Clinical trials: Spontaneous Breathing Trial
Mechanical Ventilation Weaning, Spontaneous Breathing Trial
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial…
- Conditions
- Mechanical Ventilation Weaning, Spontaneous Breathing Trial, High Flow Oxygen Therapy
- Trial name
- HFTO-SBT (NCT07864415)
- Testing
- T-piece, HFTO 50, washout, HFTO 70, washout, PSV., T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
- Volunteers
- 30 people
- Sponsor
- Argentinian Intensive Care Society
Critically Ill
Microcirculation in Spontaneous Breathing Trial
Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients.
- Trial name
- NCT04711590
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- National Taiwan University Hospital
Respiratory Failure, Tracheostomy Complication
Ventilation Weaning Strategies and Correlation to Outcomes in Tracheostomized Patients in the Lausanne ICU
This retrospective study aims to study characteristics of patients tracheotomized in the Lausanne ICU, both overall and by primary reasons of intubation.
- Trial name
- NCT04987398
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Piquilloud Imboden Lise
Weaning, Mechanical Ventilation
Effect of High Flow Oxygen Therapy in Spontaneous Breathing Trial on Weaning in Mechanical Ventilated Patients
This clinical trial is aimed to show a spontaneous breathing trial using high flow oxygen therapy may lower weaning failure rate and reintubation rate than using T-piece.
- Conditions
- Weaning, Mechanical Ventilation, Extubation
- Trial name
- HOST (NCT03929328)
- Testing
- High flow oxygen therapy in spontaneous breathing trial
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Sang-Min Lee
Post-cardiac Surgery, Ventilator Weaning
Correlation Analysis Between Mostcare Parameters and Spontaneous Breathing Trial in Patients After Cardiac Surgery
Cardiac output (CO) monitoring is of primary importance in high-risk surgery and critically ill patients. Intermittent thermodilution (ThD) by means of a pulmonary artery catheter (PAC) was invasiveness, the occurrence of…
- Trial name
- NCT06230497
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Anesthesia
Preoxygenation With Positive Inspiratory Pressure During Induction of Anesthesia
Adults patients scheduled for elective surgery were randomly allocated to receive preoxygenation with spontaneous breathing, positive pressure ventilation (positive inspiratory pressure: 12 cmH2O) without PEEP, and with PEEP…
- Trial name
- PREOX (NCT02313766)
- Testing
- PPV : positive pressure ventilation, PEEP : PPV + PEEP
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Respiratory Failure
Extubation With or Without Spontaneous Breathing Trial
Spontaneous breathing trial (SBT) has long been thought to be a essential process before extubation. In this study,the investigator hypothesized that SBT could be not essential during weaning from ventilator and investigated…
- Trial name
- SBT (NCT01020773)
- Testing
- spontaneous breathing trial
- Volunteers
- 67 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Respiratory Distress Syndrome
Extubation Readiness Study in Very Low Birthweight Infants
The objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (VLBW) infants who are intubated for >48 hours and have not yet been…
- Trial name
- NCT01471431
- Testing
- spontaneous breathing trial
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- University of Pennsylvania
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (SARS-Cov-2) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- NoCovid (NCT04305457)
- Testing
- Nitric Oxide
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Reverse Triggering, Patient Ventilator Dyssynchrony
Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation
The goal of this study is to identify patients with reverse triggering who's the potential to breath spontaneously is hidden because of the ventilator management strategy by performing a simple 30sec-test with includes reducing…
- Trial name
- INTRINSIC (NCT06445049)
- Testing
- brief test
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiration, Artificial
A SBT-based Protocol-directed Program in Difficult-to-Wean Patients
Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with…
- Trial name
- NCT05035355
- Testing
- a weaning protocol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- JinyanXing
Weaning Mode Comparison
PAV vs Assist Control After Failed SBT
The primary aim of this research is to determine the feasibility of conducting a randomized controlled trial comparing two ventilation modes in patients admitted to the ICU who require mechanical ventilation.
- Trial name
- NCT02773433
- Testing
- Proportional Assist Ventilation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning
Detecting Early Weaning-induced Pulmonary Oedema Using Lung Impedance Negative Trend During SBT
Critically ill patients who require a breathing machine are routinely assessed with a spontaneous breathing trial (SBT) to determine if they can safely breathe on their own.
- Conditions
- Weaning-induced Pulmonary Edema, Mechanical Ventilation Weaning, Spontaneous Breathing Trial
- Trial name
- DEWPOINT (NCT07886671)
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Ventilator Weaning
Spontaneous Breathing Trial With T-piece or Inspiratory Pressure Augmentation
Weaning is an important process to gradually separate mechanically ventilated patients from ventilators. A good weaning strategy aims to early identify mechanically ventilated patients who are ready for extubation but not to…
- Trial name
- SBT-TIP (NCT04222205)
- Testing
- Spontaneous breathing trial (SBT) crossover sequence 1, Spontaneous breathing trial (SBT) crossover sequence 2
- Where
- 3 sites in Taiwan
- Volunteers
- 2,143 people
- Sponsor
- National Taiwan University Hospital
Muscle Weakness, Weaning Failure
Abdominal Muscle Thickness in Mechanically Ventilated Patients
The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated…
- Trial name
- NCT03567564
- Testing
- Abdominal muscles ultrasound
- Where
- 2 sites in Canada, Italy
- Volunteers
- 35 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Obesity, Respiratory Failure
Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient
The decision to extubate a patient after acute respiratory failure is based on clinical observation and measurement of pulmonary mechanics. Current extubation criteria(tidal volume, respiratory frequency...) lack of specificity.
- Conditions
- Obesity, Respiratory Failure, PSV 7cmH2O PEEP 7cmH2O, PSV 7 cmH2O PEEP 0 cmH20
- Trial name
- NCT01616901
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation Complication, Acute Respiratory Failure
Non-invasive Respiratory Monitoring During SBT
Spontaneous breathing trials (SBTs) assess readiness for extubation, yet the use of conventional parameters used to establish weaning success may be elusive, especially in high-risk patients.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Re-intubation Rate
- Trial name
- NCT05295186
- Where
- 2 sites in Italy
- Volunteers
- 238 people
- Sponsor
- University of Bari