Clinical trials: Step
Asthma
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe.
- Trial name
- AIM4:Next Step (NCT06572228)
- Testing
- dupilumab, ICS/LABA
- Where
- 77 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
Type 1 Diabetes Mellitus, Physical Activity
Physical Activity in Children With Type 1 Diabetes Study
This study aims to test the feasibility of a physical activity intervention called the Steps To Active Kids (STAK) programme in children aged 9 - 11 years with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT02144337
- Testing
- Steps To Active Kids (STAK) programme
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Nottingham
Rhabdomyosarcoma, Non-Rhabdo. Soft Tissue Sarcoma
Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas
This study will test the feasibility of using novel/existing imaging technologies focused on hypoxia measurements to determine "response to therapy" in pediatric soft tissue sarcomas as a pilot study.
- Trial name
- NCT03054792
- Testing
- Blood Oxygen Level Dependent [BOLD] MRI, Diffusion-Weighted [DW] MRI, Magnetic Resonance Spectroscopy [MRS]
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- The Hospital for Sick Children
Allergic Asthma
Safety and Repeatability of Bronchial Challenge With Grass-pollen
The study is meant to establish a one-step challenge with grass-pollen in patients sensitized for grass-pollen. Therefore the investigators compare a multi-step challenge with grass-pollen with an one-step challenge in order to…
- Trial name
- NCT00507039
- Testing
- inhalative grass-pollen provocation
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Parkinson Disease, Fall
Steps Against the Burden of Parkinson's Disease - RCT Kiel
Parkinson's disease (PD) affects over 10 million worldwide, causing unstable gait and falls in 70% of patients despite medication. This leads to confidence loss, isolation, fractures, and hospitalizations.
- Trial name
- StepuP (NCT07058285)
- Testing
- Speed-dependent treadmill training (SDTT), SDTT+ anteroposterior perturbations
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Kiel
Child Behavior Problem, Disruptive Behavior
Step-by-Step: Evaluation of a Stepped Care Model
The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems.
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06902649
- Testing
- Internet-based parenting support, "YourSkills" for children/youth, Step-by-step parent support
- Where
- Sweden
- Volunteers
- 210 people
- Sponsor
- Karolinska Institutet
Schizophrenia and Disorders With Psychotic Features
Specialized Treatment Early in Psychosis (STEP)
The purpose of this study is to understand the effectiveness of a specialized package of phase-specific treatments for individuals in the midst of their first episode of psychosis.
- Trial name
- STEP (NCT00309452)
- Testing
- Cognitive Behavioral Group Therapy, Cognitive remediation, Medications
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Sleep
Preterm Infants Physiological Parameters and Sleep-Wakefulness Status
This research was carried out between December 2021 and May 2022 as a randomized controlled experimental design. In the study, between 28-35 weeks of gestation preterm infants were divided into two groups as the experimental…
- Trial name
- NCT05673213
- Testing
- Three-stair positioning pillows group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Visceral Leishmaniasis
Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With VL
This is a phase II/III open, comparative dose trial to find the lowest single dose of AmBisome for the treatment of primary, symptomatic visceral leishmaniasis(VL), in HIV negative patients.
- Trial name
- NCT00832208
- Testing
- Liposomal amphotericin B (Ambisome)
- Where
- 3 sites in Ethiopia, Sudan
- Volunteers
- 124 people
- Sponsor
- Drugs for Neglected Diseases
Epilepsy in Children
Bad News- Diagnosis: Epilepsy in Childhood
"Bad news" are defined as"any information which adversely and seriously affects an individuals' view of future. Families of chronic ill children are exposed to a high stress load.
- Trial name
- Badnews (NCT03800992)
- Testing
- assessment of perception and evaluation of physicians advisory skills per questionnaire
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- University Hospital, Basel, Switzerland
Placenta Accreta Spectrum
Comparison Between 3 Conservative Surgeries for Placenta Accreta Spectrum
Comparison between modified one-step surgery vs. Segment Resection vs. placental bed suturing for management of placenta accreta spectrum
- Trial name
- NCT07520201
- Testing
- Modified one-step surgery, Segment Resection, Placental bed suturing
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
HIV
Streamlining Telehealth for Expanded PrEP Utilization Through Community Partnerships
The goal of this study is to learn if STEP-UP (Streamlining Telehealth for Expanded PrEP Utilization through community Partnerships) works to expand access to PrEP for people who could benefit from HIV prevention tools.
- Trial name
- STEP-UP (NCT07246057)
- Testing
- STEP-UP, Philadelphia TelePrEP Program Direct-to-Consumer Model
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Oligoarthritis, Juvenile, Polyarthritis, Juvenile, Rheumatoid Factor Negative
STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS
This study aims to compare the effectiveness of a conventional therapeutic regimen, based on treatment escalation (step-up strategy) and driven by the treat-to-target approach, with that of an early aggressive intervention based…
- Trial name
- STARS (NCT03728478)
- Testing
- Etanercept, Methotrexate, Intra-articular corticosteroid injections
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Istituto Giannina Gaslini
Cystic Fibrosis
The iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibrosis
The progression of lung disease in cystic fibrosis (CF) results inevitably in a reduction in exercise capacity. The assessment of fitness and exercise capacity in CF is an important measure of the impact of the disease process…
- Trial name
- NCT02199340
- Testing
- iStep exercise test, CPET exercise test
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hand Hygiene
SIMPLIFY the Hand Hygiene Procedure - Three Steps Versus Six Steps for Performing Hand Hygiene (SIMPLIFY Study)
Hand hygiene is one of the most important measures to prevent healthcare associated infections. A hand hygiene technique consisting of three steps may be superior to the 6-step technique outlined by the World Health Organization…
- Trial name
- SIMPLIFY (NCT04187040)
- Testing
- Study intervention: 3-step hand hygiene technique, Control intervention: 6-step hand hygiene technique
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Bimaxillary Protrusion
Evaluation of Mini and Macro-esthetics Following En- Masse Retraction Versus Two Step Retraction
There's a scarcity in literature concerning mini-esthetics specially maxillary gingival display changes following en-masse retraction and two-step retraction.
- Trial name
- NCT05150665
- Testing
- En-masse retraction, Two step Retraction
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Down Syndrome (DS)
Suspension Therapy Effects on Mobility and Balance in Down Syndrome
Down syndrome (DS) is one of the most common congenital disorders. Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular…
- Trial name
- STOMP (NCT06748248)
- Testing
- suspension Therapy, Routine Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Chronic Calculous Cholecystitis
Cystic Artery Preservation : an Additional Step for Safe Laparoscopic Cholecystectomy
Our aim is to feature additional steps for safe cholecystectomy by preserving the cystic artery.
- Trial name
- NCT07339501
- Testing
- The patients will be operated on for laparoscopic cholecystectomy with preservation of cystic artery a, The patients will be operated on for laparoscopic cholecystectomy with clipping or cauterization of cystic artery
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Suez University
Adolescent and Young Adult (AYA) Cancer Survivors
AYA STEPS RCT: AYA Self-Management Via Texting, Education & Plans for Survivors
The proposed project will leverage two programs of research at UPenn and CHOP that are delivering technology-based interventions to adolescent and young adult (AYA) cancer survivors.
- Trial name
- NCT03363711
- Testing
- AYA STEPS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma
In this study donor bone marrow transplantation is divided into a two step process to try to significantly reduce the side effects of the procedure yet still provide patients with multiple myeloma the benefits of this procedure
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT00003954
- Testing
- melphalan, autologous hematopoietic stem cell transplantation, autologous bone marrow transplantation
- Where
- 4 sites in United States, Italy
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center