Clinical trials: Structural Conditions
Diparesis, Cerebral Palsy
Lower Extremity Evaluation in Children With Diparetic Cerebral Palsy According to ICF Perspective
Cerebral palsy (CP); is the most common neurodevelopmental disorder seen in childhood, characterized by permanent motor dysfunctions that develop due to brain damage occurring before birth, during birth, or in early childhood.
- Conditions
- Diparesis, Cerebral Palsy, Diplegic Cerebral Palsy, Lower Extremity Paresis
- Trial name
- NCT06583746
- Testing
- Group1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acıbadem Atunizade Hospital
X-Linked Myotubular Myopathy
A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition
XLMTM (X-linked myotubular myopathy) is a serious genetic muscle condition. It is caused by changes in the MTM1 gene which stops or slows down normal muscle development, causing severe muscle weakness.
- Trial name
- EXCEL (NCT06581146)
- Testing
- No Intervention
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 50 people
- Sponsor
- Astellas Gene Therapies
Disorder of Consciousness
Peripheral Inflammation and Brain Structural Alterations in Patients With Disorders of Consciousness.
Evidence suggests that inflammatory processes are key elements in the secondary effects of severe traumatic brain injury (TBI). The present study was designed to examine whether the peripheral inflammatory markers and brain…
- Trial name
- NCT03908541
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Eating Disorders, Psychiatric Comorbidities
Structural Brain Volumetry Changes in Eating Disorders.
The goal of this observational study is to investigate the relationship between structural brain changes and psychiatric comorbidities in individuals diagnosed with eating disorders (EDs).
- Trial name
- NCT07131852
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rare Diseases, Orphan Diseases
Dual Guidance Structure for Evaluation of Patients With Unclear Diagnosis in Centers for Rare Diseases
In people suffering from a rare disease the diagnostic process and the confirmation of a final diagnosis is often ongoing for many years.
- Trial name
- ZSE-DUO (NCT03563677)
- Testing
- dual expert guidance structure
- Where
- 12 sites in Germany
- Volunteers
- 1,379 people
- Sponsor
- Wuerzburg University Hospital
Congenital Cataract
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.
- Trial name
- NCT04976608
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wenzhou Medical University
Childhood Cancer, Cancer Survivors
Diaphragm Structure and Function in Childhood Cancer Survivors
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer…
- Trial name
- NCT06205251
- Testing
- POWERbreathe Plus IMT
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Maryland, Baltimore
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Mucopolysaccharidoses
Carotid Structure and Function in MPS Syndromes: A Multicenter Study of the Lysosomal Disease Network
Mucopolysaccharidosis (MPS) syndromes are disorders characterized by enzyme deficiencies, and they have been linked to heart health complications.
- Trial name
- NCT01586871
- Where
- 2 sites in United States
- Volunteers
- 1,147 people
- Sponsor
- University of Minnesota
Epilepsy Syndrome
Cognitive Impairments in Children With Epilepsy
Since the proportion of language and attentional difficulties in patients with epilepsy is recognized, both in the literature and in the clinical experience of practitioners, it is appropriate to propose a complete…
- Trial name
- NCT05097742
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Suicide Attempts
Epidemiology of Acute Self-poisoning in Emergency Services in France
Acute self poisoning is a leading cause of suicide attempts and leads to frequent emergency department visits. However, the exact epidemiology of acute self poisoning is not known.
- Trial name
- EpiTox (NCT02518386)
- Testing
- No intervention
- Volunteers
- 700 people
- Sponsor
- University Hospital, Grenoble
Speckle Tracking, Fetus Fetus
Speckle Tracking Echocardiography in Infants, Prenatally and Postnatally
Comparison of prenatal and postnatal cardiac function assessed by echocardiography using pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between foetuses/neonates with a structural heart disease…
- Conditions
- Speckle Tracking, Fetus Fetus, Neonate, Structural Heart Disease
- Trial name
- STIPP (NCT05601375)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Epithelial High Grade Serous Ovarian Cancer
Elements of Adaptive Immunity in Epithelial Ovarian Cancer
The study seeks to evaluate the presence and correlation with clinical outcome of several components of adaptive immunity (TILs, TLS, plasma cells and PD-L1 expression) in tumor specimens of patients with EOC treated with…
- Trial name
- NCT07528911
- Testing
- Assessment of elements of adaptive immunity in tumor biopsies
- Where
- Greece
- Volunteers
- 687 people
- Sponsor
- Hellenic Cooperative Oncology Group
STEMI
Relationship Between Level of GPCR Autoantibodies and Cardiac Structure & Funtions Based on UCG and CMR
This study is a prospective cohort study，we want to observe the changes of different cardiovascular antibody levels in STEMI patients undergoing emergency PCI;and combined with different cardiovascular antibody levels and various…
- Trial name
- NCT05368584
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Beijing Friendship Hospital
Ventricular Tachycardia, Myocardial Infarction
Cohort Study - SBRT for VT Radioablation
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar.
- Conditions
- Ventricular Tachycardia, Myocardial Infarction, Heart Disease Structural Disorder
- Trial name
- NCT04162171
- Testing
- Stereotactic Body Radiotherapy (SBRT) ablation of VT
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- John Sapp
Pediatric Obesity, Nutrition Disorder
A Positive Food Parenting Intervention to Promote Healthy Growth in Children at Risk for Obesity
This study is the pilot of a 12 - week positive food parenting intervention focused on structure-based and autonomy promoting practices.
- Trial name
- NCT06981429
- Testing
- Nourish to Flourish: The Power of Positive Food Parenting
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus
New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young subjects.
- Conditions
- Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus, Anomalous Coronary Artery Course, Anomalous Coronary Artery with Aortic Origin and Course Between the Great Arteries
- Trial name
- NECESSARY (NCT05159791)
- Testing
- Invasive coronary blood flow assessment and simulations and fluid dynamic patient specific simulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Policlinico S. Donato
Cerebral Palsy, Muscle Contraction
The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contraction, Muscle Spasticity
- Trial name
- CPBiopsyBTX (NCT05497609)
- Testing
- no intervention. Care as ususal
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ponten
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Longitudinal Studies of Brain Structure and Function in MPS Disorders
Neurobehavioral function and quality of life are compromised in many patients with mucopolysaccharidosis (MPS) disorders. The long-term goals of this research are to: 1) more accurately inform patients/parents regarding potential…
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI, Mucopolysaccharidosis Type IV
- Trial name
- NCT01870375
- Where
- 4 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- University of Minnesota