Clinical trials: Structural Conditions
Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion
New Non-invasive Modalities for Assessing Retinal Structure and Function
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other…
- Conditions
- Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy
- Trial name
- NCT03475173
- Testing
- LSFG-NAVI
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Chronic Obstructive Pulmonary Disease (COPD)
Effect on Structural Changes in Airways, Measured by MSCT, of Twice Daily 60mg AZD9668 for 12 Weeks in Chronic Obstructive Pulmonary Disease (COPD) Patients
The primary objective of the study is to evaluate structural changes effected by AD9668 in the airways of adults with Chronic Obstructive Pulmonary Disease (COPD) by Multi-Slice Computed Tomography (MSCT)
- Trial name
- NCT01054170
- Testing
- AZD9668
- Where
- 9 sites in Canada, Denmark and 3 more
- Volunteers
- 52 people
- Sponsor
- AstraZeneca
Schizophrenia, Catatonia
Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia
The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways. The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its…
- Trial name
- NCT02868879
- Testing
- Quantitative multiparametric and functional MRI
- Where
- France
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Wrinkles, Ageing
Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin
Objective of the study is to determine the influence of dietary supplementation with coenzyme Q10 (CoQ10) on skin conditions. 33 healthy female subjects will be randomly assigned to a placebo group, a low-dose (LD) group…
- Conditions
- Wrinkles, Ageing, Photoprotection
- Trial name
- NCT02604641
- Testing
- Quvital LD group, Quvital HD group
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Pediatric Obesity, Nutrition Disorder
A Positive Food Parenting Intervention to Promote Healthy Growth in Children at Risk for Obesity
This study is the pilot of a 12 - week positive food parenting intervention focused on structure-based and autonomy promoting practices.
- Trial name
- NCT06981429
- Testing
- Nourish to Flourish: The Power of Positive Food Parenting
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Diparesis, Cerebral Palsy
Lower Extremity Evaluation in Children With Diparetic Cerebral Palsy According to ICF Perspective
Cerebral palsy (CP); is the most common neurodevelopmental disorder seen in childhood, characterized by permanent motor dysfunctions that develop due to brain damage occurring before birth, during birth, or in early childhood.
- Conditions
- Diparesis, Cerebral Palsy, Diplegic Cerebral Palsy, Lower Extremity Paresis
- Trial name
- NCT06583746
- Testing
- Group1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acıbadem Atunizade Hospital
Postpartum Depression (PPD), Cardiac Event
Living Healthy for Moms RCT
LHMoms is a novel integrated care intervention that focuses intensively on care continuity and community-to-healthcare linkages for postpartum birthing individuals.
- Trial name
- LHMoms (NCT06666400)
- Testing
- LHMoms Intervention, No intervention
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Columbia University
Spinocerebellar Ataxia
Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia
The purpose of this research study is to investigate how the brain and motor behavior changes both in individuals with spinocerebellar ataxia and healthy individuals, and to assess whether a therapeutic intervention reduces…
- Trial name
- SCA (NCT02488031)
- Testing
- Error-reduction, International Cooperative Ataxia Rating Scale, Scale for the Assessment and Rating of Ataxia
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Fatigue
Alterations in Spiking Following Muscle Fatigue in Volleyball Players
This study aims (1)to investigate the effects of repetitive functional overhead movements targeting shoulder and scapular muscles on glenohumeral and scapular kinematics and muscle activation during the arm cocking and…
- Trial name
- NCT07687550
- Testing
- Upper Extremity Muscle Fatigue Protocol
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Skin Infections
Safety, Potential Efficacy, and Pharmacokinetics of PZ-601 in the Treatment of Complicated Skin and Skin Structure Infection
The purpose of this study is to evaluate the potential effect and safety of two different doses of PZ-601 and to compare this with another antibiotic that is approved by the US Food and Drug Administration (also known as FDA) to…
- Trial name
- NCT00671580
- Testing
- PZ-601, Standard of Care
- Where
- 15 sites in United States
- Volunteers
- 99 people
- Sponsor
- Protez Pharmaceuticals, Inc.
Cardiomyopathies, Ventricular Dysfunction
Measuring Electrical Resistance of Different Tissues on the Outer Surface of the Heart
This is a research study to evaluate the electrical properties of heart tissue. The purpose of this study is to determine the impedance (electrical resistance) of different tissues on the outer surface of the heart.
- Conditions
- Cardiomyopathies, Ventricular Dysfunction, Myocardial Infarction, Arrhythmia
- Trial name
- NCT00291174
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Aging, Inflammation
Relationship Between Thoracic Aortic Structure Assessed B PET/CT Scan and Arterial Stiffness in Elderly Patients
The purpose of this study is to determine the relationship between thoracic aortic inflammation and arterial stiffness in elderly patients.
- Trial name
- FICTEP (NCT01963221)
- Testing
- fludeoxyglucose(18f), blood sample, cardiac and aortic magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Hypertension
Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women
This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched…
- Trial name
- NCT03432468
- Testing
- Valsartan 1, Valsartan 80 mg
- Volunteers
- 102 people
- Sponsor
- LanZhou University
Disorder of Consciousness
Peripheral Inflammation and Brain Structural Alterations in Patients With Disorders of Consciousness.
Evidence suggests that inflammatory processes are key elements in the secondary effects of severe traumatic brain injury (TBI). The present study was designed to examine whether the peripheral inflammatory markers and brain…
- Trial name
- NCT03908541
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Analgesic Effects of Music
The Sedative Effects of Music Listening on Pain During Cold Pressor Test
This study aims to understand whether listening to music can reduce pain and anxiety caused by a cold-temperature stimulus in healthy young adults (n = 30).
- Trial name
- ESEMP (NCT07515196)
- Testing
- Phase 1 - Silence (Baseline), Phase 2 - Happy Mode with Measured Rhythm, Phase 3 - Sad Mode with Measured Rhythm
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rawane El Dimachki
Atrial Fibrillation
Henagliflozin in Patients With Atrial Fibrillation
The HENA-AF trial will evaluate the effects of henagliflozin on cardiac structure, function, and biomarkers of HF in patients with AF.
- Trial name
- HENA-AF (NCT05252624)
- Testing
- Henagliflozin 5Mg Tab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Anzhen Hospital
Nephrolithiasis
Kidney Stone Structural Analysis By Helical Computed Tomography (CT)
Current practices of the diagnosis of urinary stones gives little information on the probable fragility of stones using shock wave lithotripsy (SWL), and many patients receive more SW's than is necessary to break up their stones.
- Trial name
- NCT00169780
- Testing
- High definition helical CT (64 head scanner)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Indiana Kidney Stone Institute
Nemaline Myopathy, Myopathies
Natural History Study for Patients With Nemaline Myopathy in Spain
The objective of this natural history study is to comprehensively characterize the disease progression and clinical features of nemaline myopathies.
- Conditions
- Nemaline Myopathy, Myopathies, Myopathic Conditions, NEB
- Trial name
- NCT07488806
- Testing
- Muscle Ultrasound, Motor function scales, Complete physical examination
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hot Flashes
Investigating Magnesium Glycinate in Structure/Function Role of Hot Flashes.
The goal of this study is to further evaluate the effect of magnesium on the symptoms of menopause, specifically vasomotor symptoms (VMS) in breast cancer patients and/or women at an elevated risk of breast cancer.
- Trial name
- NCT03564665
- Testing
- 400mg Magnesium Glycinate BID
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Persistent Atrial Fibrillation
Effect of Catheter Ablation on Left Atrial Function in Persistent Atrial Fibrillation
A total of 106 patients with drug-refractory persistent atrial fibrillation, who are planned to undergo circumferential pulmonary vein isolation (CPVI), will be randomly allocated into two groups.
- Trial name
- NCT03443232
- Testing
- Cryoballoon ablation, Radiofrequency ablation
- Where
- China
- Volunteers
- 106 people
- Sponsor
- The Second Hospital of Hebei Medical University