Clinical trials: Spasticity, Muscle
Cerebral Palsy (CP)
Effects of Barefoot vs. Shod Whole Body Vibration Training in Children With Cerebral Palsy
Cerebral palsy (CP) refers to a group of lifelong conditions that affect the development of movement and coordination that lead to activity limitations due to damage to the developing fetal or neonatal brain tissue.
- Trial name
- NCT06596525
- Testing
- Conventional physical therapy, Barefoot Whole Body Vibration Training (WBVTb), Shod Whole Body Vibration Training (WBVTs)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Trakya University
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
Spastic Cerebral Palsy, Dysarthria
Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy
Lateral cord stimulation (LCS) was discovered by the author as the producer of an average threshold increase for abnormal muscle contraction responses, in experimental pathological conditions, as described and referred.
- Trial name
- NCT03676439
- Testing
- Magnetic Spinal Stimulation
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Sociedad Argenttina de Neuromodulación
Spastic Cerebral Palsy (sCP)
Talocrural Mobilization With Movement in Spastic Cerebral Palsy
The aim of this randomized controlled trial is to find the effect of Mulligan's Mobilization with Movement of Talocrural joint in Cerebral Palsy Patients having spasticity on improving Ankle Range of Motion, improving balance and…
- Trial name
- NCT06598657
- Testing
- Mobilization with Movement MWM, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Cerebral Palsy, Spastic
The Effects of Balance and Respiratory Muscle Training on Functional Capacity, Balance, Respiratory Function and Respiratory Muscle Strength in Children With Cerebral Palsy
Cerebral palsy (CP) is a permanent, non-progressive disorder in which the immature brain is affected by various causes in the prenatal, perinatal or postnatal period.
- Trial name
- NCT03396289
- Testing
- Conventional physiotherapy including balance exercises, Inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Spasticity, Cerebral Palsy
Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity
Oral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children.
- Trial name
- Best PK/PD (NCT00607542)
- Testing
- baclofen
- Where
- 11 sites in United States
- Volunteers
- 61 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spasticity, Muscle
Study of Brain-spinal Cord Neural Connectivity in Spasticity
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity.
- Trial name
- MOVE (NCT06281223)
- Testing
- intraoperative neuroelectrophysiological monitoring
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral Palsy, Spastic
The Efficacy of Derotation Banding on Outcome Measures in Children With Cerebral Palsy
The aim of the study is to compare the conventional rehabilitation program and derotation taping applied with Kinesio Tex tape in addition to conventional rehabilitation in children with hemiplegic or monoplegic cerebral palsy…
- Trial name
- NCT05251519
- Testing
- Kinesio Taping, Conventional Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Muğla Sıtkı Koçman University
Neurodevelopmental Disorders, Cerebral Palsy
Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
The purpose of this study is to determine the effects of Central Nervous System Stimulants, represented by Methylphenidate and Modafinil, compared to placebo control on motor performance in children with Cerebral Palsy.
- Trial name
- CP (NCT05675098)
- Testing
- Methylphenidate, Modafinil
- Where
- Kuwait
- Volunteers
- 30 people
- Sponsor
- Kuwait University
Cerebral Palsy (CP), Unilateral Cerebral Palsy
tDCS and Bi-manual Training in Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function.
- Conditions
- Cerebral Palsy (CP), Unilateral Cerebral Palsy, Spastic Cerebral Palsy (sCP)
- Trial name
- NCT07573865
- Testing
- Anodal tDCS
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
Cerebral Palsy
Effects of Treadmill Training on Motor Function, Balance, and Spasticity Reduction in Children With Cerebral Palsy
This study investigates the impact of treadmill training on motor function, balance, and spasticity reduction in children with cerebral palsy (CP).
- Trial name
- NCT06463301
- Testing
- Treadmill Training In CP child, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Cerebral Palsy
Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles
The aim of the study is to confirm the functional improvement obtained through treatment of spasticity on 2 agonist and antagonist muscles.
- Trial name
- NCT00133861
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Spastic Cerebral Palsy
Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy
We propose to identify patients and families for inclusion in pilot studies of the three modalities. Patients and their families will be asked to participate in these studies.
- Trial name
- NCT00011024
- Testing
- Self Hypnosis, Acupuncture, Osteopathic Manipulation
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Cerebral Palsy (CP), Unilateral Spastic Cerebral Palsy
Short-Term Effects of Manual Therapy Prior to Neuromotor Therapy in Children With Cerebral Palsy
This pilot study aims to evaluate the immediate, short-term biomechanical and neuromuscular effects of lower limb manual therapy applied as a preparatory phase prior to functional neuromotor rehabilitation in children with…
- Conditions
- Cerebral Palsy (CP), Unilateral Spastic Cerebral Palsy, Bilateral Spastic Cerebral Palsy, Diplegic Cerebral Palsy With Spasticity
- Trial name
- NCT07902466
- Testing
- Manual Therapy (T1 & T3)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- LIFE - Research and Care Institute - Santa Lucia IRCCS
Muscle Tone Abnormalities, Rigidity, Muscle
Neurophysiological Evaluation of Muscle Tone
The primary objective of this study is to apply a biomechanical system (the NeuroFlexor) associated with the EMG recording to study the physiological mechanisms that contribute to the regulation of muscle tone in healthy subjects…
- Conditions
- Muscle Tone Abnormalities, Rigidity, Muscle, Spasticity, Muscle
- Trial name
- NCT05070780
- Testing
- Robot-assisted examination
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Cerebral Palsy, Congenital
CIMT and BIMT Affect Functional Outcome in CP
The aim of this randomized controlled trial is to determine the effects of constraint induced movement therapy CIMT and BIM bimanual activities on functional outcome in hemiplegic CP.
- Trial name
- NCT04211623
- Testing
- Constraint induced movement therapy, Bimanual activities
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Cerebral Palsy, Cerebral Palsy, Spastic
Photo Biostimulation and Spasticity in Cerebral Palsy
the current study will address the spasticity in calf muscle secondary to cerebral palsy in children. As the spasticity can inversely affect muscle contraction, joint function, and consequently the function and quality of life…
- Trial name
- NCT05912959
- Testing
- photo biostimulation
- Where
- Saudi Arabia
- Volunteers
- 54 people
- Sponsor
- University of Hail
Spasticity Due to Cerebral Palsy
Phase 1b Study of Tizanidine in Pediatric Patients With Cerebral Palsy
A Single-Dose, Phase 1b, Multicenter, Open-Label Study to Assess the Pharmacokinetics, Safety and Tolerability, and Pharmacodynamics of Tizanidine at 4 Different Oral Dose Levels in Pediatric Subjects 2 to 16 Years Old With Mild…
- Trial name
- NCT01405950
- Testing
- Zanaflex Capsules
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Acorda Therapeutics
Spastic Diplegic Cerebral Palsy
Does Reducing Spasticity Permit an Increase in Strength?
Reduction of spasticity has been a major focus of the treatment of childhood cerebral palsy, resulting in numerous treatment strategies that target various parts of the motor system.
- Trial name
- NCT00255073
- Testing
- baclofen
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Spinal Cord Injury
Dose-Response Effects of Whole Body Vibration on Spasticity and Walking in SCI
This study will enroll people with SCI who have spasticity and some ability to walk. The goal is to understand if standing on a platform and receiving WBV results in decreased spasticity and improved walking ability.
- Trial name
- WBV (NCT02340910)
- Testing
- Short Duration, Long Duration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Shepherd Center, Atlanta GA