Clinical trials: Spasticity, Muscle
Bilateral Spastic Cerebral Palsy, Cerebral Palsy
Effect of Treadmill Gait Training Combined With Conventional Physiotherapy on Gait Performance and Functional Mobility in Children With Bilateral Spastic Cerebral Palsy: A Randomized Controlled Trial
Cerebral palsy is a neurological condition that affects movement, muscle control, and walking ability in children. Children with bilateral spastic cerebral palsy often experience increased muscle stiffness, difficulty with…
- Conditions
- Bilateral Spastic Cerebral Palsy, Cerebral Palsy, Spasticity Due to Cerebral Palsy, Gait Abnormality
- Trial name
- GAIT-CP (NCT07683338)
- Testing
- Treadmill Gait Training, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Syeda Khatoon e Jannat Welfare Foundation
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
- Trial name
- NCT02327845
- Where
- 15 sites in United States, Germany and 1 more
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cerebral Palsy, Spastic, Diplegic
The Effects of Traditional Massage on Spasticity and Activity of Children(2 to 10 Years) With Cerebral Palsy
The study has been conducted to see the effects of traditional massage on spasticity and activity of children with cerebral palsy (CP). It is a randomized controlled trial having two groups, control and intervention.
- Trial name
- NCT03771599
- Testing
- Intervention Group, Control group
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Isra University
Spasticity
Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticity
The purpose of this study is to compare the effectiveness between two commercial formulations of botulinum toxin type A in the treatment of spasticity through the Ashworth scale.
- Trial name
- NCT00819065
- Testing
- Botulinum toxin type A from laboratory Lanzhou, Botulinum toxin type A from laboratory Allergan
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Muscular Dystrophies, Muscle Myopathies
Genetic and Physical Study of Childhood Nerve and Muscle Disorders
Background: Some nerve and muscle disorders that start early in life (before age 25), like some forms of muscular dystrophy, can run in families. However, the genetic causes of these disorders are not known.
- Conditions
- Muscular Dystrophies, Muscle Myopathies, Hereditary Spastic Paraplegias, Inherited Neuropathies
- Trial name
- NCT01568658
- Where
- United States
- Volunteers
- 2,586 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blepharospasm, Torticollis
MDs on Botox Utility (MOBILITY)
The MOBILITY Project is a prospective, non-randomized, observational, multi-centre evaluation of Health Utility via the SF-12® Health Survey Scores and the SF-6D in patients receiving BOTOX® for therapeutic use.
- Conditions
- Blepharospasm, Torticollis, Strabismus, Muscle Spasticity
- Trial name
- NCT00535938
- Testing
- botulinum toxin type A
- Where
- Canada
- Volunteers
- 1,372 people
- Sponsor
- Allergan
Cerebral Palsy (CP), Cerebral Palsy, Hemiplegic
Effect of Whirlpool Therapy Combined With Botulinum Toxin in Children With Cerebral Palsy
This study aims to investigate the effects of adding whirlpool therapy to standard rehabilitation in children with cerebral palsy who recently received botulinum toxin-A injections.
- Trial name
- NCT07690722
- Testing
- Conventional Rehabilitation, Whirlpool Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ankara Etlik City Hospital
Muscle Spasticity, Stroke Sequelae
Comparison of Two Botox Injection Techniques to Improve Gait
According to our hypothesis, the use of HD-EMG shall allow an accurate localization of the innervations zones of the muscles, offering a better complement to the methodology applied so far to define the botulinum neurotoxin…
- Conditions
- Muscle Spasticity, Stroke Sequelae, Spasticity as Sequela of Stroke, Gait Disorders, Neurologic
- Trial name
- NCT07124806
- Testing
- Botulinum toxin guided by ultrasonography and anatomical references, Botulinum neurotoxin guided by ultrasonography and in vivo location of innervation zones guided by high-density electromyography
- Where
- 2 sites in Chile
- Volunteers
- 18 people
- Sponsor
- Universidad de los Andes, Chile
Cerebral Palsy
Effects of Play Based Neural Mobilisation Activities on Hand Grip Strength and Dexterity in Cerebral Palsy Children
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis.
- Trial name
- NCT07428928
- Testing
- neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment., Regular physical therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Cerebral Palsy
The Effect of Selective Dorsal Rhizotomy on a Multidimensional Outcome Set in Children With Spastic Cerebral Palsy: a Retrospective Study
Cerebral palsy or CP is the single largest cause of childhood physical disability, with a prevalence of 2-3 per 1000 livebirths.
- Trial name
- NCT06340425
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sialorrhea, Spastic Cerebral Palsy (sCP)
Effect of SCS Technique on Oromotor Skills in Children With CP
This study evaluates the clinical efficacy of the Strain Counter-Strain (SCS) technique on improving oromotor functions in children with spastic cerebral palsy.
- Conditions
- Sialorrhea, Spastic Cerebral Palsy (sCP), Strain Counterstrain Technique, Oral Motor Functions
- Trial name
- NCT07516860
- Testing
- Strain Counter-Strain (SCS), Designed Oral Motor Program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cerebral Palsy, Spastic
Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic and Mesenchymal Stem Cells in Cerebral Palsy
Cerebral palsy(CP) consisted of a group of developmental disability in the field of motor function and is one of the major problems of pediatric neurology and at the present time there is no standard curative medical or surgical…
- Trial name
- NCT03795974
- Testing
- MNC, MSC, Control
- Where
- 4 sites in Iran
- Volunteers
- 108 people
- Sponsor
- Tehran University of Medical Sciences
Hemiplegia and/or Hemiparesis Following Stroke
Exercise to Improve Sleep and Quality of Life in Stroke Patients Receiving Botulinum Toxin Treatment
This study aimed to investigate the contribution of aerobic exercise programmes to improving sleep quality, quality of life, and functional status, alongside conventional rehabilitation, in stroke patients who had received…
- Trial name
- NCT07369453
- Testing
- Aerobic exercise training using a cycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Children With Cerebral Palsy
The Effect of Nervus Vagus Stimulation on Spasticity, Autonomic Function, Motor Function and Quality of Life in Children With Spastic Cerebral Palsy
Introduction: Cerebral palsy (CP) is a heterogeneous neurodevelopmental syndrome affecting muscle tone, motor skills, and movement due to brain injury during developmental stages.
- Trial name
- NCT07165665
- Testing
- Bobath (Neurodevelopmental Treatment) approach, Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
Spasticity, Cerebral Palsy
Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCT
Spasticity is a motor disorder that can affect the lower limbs in up to 75% patients with cerebral palsy, having a significantly effect on their mobility and quality of life.
- Trial name
- NCT02400619
- Testing
- shock waves, Botulinum Toxin Type A
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Xavi Vidal Novellas
Spastic Cerebral Palsy
Effects of Low Frequency Magnet Therapy on Spasticity in Patients With Cerebral Palsy
Background: Spasticity is a major challenge in patients with cerebral palsy (CP). It may cause unwanted complications and may affect the patient's quality of life.
- Trial name
- NCT05242796
- Testing
- Low frequency magnetic therapy
- Volunteers
- 48 people
- Sponsor
- King Fahad Armed Forces Hospital
Flat Foot; Rigid, Flat Foot; Spastic
Joint Preserving Surgery for Correction of Spasmodic Flat- Foot in Skeletally Mature Foot
the investigators want to obtain a functional and radiological outcome of peroneus brevis, tertius and extensor digitorum longus muscles lengthening together with calcaneal osteotomies in the treatment of the spasmodic flat- foot.
- Trial name
- NCT03880318
- Testing
- Joint Preserving Surgery in spasmodic flat foot
- Volunteers
- 22 people
- Sponsor
- Assiut University
Gait, Spastic, Reliability
Reliability of Newly-acquired Gait in Toddlers With a Typical Development and a Unilateral Cerebral Palsy
gait reliability study of toddlers with typically developing and with unilateral cerebral palsy during the first 6 months of independent walking
- Trial name
- ReliabBB-AQM (NCT04559776)
- Testing
- gait analysis
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Clinical Center for Neuropsychomotor Recovery for Children Dr. Nicolae Robanescu
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Spastic Cerebral Palsy
Mollii - Personalized Suit for Treatment of Spasticity, GFMCS 3-5
The objective of this study was to examine the effect on spasticity and function of multifocal transcutaneous electrical stimulation incorporated in a 2-piece (Mollii) suit.
- Trial name
- NCT04322825
- Testing
- TENS incorporated into the Mollii suit
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Hvidovre University Hospital