Clinical trials: Spectrum
Autism, Autism Spectrum Disorder (ASD
Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder
In addition to the core symptoms, children and adolescents with Autism Spectrum Disorder (ASD) often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, and aggression.
- Conditions
- Autism, Autism Spectrum Disorder (ASD, Asperger's Disorder, Pervasive Developmental Disorder (PDD-NOS)
- Trial name
- NCT01631851
- Testing
- Cognitive-Behavioral Therapy (CBT) for Irritability
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Farber Disease, Farber's Disease
Farber Disease Natural History Study
The primary objective of this study is to establish the natural history of Farber disease (acid ceramidase deficiency) through the collection and analysis of retrospective and prospective data on patients diagnosed with Farber…
- Conditions
- Farber Disease, Farber's Disease, Farber Lipogranulomatosis, Acid Ceramidase Deficiency
- Trial name
- NCT03233841
- Where
- 15 sites in United States, Argentina and 7 more
- Volunteers
- 45 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Schizophrenia, Cognitive Impairment
From Brain Currents to Interpersonal Flow: Investigating the Social Processing Stream of Schizophrenia
The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia.
- Conditions
- Schizophrenia, Cognitive Impairment, Social Competence
- Trial name
- ecoval (NCT03543553)
- Testing
- This is not an intervention study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Autism Spectrum Disorder, Behavior Problem
The Family Check-Up in Autism Services
Many children and youth with autism spectrum disorder have high levels of emotional and behavioural problems. Parents play a powerful role in supporting their children's well-being.
- Conditions
- Autism Spectrum Disorder, Behavior Problem, Emotional Problem
- Trial name
- NCT05280613
- Testing
- Family Check-Up, Treatment as Usual
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- McMaster University
Schizophrenia, Micrognathia
The Relevance Between the microRNA-30e in Plasma and the Prognosis of Schizophrenia Patients
This study investigates the relationship of circulating microRNA-30e and schizophrenia, and shows the relevance of the aberrant microRNA-30e expression in plasma with the variation disease status.
- Trial name
- NCT03007303
- Testing
- Atypical Antipsychotic, atypical antipsychotic combined with MECT
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dalian Seventh People's Hospital
Psychotic Disorders, Psychosis
Semantic and Syntactic Computerized Analysis of Free Speech
Subtle speech disorganization could be predictive of a transition to schizophrenia of ultra-high-risk patients. The aim of our longitudinal multicenter cohort study is to identify specific linguistic markers of the psychotic…
- Conditions
- Psychotic Disorders, Psychosis, Schizophrenia and Related Disorders, Schizophrenia Prodromal
- Trial name
- ASESID (NCT03525054)
- Where
- 3 sites in France
- Volunteers
- 215 people
- Sponsor
- University Hospital, Brest
Autism, Asperger's Disorder
Mercury Chelation to Treat Autism
This study will examine whether DMSA, an oral chelating agent that removes mercury and other metals from the body, is beneficial for children with autism.
- Conditions
- Autism, Asperger's Disorder, Child Development Disorders, Pervasive
- Trial name
- NCT00376194
- Testing
- DMSA
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Autism Spectrum Disorder
A Rhythmic and Auditory Approach for Children With Autism Spectrum Disorders (ASD)
The aim of this study is to assess the effectiveness of a rhythmic auditory training program in improving language skills in children with Autism Spectrum Disorder (ASD) who have a language acquisition disorder.
- Trial name
- THETABOOST (NCT07303413)
- Testing
- EEG recording, Picture recognition test
- Volunteers
- 24 people
- Sponsor
- Institut Pasteur
Autism Spectrum Disorder, Executive Dysfunction
Transcranial Direct Current Stimulation in Children With Autism
Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who…
- Trial name
- tDCS (NCT07092280)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- New York State Institute for Basic Research
Autism, Autism Disorder
Using Virtual Reality to Improve Emotion Understanding in Children With Autism
Autism Spectrum Disorders (ASD) are neurodevelopmental conditions characterized by difficulties in social interaction, communication, and in understanding one's own and others' mental and emotional states.
- Trial name
- NCT07367256
- Testing
- Oculus intervention, Traditional intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Autism, Social Communication
Parent-implemented Social Communication Treatment in Autism
An accumulation of research evidence has pointed to parent-implemented communication intervention as effective in reducing the severity of social communication deficits in autistic preschoolers.
- Conditions
- Autism, Social Communication, Speech Therapy, Parenting
- Trial name
- NCT05635760
- Testing
- Group-based Parent-implemented Social Communication Training, Self-learning-based Parent-implemented Social Communication Training
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 112 people
- Sponsor
- Chinese University of Hong Kong
Autism Spectrum Disorder
An Exploratory Clinical Study of a Low-dose Buprenorphine Patch for the Treatment of Autism Spectrum Disorders
This study evaluates the safety and efficacy of low-dose buprenorphine in patients with ASD by using standard ASD symptom assessment methods (e.g., SRS-2 and ABC) as well as AI-assisted analyses utilizing exploratory gaze…
- Trial name
- NCT06772324
- Testing
- NORSPAN Buprenorphine Transdermal Patchs for Very-low dose group, NORSPAN Buprenorphine Transdermal Patchs for Lower dose group, NORSPAN Buprenorphine Transdermal Patchs for higher dose group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Sixth Hospital
Autism Spectrum Disorder
Effectiveness and Implementation of a Mental Health Intervention for ASD
The purpose of this study is to test the effectiveness of training community mental health therapists to deliver a mental health intervention for ASD ("AIM HI") and study the process of implementing AIM HI in community mental…
- Trial name
- AIM HI (NCT02416323)
- Testing
- AIM HI Training
- Where
- United States
- Volunteers
- 609 people
- Sponsor
- University of California, San Diego
Autistic Disorder
Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology
During a previous therapeutic trial, investigators showed that the bumetanide improved significantly autism. This trial showed that a therapeutic response was obtained in 75% of cases.
- Trial name
- BUMAUTEP (NCT02947880)
- Testing
- Bumetanide
- Where
- France
- Sponsor
- University Hospital, Limoges
Health Equity, Autism Spectrum Disorder
Autism Doula Program Evaluation
Background: Findings from a group level assessment with caregivers of Black children with autism revealed barriers to equitable care and services (e.g., a lack of cultural representation among their child's care team, caregiver…
- Trial name
- NCT06896942
- Testing
- Autism Doula, DDBP Family Navigation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Psychotic Disorders
Implementation of National Guidelines for Treatment of Psychoses
The study is a combined health services research study and a clinical patient outcomes sub-study. The aims of the study are to give new knowledge on (RQ1) current implementation in mental health services of four evidence based…
- Trial name
- NCT03271242
- Testing
- Systematic implementation support, No implementation support
- Volunteers
- 325 people
- Sponsor
- University Hospital, Akershus
Cutaneous Lymphoproliferative Diseases, Mycosis Fungoides of Skin (Diagnosis)
Development of an AI-Assisted Diagnostic Tool for Mycosis Fungoides and Other Cutaneous Lymphoproliferative Diseases Using Microscopic Image Analysis: A Training and Validation Study
Cutaneous lymphoproliferative diseases (CLPDs) are a group of skin disorders that range from benign conditions, such as pseudolymphomas, to malignant forms like cutaneous T-cell and B-cell lymphomas.
- Conditions
- Cutaneous Lymphoproliferative Diseases, Mycosis Fungoides of Skin (Diagnosis), T Cell Dyscrasia, PLEVA-PLC Spectrum
- Trial name
- NCT07705386
- Testing
- AI-assisted histopathology image analysis
- Where
- Egypt
- Volunteers
- 463 people
- Sponsor
- Cairo University
Neuromyelitis Optica Spectrum Disorder, Pregnancy Related
Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy
This is an observational study to monitor female participants exposed to UPLIZNA during pregnancy. This study requires voluntary reporting of pregnancies in female participants with NMOSD exposed to UPLIZNA during pregnancy or…
- Trial name
- NCT05909761
- Testing
- UPLIZNA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Amgen
Autism Spectrum Disorder
CPI Training for Parents of Children With ASD
The purpose of this 24-week study is to determine whether the "Parent-based Crisis Prevention Institute (CPI) physical management training program" (i.e., P-CPI) is effective in increasing self-efficacy in parents of children…
- Trial name
- NCT03537261
- Testing
- Parent-based Crisis Prevention Institute (CPI) physical management training program (P-CPI)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism, Food Allergies
An Autism Study Using Nambudripad's Food Allergy Elimination Treatments
1. We hypothesize that children in the experimental group will show a significant improvement over the control group as all food allergens groups and some other relevant allergenic substances are desensitized in a systematic way…
- Trial name
- NCT00247156
- Testing
- Acupressure treatments and NAET treatments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Nambudripad's Allergy Research Foundation
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