versus Conventional Twin Block Appliances for Skeletal Class II Malocclusion
This study compares two types of dental appliances a fixed Twin Block appliance and a conventional (removable) Twin Block appliance used to treat a bite problem called skeletal Class II malocclusion in growing children and…
- Trial name
- NCT07687927
- Testing
- Conventional Twin Block Appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Traumatic Injuries
Utility of Whole-body MRI in the Detection of Traumatic Injuries of Undetermined Origin in Children
The diagnosis of abuse in children relies heavily on the presence of skeletal and extraskeletal injuries. However, some lesions are not seen by initial skeletal survey.
- Trial name
- PEDIMA (NCT01743703)
- Testing
- diagnostic whole body MRI
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Rennes University Hospital
Hypochondroplasia
Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children
This study is conducted to describe the efficacy and safety of recombinant human growth hormone (r-hGH) treatment Saizen® on children with hypochondroplasia.
- Trial name
- NCT01111019
- Testing
- Recombinant human growth hormone (r-hGH)
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Developmental Delay, Skeletal Abnormalities
Biomarker for Sly Disease (MPS VII) (BioSly)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Sly disease from blood (plasma)
- Conditions
- Developmental Delay, Skeletal Abnormalities, Hepatomegaly, Splenomegaly
- Trial name
- BioSly (NCT02298699)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Three Dimensional, Dento-Skeletal
Three Dimensional Evaluation of Dento-Skeletal Effects of Leaf Self Expander in Cleft Lip and Palate Patients
This study aims to evaluate the dento-alveolar changes after maxillary expansion in cleft lip and palate patients by Leaf Self Expander, as compared to conventional Rapid Maxillary Expander using digital cast analysis and…
- Conditions
- Three Dimensional, Dento-Skeletal, Leaf Self Expander, Cleft Lip
- Trial name
- NCT07384338
- Testing
- Rapid maxillary expansion, Leaf Self Expander
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Class II Malocclusion
Clinical Effects of Electrical Stimulation on Speeding up Orthodontic Tooth Movement
Thirty two patients requiring extraction of maxillary first premolars and en-masse retraction of upper anterior teeth will participate in the study.
- Trial name
- NCT05302076
- Testing
- Low-intensity electrical current (LIEC), Traditional fixed orthodontic appliance
- Where
- Syria
- Volunteers
- 32 people
- Sponsor
- Damascus University
Class III Malocclusion
Treating Growing Patients With Mandibular Prognathism and Maxillary Constriction
This randomized controlled trial intends to test the efficacy of two treatment protocols in the correction of Class III malocclusion with maxillary constriction.
- Trial name
- NCT06762418
- Testing
- RMR+SME, BAIMT+RME
- Where
- 2 sites in Syria
- Volunteers
- 26 people
- Sponsor
- Damascus University
Cutaneous Skeletal Hypophosphatemia Syndrome (CSHS), Epidermal Nevus Syndrome
Burosumab for CSHS
Burosumab (also known as the drug, Crysvita®) is a fully human immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that binds to and inhibits the activity of fibroblast growth factor 23 (FGF23), leading to an increase in serum…
- Trial name
- NCT03993821
- Testing
- Burosumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Laura Tosi
Class III Malocclusion in Growing Patients
Changes Following the Treatment of Lower Jaw Protrusion Using Two Appliances
An in vivo study evaluating the efficacy of the Tandem appliance in the treatment of maxillary deficiency in growing patients compared to the conventional facemask appliance treatment.
- Trial name
- NCT02144324
- Testing
- Tandem Appliance
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Abdominal Obesity
Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, and risk of type 2 diabetes…
- Trial name
- NCT00739180
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Masseter, Ultrasonography
Masseter Muscle Thickness and Craniofacial Skeletal Patterns
Facial morphology is influenced by hard and soft tissues, including bone and muscle. While numerous factors can lead to changes in bone tissue, soft tissues such as muscle also have an important influence.
- Conditions
- Masseter, Ultrasonography, Malocclusions, Cephalometry
- Trial name
- NCT06870084
- Testing
- Ultrasonography, Lateral cephalometric radiography, Facial photograph
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Malocclusion, Angle Class II, Retrognathism
The Effect of Functional Treatment of Patients With Backward Positioned Chins on the Jaw Joint and Movements
Patients with class II malocclusion and retrognathic mandibles will be treated using functional appliances and asses the remodeling that is expected to occur in the temporomandibular joint (TMJ) using cone-beam computed…
- Conditions
- Malocclusion, Angle Class II, Retrognathism, TMJ
- Trial name
- NCT03645343
- Testing
- Activator, Twin Block
- Where
- Syria
- Volunteers
- 66 people
- Sponsor
- Damascus University
Malocclusion, Angle Class II, Division 1
Evaluation of Mini Plates Anchorage With Forsus Fatigue Resistant Device
The purpose of this study is to determine if the Forsus Fatigue resistant Device appliance with direct skeletal mini plates anchorage is capable of achievement of skeletal mandibular effects while preventing the excessive…
- Trial name
- NCT02475785
- Testing
- FFRD and mini plates group, Conventional FFRD
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sherif A. Elkordy
Hypochondroplasia
Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia
The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).
- Trial name
- CANOPY-HCH-3 (NCT06455059)
- Testing
- Vosoritide
- Where
- 23 sites in United States, Australia and 7 more
- Volunteers
- 80 people
- Sponsor
- BioMarin Pharmaceutical