Clinical trials: Stiffness
Hypertension, Retinal Artery Stenosis
Exercise, Arterial Modulation and Nutrition in Youth South Africa Study
The ExAMIN Youth SA study aims to generate new knowledge on the pathophysiology involved in early vascular aging among South African children and to identify early novel biological markers for predicting the subclinical…
- Conditions
- Hypertension, Retinal Artery Stenosis, Childhood Obesity
- Trial name
- ExAMIN-Youth (NCT04056377)
- Where
- South Africa
- Volunteers
- 1,065 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Healthy Adolescents
Activity Breaks for Brain Health in Adolescents
The main aim for this study is to investigate to what extent physical activity of moderate or low intensity, relative to prolonged inactivity, may acutely alter neural activity-related prefrontal cortex oxygenated hemoglobin…
- Trial name
- ABBaH teens (NCT04552626)
- Testing
- Prolonged sitting (social breaks), Prolonged sitting with step-up exercise break, Prolonged sitting with simple resistance activity breaks
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Persistent COVID-19, Quality of Life
Vascular Structure, Vascular Function and Vascular Aging in Adults Diagnosed With Persistent COVID
The ICOPER study aims to analyze the structure, vascular function, vascular aging and determining factors in 300 adults diagnosed with Persistent Covid in the field of Primary Health Care.
- Conditions
- Persistent COVID-19, Quality of Life, Lifestyles, Arterial Stiffness
- Trial name
- ICOPER (NCT05819840)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Foot, Footwear
Changes in Footwear Comfort and Performance in High School Football Players
The objective of this proposal is to determine the effects of footwear stiffness on a large cohort of high school football players during a football season.
- Trial name
- NCT02856360
- Testing
- Moderate Stiffness Footwear, High Stiffness Footwear
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- High Point University
Central Blood Pressure, Obesity
Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction
The global epidemic of obesity in childhood continues to evolve and threaten future health and life expectancy primarily due to the increased incidence of cardiovascular disease.
- Conditions
- Central Blood Pressure, Obesity, Subclinical Organ Damage, Children
- Trial name
- AORTA (NCT01310088)
- Testing
- Lifestyle intervention
- Where
- 2 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Aortic Stiffness, Oxidative Stress
Relationship Between Oxidative Stress and Aortic Stiffness
The goal of this clinical trial is to search about if there is any relationship between the aortic stiffness and oxidative stress response in adolescent football players.
- Conditions
- Aortic Stiffness, Oxidative Stress, Football Player
- Trial name
- NCT06590792
- Testing
- exhaustive exercise training session
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cystic Fibrosis
Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF
This project is an attempt to understand how Orkambi treatment affects exercise capacity and the function of the arteries in CF patients who are homozygous F508del.
- Trial name
- NCT03338595
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Augusta University
Prehypertension, Hypertension
Be-HealthY: Behavioral Risk Factors for Poor Vascular Health in Youth
The investigators aim to determine the association of dietary intake on cardiovascular disease risk factors among children with overweight and obesity who are being evaluated for elevated blood pressure.
- Conditions
- Prehypertension, Hypertension, Overweight and Obesity, Elevated Blood Pressure
- Trial name
- NCT03934398
- Testing
- Cardiovascular Assessments, Actigraphy, Laboratory assessments
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Micro-doses of Physical Activity for COPD
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than…
- Conditions
- Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension
- Trial name
- COPD (NCT05553223)
- Testing
- Microdoses of activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Cardiovascular Diseases, Arteriosclerosis
Simplified Pulse Wave Velocity Measurement, Validation Study of the pOpmètre in Children
Arterial stiffness is an important marker of cardiovascular risk. It is measured by pulse wave velocity. The reference device to measure pulse wave velocity is the Sphygmocor which uses applanation tonometry.
- Conditions
- Cardiovascular Diseases, Arteriosclerosis, Atherosclerosis
- Trial name
- EPIPOP (NCT02991703)
- Testing
- pOpmètre®, Sphygmocor
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Lipid Disorder, Dyslipidemias
Causal Mechanisms in Adolescent Arterial Stiffness
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear.
- Conditions
- Lipid Disorder, Dyslipidemias, Aortic Stiffness, Insulin Resistance Syndrome
- Trial name
- NCT04128969
- Testing
- CS+, CS-
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Transgenderism, Insulin Sensitivity/Resistance
Puberty Suppression and Cardiometabolic Health
This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin…
- Conditions
- Transgenderism, Insulin Sensitivity/Resistance, Endothelial Dysfunction, Vascular Stiffness
- Trial name
- NCT04482374
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Chronic Ankle Instability, Mulligan
Mulligan Ankle Taping on Volleyball Players
34 volunteer professional volleyball players with (n=12) and without (n=22) CAI will include in the study. Mulligan ankle taping will apply. Measurements will take before and after the intervention.
- Trial name
- NCT05757375
- Testing
- Mulligan Manuel Therapy Consept
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istinye University
Cerebral Palsy
Ankle-foot Orthoses for Night Splinting in Children With CP: Impact on Passive Stiffness in Plantarflexors Muscles
Children with cerebral palsy present early in the childhood altered muscular properties, characterized by short muscle belly length and increased stiffness which contribute to contracture and limiting joint range of motion.
- Trial name
- NIGHTSTRETCH (NCT03686644)
- Testing
- Wearing of night splint ankle foot orthoses (phase A), No wearing of night splint ankle foot orthoses (phase B)
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Liver Stiffness, Spleen Stiffness
Normal Pediatric Liver and Spleen SWE
This observational study aims to determine normal liver and spleen stiffness values in healthy children using shear wave elastography (SWE).
- Conditions
- Liver Stiffness, Spleen Stiffness, Shear Wave Elastography in Healthy Children, Normal Organ Elasticity
- Trial name
- SWE (NCT06930066)
- Where
- Turkey (Türkiye)
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Aortic Coarctation
Aortic Stiffness by CMR in Aortic Coarctation
This study investigates the correlation between medium-term systemic blood pressure control and aortic stiffness index in adults following coarctation stenting, using cardiac magnetic resonance (CMR) imaging.
- Trial name
- NCT06740461
- Volunteers
- 30 people
- Sponsor
- Assiut University
Liver Cirrhosis, Esophageal Varices
Two-dimensional Shear-Wave Elastography Evaluate Esophageal Varices Bleeding Risk of Liver Cirrhosis
The purpose of this retrospective study was to investigate the diagnostic performance of 2D-SWE for predicting the presence of esophageal varices and high-risk varices in patients with liver cirrhosis.
- Conditions
- Liver Cirrhosis, Esophageal Varices, Liver Stiffness
- Trial name
- NCT03989973
- Testing
- Gastroscopy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- West China Hospital
Forward Head Posture, Muscle Tone
Relationship Between Head Posture Muscles, Pulmonary Capacity and Functional Capacity: a Myotonometric Assessment
Forward head posture (FHP) is known to have a large influence on respiratory function by weakening the respiratory muscles. This cross-sectional study is designed to examine the relationship between the tonus, stiffness, and…
- Conditions
- Forward Head Posture, Muscle Tone, Muscle Stiffnes, Muscle Elasticty
- Trial name
- NCT04253821
- Testing
- muscle tonus, stiffness and elasticity,six-minute walk test, Pulmonary function tests, The neck disability index
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Cagtay Maden
Williams Syndrome, Supravalvular Aortic Stenosis
Impact of Elastin Mediated Vascular Stiffness on End Organs
Background: People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness.
- Conditions
- Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
- Trial name
- NCT02840448
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)