Clinical trials: Spontaneous Breathing Trial
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
ARDS (Acute Respiratory Distress Syndrome)
International Survey for EXTubation Evaluation and Respiratory Dynamics in Acute Respiratory Distress Syndrome
EXTEND ARDS study is an international survey for ventilator weaning and extubation among ARDS patients. This study will be conducted on behalf of the Japanese ARDS Clinical Practice Guideline 2024 Committee as well as endorsement…
- Trial name
- EXTEND ARDS (NCT06598709)
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Hiroshima University
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial, Ventilator Weaning
Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
- Trial name
- NCT00911378
- Testing
- Pressure support ventilation, Spontaneous breathing trials
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Ventilator Weaning, Child
The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning
To correlate the data obtained by Electrical impedance tomography (EIT) during the spontaneous breathing trials (SBT) on a T-piece, in children, with failure in the trial and Extubation failure.
- Conditions
- Ventilator Weaning, Child, Spontaneous Breathing Trial, Electrical Impedance Tomography
- Trial name
- NCT04011852
- Testing
- Electrical Impedance tomography
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo General Hospital
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Stability During Surgical Operation, Complication, Postoperative
Clinical Trial of Thoracoscopic Bullectomy Surgery Under Spontaneous Ventilating Anesthesia
With the development of video-assisted thoracoscopic surgery (VATS) techniques and technology for anesthesia control, non-intubated anesthesia with spontaneous ventilation has been widely applied in VATS.
- Conditions
- Stability During Surgical Operation, Complication, Postoperative, Postoperative Hospitalization Time
- Trial name
- NCT03016858
- Testing
- Thoracoscopic Bullectomy Surgery
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Infant, Newborn, Diseases, Airway Morbidity
Integrated Prediction of Extubation Outcome by the Spontaneous Breathing Trial in Newborn Infants
Prolonged mechanical ventilation (MV) is associated with significant adverse effects in newborn infants and clinicians aim at its minimum possible duration.
- Trial name
- NCT03956511
- Testing
- Spontaneous Breathing Trial
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- Ourania Kaltsogianni
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial
A SBT-based Protocol-directed Program in Difficult-to-Wean Patients
Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with…
- Trial name
- NCT05035355
- Testing
- a weaning protocol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- JinyanXing
Atelectasis, Hypoxemia
Pulmonary Ultrasound for the Assessment of Atelectasis in Anesthetized Children Using a Laryngeal Mask Airway.
This study will use lung ultrasounds (LUS) to evaluate the incidence and severity of intraoperative atelectasis in anesthetized children undergoing minor surgery using a laryngeal mask airway.
- Trial name
- NCT06214312
- Testing
- Lung Ultrasounds
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Premature
dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure.
- Trial name
- NCT05865977
- Testing
- diaphragmatic tissue Doppler imaging，dTDI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wang Jianhui
Respiratory Distress Syndrome
Extubation Readiness Study in Very Low Birthweight Infants
The objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (VLBW) infants who are intubated for >48 hours and have not yet been…
- Trial name
- NCT01471431
- Testing
- spontaneous breathing trial
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- University of Pennsylvania
Respiratory Distress Syndrome, Newborn, Ventilator-associated Lung Injury
Positioning During SBT in NICU Infants
Mechanical ventilation is a life-sustaining intervention in premature infants with respiratory difficulties. There is relative consensus when to intubate and provide positive pressure mechanical ventilation in the presence of…
- Trial name
- NCT02835209
- Testing
- Work of breathing during SBT
- Sponsor
- Christiana Care Health Services