Clinical trials: Sleep-Disordered Breathing
Sleep-disordered Breathing
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing
Our goals are to demonstrate an active leukotrienes (LTs) mediated inflammatory response is involved in pathophysiology of sleep-disordered breathing (SDB), and to provide a theoretical evidence for LTs modify therapy in treating…
- Trial name
- NCT01344746
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Beijing Children's Hospital
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Obstructive Sleep Disordered Breathing
Outcomes of Partial Versus Complete Tonsillectomy for Obstructive Sleep Disordered Breathing
Introduction: There is currently no long-term study, which compares the outcomes of partial tonsillectomy to conventional tonsillectomy.
- Trial name
- NCT00519402
- Testing
- tonsillar examination and questionnaire completion
- Where
- United States
- Sponsor
- The Cleveland Clinic
Asthma in Children, Electromyography
Continuous EMG Measurements in Children With Asthma During Sleep
The objective of this study is to investigate whether electromyography of the diaphragm during sleep in asthmatic children can be used to objectively monitor asthma control.
- Conditions
- Asthma in Children, Electromyography, Sleep-Disordered Breathing
- Trial name
- NCT05547477
- Volunteers
- 20 people
- Sponsor
- Medisch Spectrum Twente
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Down Syndrome, Sleep Disordered Breathing
Healthy Sleep for Children With Down Syndrome
The purpose of this multi-center observational study (utilizing the sites enrolling patients for the Pediatric Adenotonsillectomy Trial for Snoring (PATS) [1U011HL125307-O1A1]) is to gather data regarding children with Down…
- Trial name
- HELP-DS (NCT03922165)
- Testing
- Adenotonsillectomy
- Where
- 6 sites in United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Sleep-disordered Breathing (SDB)
Sleep-disordered Breathing and Neurocognitive Assessment in Children and Young Adults
One of main problems in the management of sleep-disordered breathing (SDB) in children and young adults is their screening, and the absence or the weak correlation between clinical symptoms and polysomnography (PSG).
- Trial name
- TRSPed (NCT04971850)
- Testing
- Sleep study
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, Hypertension
Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure
The purpose of this study is to identify whether sleep-disordered breathing - as measured by overnight polysomnography - is associated with pre-eclampsia and to determine whether use of positive airway pressure can improve…
- Trial name
- NCT01029691
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Sleep Apnea, Sleep Apnea Syndromes in Children
Assessing the Performance of Wesper Lab for Sleep Apnea Diagnosis in Pediatric Populations
The goal of this single arm study is to evaluate the effectiveness of Wesper Lab, previously known as TatchSleep Pro, a wireless home sleep test, as a tool to aid in sleep apnea diagnosis as compared to an overnight…
- Conditions
- Sleep Apnea, Sleep Apnea Syndromes in Children, Sleep Apnea Syndromes
- Trial name
- NCT06218186
- Testing
- Medical Device: Wesper Lab Home Sleep Test
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wesper Inc
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Obstructive Sleep Apnea of Child
Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.
Pediatric obstructive sleep apnea (OSA) can lead to severe health issues if untreated. While polysomnography is the gold standard for diagnosis, current surgical treatment in Denmark relies on caregiver reports and clinical…
- Trial name
- DISE (NCT06093802)
- Testing
- Drug-induced Sleep Endoscopy findings (identified obstruction sites)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Regional Hospital West Jutland
Epilepsy, Obstructive Sleep Apnea
Investigation of Sleep Quality and Prevalence of Sleep-disordered Breathing in Children and Young People With Epilepsy
Obstructive sleep apnoea (OSA) is a condition that affects around one in 20 children. In children with OSA, repeated episodes of airway obstruction can severely disturb and fragment sleep, leading to subsequent cognitive and…
- Trial name
- NCT03103841
- Testing
- Sleep studies [Polysomnography]
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Anemia, Sickle Cell, Sleep-Disordered Breathing
SMILES: Study of Montelukast in Sickle Cell Disease
Sickle cell disease (SCD) is a genetic blood condition causing long term health problems including pain and brain problems which affect quality of life.
- Trial name
- SMILES (NCT04351698)
- Testing
- Montelukast
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Lung Diseases, Sleep Apnea Syndromes
Epidemiology of Sleep Disordered Breathing in Children
To collect fundamental data regarding the distribution of measures of sleep disordered breathing (SDB) in a pediatric population, prevalence of clinically significant SDB in children, risk factors, and associated co-morbidity.
- Trial name
- NCT00005516
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sleep Disordered Breathing
Continuous Positive Airway Pressure and Cardiometabolic Risk
The hypothesis for this study is that children with sleep disordered breathing will benefit from treatment with Continuous Positive Airway Pressure (CPAP) or Bi-level Positive Airway Pressure (BiPAP) in terms of reduction in…
- Trial name
- NCT01403194
- Testing
- CPAP/BiPAP
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic
Sleep Apnea Syndromes, Sleep Disorder
WatchPAT Device Validation Study Compared to Polysomnography
Validation study of a novel sleep Device compared to a traditional sleep study.
- Conditions
- Sleep Apnea Syndromes, Sleep Disorder, Sleep
- Trial name
- WPAT (NCT03188718)
- Testing
- WatchPAT Intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Sleep Disordered Breathing, Drug Induced Sleep Disorder
DISE in Pediatric Sleep Disordered Breathing
Adenotonsillar hypertrophy is the most common reason for children to have sleep disordered breathing (SDB). Even though adenotonsillectomy improves sleep apnea in children, 20-40% of children will still have persistent SDB.
- Trial name
- NCT06756971
- Testing
- Propofol, Dexmedetomidine
- Sponsor
- University of Iowa
Obstructive Sleep Apnea
Tongue Muscular Assessment in Children With Sleep Disordered Breathing
Obstructive sleep apnea (OSA) is part of the sleep-disordered breathing spectrum. Its prevalence in children is 1-5%, and it can have negative consequences at the cardiovascular, cognitive as well as behavioral levels.
- Trial name
- TMAC-C (NCT07273019)
- Testing
- Tongue Strength Assessment, Polysomnography, Subjective Assessment of Sleep-Disordered Breathing
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Hospices Civils de Lyon
Sleep-Disordered Breathing
Pediatric Adenotonsillectomy Trial for Snoring
The purpose of this study is to evaluate the effects of early adenotonsillectomy (eAT) on the behavior, sleep-disordered breathing symptoms and quality of life for children who snore, but do not have obstructive sleep apnea, as…
- Trial name
- PATS (NCT02562040)
- Testing
- Early Adenotonsillectomy (eAT), Watchful Waiting with Supportive Care (WWSC)
- Where
- 7 sites in United States
- Volunteers
- 459 people
- Sponsor
- Brigham and Women's Hospital