Clinical trials: Spine Deformity
Juvenile and Adolescent Idiopathic Scoliosis
3-D Correction of Adolescent Idiopathic Scoliosis (AIS) With Differential Metals
This study is designed to evaluate the coronal, sagittal, and axial correction of deformity secondary to adolescent idiopathic scoliosis utilizing a technique employing a posterior spinal fusion construct utilizing rods of…
- Trial name
- AIS (NCT05631821)
- Testing
- differential rod bending with rod contours (MESA Spinal System)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Scoliosis, Kyphosis
Postoperative and Chronic Pain Genetic Spine and Pectus Surgery Study
This will be an open label, prospective study to determine the association between specific genotypes, epigenetics and behavioral factors, with the phenotypes, defined by pain perception, postoperative pain, analgesic and side…
- Conditions
- Scoliosis, Kyphosis, Kyphoscoliosis, Pectus Excavatum
- Trial name
- NCT02998138
- Where
- 5 sites in United States
- Volunteers
- 880 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Proximal Junctional Kyphosis, Adult Spinal Deformity Surgery
Post-Operative Thoracolumosacral Orthosis for PJK
Proximal junctional kyphosis (PJK) is a common post-operative radiographic finding after surgery for adult spinal deformity (ASD) patients.
- Conditions
- Proximal Junctional Kyphosis, Adult Spinal Deformity Surgery, Thoracolumbosacral Orthosis
- Trial name
- NCT06491030
- Testing
- Align PJK™ TLSO brace, Standard of Care
- Where
- 6 sites in United States
- Volunteers
- 84 people
- Sponsor
- Hospital for Special Surgery, New York
Spondylolisthesis
Posterior Lateral Fusion (PLF) With Dynesys
The primary purpose of this study is to track and document the clinical outcomes of patients with radicular pathology following posterior lateral fusion with the Dynesys Spinal System.
- Trial name
- NCT00791180
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Zimmer Biomet
Spinal Muscular Atrophy, Spine Deformity
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).
- Conditions
- Spinal Muscular Atrophy, Spine Deformity, Scoliosis
- Trial name
- PIERRE (NCT05866419)
- Testing
- ThecaFlex DRx System
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- Alcyone Therapeutics, Inc
Paralytic Scoliosis, Pelvic Obliquity
Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury
This randomized controlled trial compares posterior minimally invasive correction surgery with conventional posterior spinal fusion for children with paralytic scoliosis and severe pelvic obliquity following spinal cord injury.
- Conditions
- Paralytic Scoliosis, Pelvic Obliquity, Spinal Cord Injury, Neuromuscular Scoliosis
- Trial name
- NCT07594574
- Testing
- Posterior Minimally Invasive Correction Surgery, Conventional Posterior Spinal Fusion
- Where
- China
- Volunteers
- 39 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Postoperative Bracing for Spinal Deformity
Utility of Postoperative Bracing
The study is being done to assess if the use of bracing helps improve quality of life of patients that are undergoing a spinal fusion for deformity.
- Trial name
- NCT03947541
- Testing
- Thoracolumbosacral (TLSO) brace, No Bracing
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Spine Deformity, Adult Scoliosis
The Effect of Peloidotherapy in Young Adults Undergoing Physical Therapy Scoliosis Specific Exercises (PSSE)
Scoliosis is a musculoskeletal disorder defined by a three-dimensional spinal deformity that can result in substantial clinical and functional limitations, particularly during adolescence and young adulthood.
- Conditions
- Spine Deformity, Adult Scoliosis, Peloidotherapy
- Trial name
- NCT07459400
- Testing
- Adult Scoliosis Study Form, Scoliosis graphy, Visuel Aanalog Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Hyperkyphosis, Adolescent
Basic Body Awareness Therapy (BBAT) and Corrective Exercise for Adolescent Hyperkyphosis
This study is designed as a randomized controlled trial to evaluate the additional benefits of Basic Body Awareness Therapy (BBAT) when combined with a corrective exercise program for adolescents with postural hyperkyphosis.
- Trial name
- NCT07598591
- Testing
- Corrective Exercise and Basic Body Awareness Therapy (BBAT), Corrective Exercise and Autogenic Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Plagiocephaly
Postural Assessment in Plagiocephaly
The positional plagiocephaly is a condition involving craniofacial asymmetry. The purpose of this study is to evaluate the spine, the posture and the psychomotor state in children who were diagnosed with infant plagiocephaly.
- Trial name
- NCT01989286
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Degenerative Disc Disease, Spondylolisthesis
Quintex® Follow-up After One Year Minimum
Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Trauma, Spinal Stenosis
- Trial name
- Quintex (NCT04489394)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Scoliosis, Kyphosis
How Often and What Type of Deformity is Detected in All Spine Radiographs?
The study will be done retrospectively.The aim of this study is to retrospectively examine the spinal pathologies of patients with a prediagnosis of spinal deformity and for whom spinal radiography is requested and to evaluate…
- Conditions
- Scoliosis, Kyphosis, Radiography
- Trial name
- NCT06369883
- Testing
- Spine radiography
- Volunteers
- 632 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Degenerative Disc Disease, Degenerative Scoliosis
Clinical Outcome Measure at Stryker Spine
This is a multicenter, prospective, retrospective, Post Market Clinical Follow-up (PMCF) study in subjects who have undergone or will undergo surgery utilizing one or more Stryker devices according to Stryker cleared Instructions…
- Trial name
- COMPASS (NCT06226272)
- Testing
- Spinal Fusion, Spinal Deformities Correction
- Where
- 7 sites in United States
- Volunteers
- 5,222 people
- Sponsor
- VB Spine, LLC
Kyphoscoliosis
Indication and Treatment of Adult Kyphoscoliosis
Degeneration, iatrogenic-/idiopathic causes and fractures can lead to kypho- scoliotic deformities potentially resulting in pain and loss of function.
- Trial name
- INTRAKS (NCT04536909)
- Testing
- Non-surgical, Surgical
- Where
- 5 sites in Japan, Norway and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Hospital Costs
Variability in ASD (Adult Spinal Deformity) Value
The study will examine if variability in created value (outcome/costs) over the care cycle for ASD patients can be explained by patient and treatment characteristics.
- Trial name
- VIAV (NCT04638894)
- Testing
- Surgical treatment of patients with adult spinal deformity
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Perioperative Anemia, Surgery
The Effects of Ferric Derisomaltose on Postoperative Anemia in Spinal Deformity Surgery
The prognosis of patients undergoing spinal deformity surgery is often compromised by perioperative anemia due to iron deficiency.
- Conditions
- Perioperative Anemia, Surgery, Spinal Deformity, Adult
- Trial name
- NCT05714007
- Testing
- Ferric derisomaltose, Ferrous succinate
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Flexible Flatfoot, Lumbar Spine Injury
Relationship Between Flexible Flat Foot and Lumbar Proprioception
The purpose of this study was to determine the relationship between flexible flatfoot and lumbar proprioception.
- Conditions
- Flexible Flatfoot, Lumbar Spine Injury, Proprioceptive Disorders
- Trial name
- NCT06879756
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Cairo University
Scoliosis, Scoliosis Kyphosis
Effect of Adult Spinal Deformity Surgery on Functional Reach
Adult spinal deformity (ASD) is a common spinal condition that often impacts an individual's ability to stand and maintain an upright posture.
- Trial name
- NCT06258161
- Testing
- Spinal Fusion, No intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Knowledge Acquisition, Engagements and Motivation
Is Microlearning the Alternative in the Age of Hyperconnectivity
This Quasi-Experimental Study evaluated whether microlearning a strategy delivering brief, focused learning units enhances knowledge acquisition and retention among fifth-year medical students studying pediatric spinal…
- Trial name
- NCT06926114
- Testing
- Microlearning intervention, Traditional block-format module group
- Where
- Tunisia
- Volunteers
- 24 people
- Sponsor
- Faculty of Medicine, Sousse