Clinical trials: Spine Deformity
Tethered Cord, Chiari I Malformation
Magnetic Resonance Imaging of the Spine
Diffusion-weighted (DW) magnetic resonance imaging (MRI) imaging is a well established method for detecting acute injury to the brain and is used on all children undergoing an MRI brain scan at Children's Healthcare of Atlanta.
- Trial name
- MRIS (NCT01382290)
- Testing
- MRI
- Where
- United States
- Sponsor
- Children's Healthcare of Atlanta
Headache, Tumor
Dexmedetomidine and Propofol for Pediatric MRI Sedation
The purpose of this study is to compare the results of combining two anesthetic medications (dexmedetomidine and propofol) in low doses with a standard dose of a single drug that is commonly used to provide sedation/anesthesia…
- Conditions
- Headache, Tumor, Seizure Disorder, Neurofibromatoses
- Trial name
- NCT03513757
- Testing
- propofol, Dexmedetomidine, Glycopyrrolate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Plagiocephaly
Postural Assessment in Plagiocephaly
The positional plagiocephaly is a condition involving craniofacial asymmetry. The purpose of this study is to evaluate the spine, the posture and the psychomotor state in children who were diagnosed with infant plagiocephaly.
- Trial name
- NCT01989286
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Spine Deformity, Scoliosis
The Effect of Three-dimensional Exercise (Schroth Exercise) on Diaphragm Thickness in Adolescent Idiopathic Scoliosis Patients
Spinal deformity is common in childhood and adolescence, and can often present as scoliosis or increased thoracic kyphosis deformity with various etiologies.The diaphragm is the main respiratory muscle, and diaphragm contraction…
- Conditions
- Spine Deformity, Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence
- Trial name
- NCT06417944
- Testing
- Scoliosis study form, Scoliosis X-ray (orthorontgenogram), Pulmonary function test
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Adolescent Idiopathic Scoliosis, Brace
Effect of Spinal Manipulative Therapy Combined with Brace in Moderate-severe Grade Adolescent Idiopathic Scoliosis: a Randomized Controlled Trial
Objective: To determine whether spinal manipulative therapy combined with brace is superior to a control of brace alone in improving spinal deformity and quality of life of moderate-severe grade AIS.
- Conditions
- Adolescent Idiopathic Scoliosis, Brace, Spinal Manipulative Therapy
- Trial name
- NCT06648005
- Testing
- the spinal manipulative therapy combined brace, brace
- Where
- China
- Volunteers
- 169 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Idiopathic Scoliosis
Analysis of Body Balance Parameters in Children With Idiopathic Scoliosis
The aim of the study is to compare body balance parameters assessed using the AMTI dynamometric platform in children with idiopathic scoliosis (with and without Schroth therapy) compared to control group.
- Trial name
- NCT06290843
- Testing
- Schroth method
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Central Core Disease, Centronuclear Myopathy
Molecular and Genetic Studies of Congenital Myopathies
In the Congenital Myopathy Research Program at Boston Children's Hospital and Harvard Medical School, the researchers are studying the congenital myopathies (neuromuscular diseases present from birth), including central core…
- Conditions
- Central Core Disease, Centronuclear Myopathy, Congenital Fiber Type Disproportion, Multiminicore Disease
- Trial name
- NCT00272883
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Boston Children's Hospital
Adolescent Idiopathic Scoliosis (AIS)
Clinical and Biological Parameters in Adolescent Idiopathic Scoliosis
This single-center, observational, cross-sectional study aims to investigate the association between fecal calprotectin levels and clinical characteristics in adolescents with idiopathic scoliosis.
- Trial name
- NCT07900126
- Volunteers
- 83 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Adherence, Treatment, Spinal Deformity
Adherence to Physiotherapy Scoliosis Specific Exercises in Adolescents With Spine Deformity: Development of a New Questionnaire
This study aims to develop a new instrument capable of providing an efficient measure of the quality and quantity of adherence to Physiotherapy Scoliosis Specific Exercises performed at home by growing patients with spinal…
- Trial name
- NCT05433545
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Spinal Deformity
Pedicle Screw Positioning With MySpine vs Free Hand Technique
Randomized clinical study in order to evaluate the accuracy of pedicle screw positioning during spine surgery performed with MySpine patient match positioning guide or Free hand technique.
- Trial name
- NCT03369158
- Testing
- patient specific pedicle screw positioning guide, Free hand technique pedicle screw positioning, MUST pedicle screw
- Volunteers
- 29 people
- Sponsor
- Medacta International SA
Wounds
The Use of Dermabond Versus Standard Staple for Wound Closure in Children With Neuromuscular Scoliosis Undergoing Spinal Deformity Correction Surgery
This is a prospective, Phase II (hypothesis generating) randomized pilot study investigating the efficacy of using Dermabond as a method of final wound closure as compared to the standard staple method in children with…
- Trial name
- NCT01135940
- Testing
- 2-octylcyanoacrylate (Dermabond) closure, Standard staple closure
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Early-Onset Scoliosis Deformity of Spine
Long-Term Follow-Up Of Surgical Management Of Early Onset Scoliosis Using Growing Rods
The aim of this work is to evaluate the long-term outcome of the graduates (those who completed the gradual lengthening procedures), to better understand the full scope and natural course of Growing Rods treatment for EOS and to…
- Trial name
- NCT04945343
- Testing
- Growing Rods
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Paralytic Scoliosis, Pelvic Obliquity
Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury
This randomized controlled trial compares posterior minimally invasive correction surgery with conventional posterior spinal fusion for children with paralytic scoliosis and severe pelvic obliquity following spinal cord injury.
- Conditions
- Paralytic Scoliosis, Pelvic Obliquity, Spinal Cord Injury, Neuromuscular Scoliosis
- Trial name
- NCT07594574
- Testing
- Posterior Minimally Invasive Correction Surgery, Conventional Posterior Spinal Fusion
- Where
- China
- Volunteers
- 39 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Spine Deformities, Idiopathic Scoliosis
Blood Propofol Concentrations in Children During Spinal Surgery
During major spinal surgery evoked potential monitoring is performed to detect spinal cord damage. Intra-venous anaesthesia is the preferred anaesthetic technique because volatile anaesthetic agents supress the evoked potentials.
- Conditions
- Spine Deformities, Idiopathic Scoliosis, Neuromuscular Dystrophy
- Trial name
- NCT01932424
- Testing
- Pelorus 1500, Propofol 2% (Diprivan 2%, Astra Zeneca UK)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Scoliosis, Adolescent Idiopathic Scoliosis (AIS)
Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis
Adolescent Idiopathic scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT02285621
- Testing
- Optimized brace versus conventional Boston brace
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital
Scoliosis, Vitamin D
6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation
The study aimed to: 1. To investigate and compare the changes in bone mineral density (BMD), trabecular bone micro-architecture, bone strength, and curve severity at a mean of 6 years longitudinal follow up in AIS girls with low…
- Conditions
- Scoliosis, Vitamin D, Bone
- Trial name
- NCT02904421
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Hyperkyphosis, Spine Deformity
Ultrasonographic Measurement of Diaphragmatic Thickness in Adolescents With Thoracal Hyperkyphosis
Spinal deformity is common in childhood and adolescence. Any spinal deformity, especially one that affects the thoracic spine, can affect lung function.The diaphragm is the main respiratory muscle, and diaphragm contraction is…
- Conditions
- Hyperkyphosis, Spine Deformity, Diaphragm Issues
- Trial name
- NCT06418334
- Testing
- Thoracal hyperkyphosis study form, Scoliosis graphy, Pulmonary function test
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Scoliosis, Adolescent Idiopathic Scoliosis
Validation of a New Generation of Orthopedic Brace for Treating Adolescent Idiopathic Scoliosis by Using Growth Modulation
Adolescent Idiopathic Scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT04889339
- Testing
- Test brace versus control brace: Immediate correction, Test brace versus control brace: Long-term correction
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- St. Justine's Hospital
Early-Onset Scoliosis Deformity of Spine
Serum and Urine Titanium Levels in Children With Early Onset Scoliosis Treated With Growth-Sparing Instrumentation
The investigators are conducting research to compare serum and urine titanium levels in children with early onset scoliosis who are being treated with certain types of metal spinal rods.
- Trial name
- NCT04069637
- Testing
- Growth-sparing instrumentation and titanium levels
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Idiopathic Spinal Deformities
Muscle Energy Technique Versus Myofacial Release in Adolescents With Spinal Deformity
Spinal deformity may not only alter the physical appearance, but may also have a psychological impact on the child, particularly in the adolescent to whom self- image is so important.
- Trial name
- NCT05120089
- Testing
- muscle energy technique and myofacial release (physiotherapy techniques)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology