Clinical trials: Spinal Puncture
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Sepsis, Meningitis
Neonatal Comfort Seat Allowing Safe Lumbar Puncture and Minimizing Failure: a Randomized Controlled Trial
A research trial which compares standard of care against employing a novel device for immobilization of babies undergoing upright LP, the present working name for the device is LP Comfort Seat (LPCS).
- Trial name
- NeoCALM (NCT06811428)
- Testing
- A novel device for immobilization of babies undergoing upright LP, the present working name (non-proprietary) for the device is LP Comfort Seat (LPCS), Standard of Care (SOC)
- Volunteers
- 68 people
- Sponsor
- Joel Cox
Leukemia
Ultrasound Use for Difficult Lumbar Punctures in Pediatric Oncology Patients
Hematology-oncology patients may require frequent lumbar puncture for diagnosis, assessment and therapy. When LP is difficult, the patient may endure multiple attempts, prolonged anesthesia time, and with failure of LP may…
- Trial name
- NCT01643291
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Nationwide Children's Hospital
Labor Pain, Epidural Analgesia
Different Spinal Needles Sizes and Dural Puncture Epidural For Labor Analgesia
The rationale behind the dural puncture epidural (DPE) technique lies in the fact that a dural perforation with a spinal needle purportedly creates a conduit for accelerated translocation of local anesthetics from the epidural to…
- Trial name
- NCT03389945
- Testing
- 25G Dural Puncture Epidural Block, 27G Dural Puncture Epidural Block
- Where
- 2 sites in Chile
- Volunteers
- 140 people
- Sponsor
- University of Chile
Conscious Sedation, Simple Lacerations Less Than 4 cm
A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
The objective of this project is to compare the sedative effects of intranasal midazolam versus inhaled nitrous oxide (N2O) for minor procedures in the pediatric emergency department.
- Conditions
- Conscious Sedation, Simple Lacerations Less Than 4 cm, Lumbar Punctures, Minor Incision Drainage of Abscesses Not Requiring Extensive Debridement
- Trial name
- NCT03085563
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Colorado, Denver
Indication for Lumbar Puncture
The Effectiveness of a Pediatric Lumbar Puncture Restraint Device
This is a pilot study to evaluate a restraint device for lumbar punctures. Designed to help improve the restraint techniques for lumbar puncture, the restraint device will be compared to the current standard of manual physical…
- Trial name
- SNOWBOARD (NCT00980070)
- Testing
- Pediatric Restraint for Lumbar Puncture, Lumbar Puncture Device, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Leukemia, Non Hodgkin Lymphoma
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture
In this randomised controlled study the investigators intended to compare the analgesic effects of EMLA and\or nitrous oxide in children submitted to lumbar puncture.
- Trial name
- NCT00808171
- Testing
- Livopan, EMLA
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Spinal Puncture
Randomized Evaluation of a Positioning Pillow for Lumbar Puncture in Paediatric Hematology-Oncology
We have developed a positioning cushion for LP which allows the child to be relaxed in an adequate position, and to maintain this position throughout LP.
- Trial name
- NCT00775112
- Testing
- pillow
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- Centre Leon Berard
Fever
Ultrasound-Assisted Lumbar Puncture in Children
The aim of this study is to determine if emergency physician performed ultrasound-assisted lumbar puncture improves first-time success rates in a pediatric population.
- Trial name
- NCT03099642
- Testing
- ultrasound-assisted lumbar puncture
- Where
- Canada
- Volunteers
- 166 people
- Sponsor
- St. Justine's Hospital
Traumatic Lumbar Puncture
The Effect of Bedside Ultrasound Assistance on the Proportion of Successful Infant Spinal Taps
The reported rate of unsuccessful spinal taps in children, especially young infants, is high. Our hypothesis is that ultrasound assistance can improve the success rate of spinal taps.
- Trial name
- NCT02133066
- Testing
- Bedside Ultrasound-Assisted Site Marking, Mindray M7 Ultrasound, Routine lumbar puncture
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Spinal Puncture, Anesthesia
Anesthesia Lumbar Puncture In Children
The study is carried out in a prospectively randomly controlled way. In the context of acknowledgement and understanding from parents, by comparing with traditional process(no anesthesia), lidocaine surface anesthesia is randomly…
- Trial name
- ALPIC (NCT02590705)
- Testing
- Lidocaine
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Pediatric Lumbar Puncture
Intravenous Fluid Administration's Effect on Pediatric Lumbar Puncture
The purpose of this project is to determine if administration of normal saline intravenous fluids prior to a lumbar puncture improves first time success of lumbar puncture in infants less than 3 months of age.
- Trial name
- NCT05302765
- Testing
- Normal Saline Intravenous Fluids
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Alabama at Birmingham
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer
This phase I trial assesses the use of lumbar punctures to detect whether there is circulating tumor deoxyribonucleic acid (ctDNA) in the fluid that surrounds the brain and spinal cord (cerebrospinal fluid) in patients with stage…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06816979
- Testing
- Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
Meningitis, Pediatric Disorder
Bedside Ultrasound on the Effectiveness of Lumbar Puncture in Children.
The aim of the study is to assess the influence of ultrasound examination of the lumbar spinal canal on the effectiveness of lumbar puncture. An open-label, randomized interventional study.
- Trial name
- NCT06584864
- Testing
- bedside ultrasound examination of the lumbar spinal canal
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Warsaw
Leukemia, Lymphoma
Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma
The hypothesis of the study is that propofol-fentanyl sedation for lumbar punctures in children with acute leukemia/lymphoma results in fewer adverse events than propofol sedation alone.
- Trial name
- NCT00214370
- Testing
- Propofol-Fentanyl, Propofol alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Pediatric Lumbar Puncture
Identification of Cerebrospinal Fluid With Injeq IQ-Needle During Paediatric Lumbar Puncture
This is clinical feasibility study on the device performance with paediatric patients. The main objective is to validate the performance of investigational device in distinguishing and identifying the cerebrospinal fluid (CSF)…
- Trial name
- NCT02792660
- Testing
- Injeq IQ-Needle
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Injeq Ltd
Lumbar Disc Herniation, Percutaneous Endoscopic Lumbar Discectomy
Randomized Controlled Clinical Study of Biplanar Ultrasound-guided Puncture of Lumbar Interforamen
The goal of this clinical trial is to compare Xplane ultrasound with radiography for guidance of lumbar interforamen puncture in patients with lumbar disc herniation.
- Conditions
- Lumbar Disc Herniation, Percutaneous Endoscopic Lumbar Discectomy, Three-dimension Ultrasound, Learning Curves
- Trial name
- NCT06315803
- Testing
- Real-time 3D Xplane ultrasound
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Yi Mao
Febrile Convulsions
The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion
The actual recommendations for infants aged 3 to 12 months presented with first episode of Febrile Convulsions highly recommend performing lumbar puncture in order to rule out Bacterial Meningitis.
- Trial name
- NCT01443611
- Where
- Israel
- Volunteers
- 122 people
- Sponsor
- HaEmek Medical Center, Israel
Neonate, Meningitis
Repeat Lumbar Puncture at 24 Versus 48 Hours After Traumatic Lumbar Puncture in Neonates
Visibly traumatic as well as microtraumatic lumbar punctures (LP) are very common in the neonatal period. The presence of blood makes it difficult to interpret cerebro-spinal fluid (CSF) findings.
- Conditions
- Neonate, Meningitis, Spinal Puncture
- Trial name
- NCT04794881
- Testing
- 24 hours, 48 hours
- Where
- India
- Volunteers
- 42 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh