Clinical trials: Skeletal Disorder
Mitochondrial Diseases
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
- Trial name
- NCT03351998
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Metastatic Non-small Cell Lung Cancer, Neoplasm
Body Composition and Inflammatory-Metabolic Indices in Immunotherapy-Treated Metastatic Non-Small Cell Lung Cancer: The SARC-CTI Study
This retrospective, single-center observational cohort study evaluates inflammatory-metabolic, cachexia-related, and computed tomography (CT)-derived body-composition markers in patients with metastatic non-small cell lung cancer…
- Trial name
- SARC-CTI (NCT07192926)
- Testing
- Immune Checkpoint Inhibitor-Based Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 155 people
- Sponsor
- Ankara Etlik City Hospital
Hypertension, Abdominal Obesity
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension
Part 1 determined: aliskiren, amlodipine and angiotensin II concentrations in interstitial fluid of fat and skeletal muscle; aliskiren and angiotensin II concentrations, and renin activity and concentration in fat and skeletal…
- Trial name
- NCT00498433
- Testing
- Aliskiren, Amlodipine
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- Novartis
Ischemic Heart Failure, Ischemic Heart Disease
Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed From the Thigh Muscle) Into Scarred Areas of Heart Muscle After Heart Attack.
Study to examine the safety and effectiveness of implanted skeletal muscle cells (cells removed from the thigh muscle) into scarred areas of heart muscle after heart attack.
- Conditions
- Ischemic Heart Failure, Ischemic Heart Disease, Ischemic Cardiomyopathy
- Trial name
- NCT00102128
- Testing
- Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation)
- Where
- 28 sites in Belgium, France and 4 more
- Sponsor
- Genzyme, a Sanofi Company
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Fraility, Nutrition Assessment
Assessing the Relationship Between Frailty and Skeletal Muscle Thickness in Critically Ill Patients
Assessment of muscle mass in critically ill patients is critical for both improving clinical outcomes and monitoring the effectiveness of nutritional interventions.
- Conditions
- Fraility, Nutrition Assessment, Ultrasound Evaluation, Critical Illness
- Trial name
- NCT07310667
- Testing
- Muscle ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Training and Research Hospital
Insulin Resistance, Type 2 Diabetes Mellitus
(Mol-SHARE) Molecular Study of Health Assessment and Risk in Ethnic Groups
The purpose of this study is to directly compare the body composition, body fat distribution, and morphological and functional features of adipose tissue and skeletal muscle between South Asians and European Caucasians.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- NCT00249314
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Diabetic Foot Ulcer, Therapy, Directly Observed
Nocardia Cell Wall Skeleton for the Treatment of Diabetic Foot Ulcer Wounds
This study was to investigate the efficacy and safety of Nocardia rubra Cell Wall Skeleton (NCWS) in the treatment of diabetic foot ulcer wounds. The study was a prospective, randomized, controlled, multicentre study .
- Trial name
- NCT05368142
- Testing
- Nocardia rubra Cell Wall Skeleton, Silver ions dressing
- Volunteers
- 116 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Pulmonary Artery Hypertension
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH
Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure.
- Trial name
- NCT03979482
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
PRescription Exercise for Older Men With Urinary Disease
This is a single-center pilot randomized controlled trial among 68 physically "inactive" older men with lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (LUTS/BPH) assessing a 12-week remote exercise…
- Trial name
- PROUD (NCT06225479)
- Testing
- Exercise, Calls and Newsletter
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Francisco
Pain, Bone Neoplasm
A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.
This single arm study will assess the efficacy of loading doses of intravenous Bondronat in reducing pain in patients with breast cancer and metastatic bone disease experiencing moderate to severe bone pain.
- Conditions
- Pain, Bone Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00478270
- Testing
- ibandronate [Bondronat]
- Where
- 6 sites in Greece
- Sponsor
- Hoffmann-La Roche
Heart Failure
Effects of Epicatechin on Functional Capacity, Skeletal Muscle Structure and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction (HFPEF)
The major goal of this proposal is to characterize the ability of epicatechin which a component of dark chocolate to improve the 1. structural and functional features of skeletal muscle (SkM) 2.
- Trial name
- HFPEF (NCT02068040)
- Testing
- CocoaVia
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Obesity, Sarcopenia
Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle
Obesity in humans has been shown to result in the increased release of small inflammatory-inducing proteins, called cytokines, from the fat cells of the body.
- Trial name
- NCT02305069
- Testing
- Pioglitazone, Insulin, Octreotide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Skeletal Abnormalities, Psychomotor Retardation
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Mucolipidosis Disorder type I,II,III or IV from blood (plasma)
- Trial name
- BioML (NCT02298673)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Skeletal Class II Malocclusion, Dental Overjet
Removable Devices in Overjet Reduction
The goal of this clinical trial si to compare two removable devices used to treat the mandibular retrusion in growing patients. The main questions it aims to answer are: the efficacy of the two devices in the reduction of the…
- Trial name
- RemoDevOJ (NCT06955637)
- Testing
- dental movement
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Obesity (Disorder), Obesity
Effect of Vitamin D on Body Composition and Functionality of Older Adults
Older adults with obesity often experience a gradual loss of muscle mass and muscle strength, a condition sometimes described as sarcopenic obesity.
- Conditions
- Obesity (Disorder), Obesity, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT07275177
- Testing
- Vitamin D
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
Sarcopenia
Lysosomal Movement and Anabolic Resistance
Age-associated loss of muscle mass, termed sarcopenia, is strongly associated with functional impairment and physical disability in the elderly.
- Trial name
- NCT03032757
- Testing
- Essential amino acids
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Iron Deficiency Anemia
Impact of Intravenous Iron on Musculoskeletal Function in Older Adults
Anaemia is a risk factor for functional decline and frailty in older adults including decreased physical performance and muscle strength, increased hospitalisation risk and mortality, falls, and poorer recovery from activities of…
- Trial name
- FERIDA (NCT05708170)
- Testing
- Ferinject, Ferrous Sulfate 200 MG
- Volunteers
- 100 people
- Sponsor
- Liverpool Hope University