Clinical trials: Sore-throat
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tonsillitis
Perioperative Tonsillectomy Protocol Development
Pediatric patients who are undergoing a tonsillectomy at the Children's hospital will be randomly assigned to one of three drug groups: 1) acetaminophen (Tylenol) administered pre-operatively and a low dose of anti-inflammatory…
- Trial name
- NCT03323047
- Testing
- Acetaminophen, Low-dose Dexamethasone, High-Dose Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Pharyngotonsillitis
Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients
The purpose of this study is to evaluate the inflammatory symptoms and signs (hyperemia, edema and pain) reduction after 24 hours of treatment with ketoprofen drops when associated to amoxicillin.
- Trial name
- DROPS (NCT00799838)
- Testing
- Ketoprofen, Amoxicillin
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- Sanofi
Pharyngitis
Efficacy and Safety of Meloxicam Suspension Versus Diclofenac Suspension or Nimesulide Suspension in Patients With a Diagnosis of Acute, Non-bacterial Pharyngitis, Pharyngotonsillitis or Laryngitis
The objective of this study was to assess the clinical efficacy and safety of meloxicam suspension 0.25 mg/kg/day once a day, versus diclofenac suspension 1 mg/kg/day twice a day or nimesulide suspension 4 mg/kg/day twice a day…
- Trial name
- NCT02229747
- Testing
- Meloxicam, Diclofenac, Nimesulide
- Volunteers
- 128 people
- Sponsor
- Boehringer Ingelheim
Acute Otitis Media (AOM), Strep Pharyngitis
Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma
This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma…
- Conditions
- Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
- Trial name
- NCT07500532
- Testing
- Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medentum Innovations
Tonsillitis
Influence of 0.75% Ropivacaine Topicalization on Emergence Agitation in Children
Emergence agitation (EA) is highly prevalent in children after surgery. Risk factors for EA are Eye, nose and throat (ENT) surgery, preoperative anxiety, postoperative pain.
- Trial name
- NCT02848287
- Testing
- normal saline, ropivacaine
- Volunteers
- 84 people
- Sponsor
- Ajou University School of Medicine
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Postoperative Nausea and Vomiting, Sore-throat
Do Throat Pack Used in Dental Treatments Under General Anesthesia of Patients Have an Effect on PONV and Sore Throat?
The aim of this study is to investigate the effect of throat packs on PONV in dental treatments under general anesthesia in special health care needs.
- Conditions
- Postoperative Nausea and Vomiting, Sore-throat, Dental Caries
- Trial name
- NCT06169306
- Testing
- throat pack
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Tonsillitis, Streptococcus Pharyngitis
Antimicrobial Stewardship Program (ASP) in Patients With a Sore Throat
The investigators have developed an antibiotic stewardship program (ASP) to increase adherence to the Swedish guidelines for managing patients with a sore throat.
- Conditions
- Tonsillitis, Streptococcus Pharyngitis, Sore Throat, Pharyngitis
- Trial name
- ASP-Throat (NCT03408704)
- Testing
- ASP
- Where
- Sweden
- Volunteers
- 49 people
- Sponsor
- Vastra Gotaland Region
Sore Throat, Cough
Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of
ABSTRACT: The aim of this study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence.
- Trial name
- NCT02114021
- Testing
- betamethasone gel, lidocaine jelly, distilled water
- Where
- Iran
- Volunteers
- 99 people
- Sponsor
- Tehran University of Medical Sciences
Acute Respiratory Tract Infection, Ear Infection
Enhanced Telemedicine in Primary Care for Acute Respiratory Tract Infections Study
Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed…
- Conditions
- Acute Respiratory Tract Infection, Ear Infection, Throat Infection, Acute Respiratory Tract Infections
- Trial name
- Tele-PARTI (NCT07845526)
- Testing
- Tele-Otoscope Enabled Primary Care, eBook-supported primary care
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Pittsburgh
Recurrent Tonsillitis in Children
A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis
The study objectives are to evaluate Tonsitin™ (10% Lactic Acid) safety, tolerability and preliminary efficacy, as a potent treatment for Recurrent Tonsillitis in children.
- Trial name
- NCT01988558
- Testing
- DL - Lactic Acid, Raspberry flavored syrup
- Where
- 3 sites in Israel
- Volunteers
- 51 people
- Sponsor
- Yali Pharmaceuticals
Tonsillitis
Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children
The primary objective of this study is to demonstrate the non-inferiority, at the assessment visit (V3 (D10/D14)), in terms of bacteriological efficacy of pristinamycin (PRI) administered for 4 days versus amoxicillin (AMX)…
- Trial name
- PRI-angine (NCT00393744)
- Testing
- pristinamycin, amoxicillin
- Where
- France
- Volunteers
- 395 people
- Sponsor
- Sanofi
Streptococcal Infections
Rapid Strep Testing in Children With Recent Streptococcal Pharyngitis
The purpose of this study is to determine if the rapid antigen detection test for Group A streptococcal pharyngitis diagnosis might yield higher rates of false positive results in patients who have been treated for GAS…
- Trial name
- NCT03055728
- Testing
- Rapid strep antigen detection test, throat culture
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Georgetown University
Group A Streptococcal Infection
Pilot Study of Strepic® Device for the Diagnosis of Group A Streptococcal Pharyngitis
The objective of this pilot study is to acquire images using the Strepic® device, a clinical prototype that has been designed specifically as a viable, low-cost, commercially realizable autofluorescence-based diagnostic test…
- Trial name
- NCT03777098
- Testing
- Strepic® Device
- Where
- United States
- Volunteers
- 426 people
- Sponsor
- David A. Talan
Streptococcus Pyogenes Infection, Pharyngitis
Clinical Performance of the Checkable Medical At-Home Strep A Test
The Checkable Medical At-Home Strep A Test is a rapid chromatographic immunoassay for the qualitative detection of Group A Strep (GAS) antigens from throat swabs.
- Conditions
- Streptococcus Pyogenes Infection, Pharyngitis, Respiratory Tract Infections
- Trial name
- NCT05107362
- Testing
- untrained lay user performs investigational diagnostic test
- Where
- 22 sites in United States
- Volunteers
- 1,347 people
- Sponsor
- Checkable Medical Inc
Pharyngitis, Respiratory Diseases
The Efficacy and Safety of Using the Novel Tyto Device
To investigate the efficacy and safety of using the novel Tyto device for remote physical examination by co-investigators as compared to a standard medical physical examination by physicians.
- Conditions
- Pharyngitis, Respiratory Diseases, Cardiac Diseases, Ear Infection
- Trial name
- NCT02723890
- Testing
- Tyto Device
- Where
- Israel
- Volunteers
- 136 people
- Sponsor
- Rabin Medical Center
Obstructive Sleep Apnea, Tonsillitis
Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.
- Trial name
- NCT04230681
- Testing
- Hydromorphone, Fentanyl
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Anesthesia, Opioid Use
Opioid-Free Anesthetic for Tonsillectomy
Prospective randomized controlled trial to determine if opioid-free anesthetic for tonsillectomy is non-inferior to standard opioid-containing anesthetic
- Conditions
- Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder
- Trial name
- NCT04528173
- Testing
- Ketorolac, Dexmedetomidine, Morphine
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia