Clinical trials: Sugammadex
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Neuromuscular Blockade, Delayed Emergence From Anesthesia
Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy
Sugammadex is routinely used to reverse rocuronium-induced neuromuscular blockade in children. In clinical practice, it is given either while the child is still deeply anesthetized or after the anesthetic has lightened.
- Conditions
- Neuromuscular Blockade, Delayed Emergence From Anesthesia, Emergence Agitation
- Trial name
- SUGA-PED (NCT07902193)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Namik Kemal University
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex for Conventional Reversal in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT04347486
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade
Comparing Reversal With Neostigmine and Sugammadex in Paediatric
A reversal agent is commonly given to improve neuromuscular function after intra-operative administration of non-depolarizing neuromuscular blocking agents.
- Trial name
- JS (NCT03137290)
- Testing
- Neostigmine, Sugammadex Sodium
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Appendicitis, Surgery
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
This study is designed as a randomized controlled trial with patients assigned to neuromuscular reversal with either sugammadex or neostigmine/glycopyrrolate reversal.
- Trial name
- NCT05256901
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Sugammadex
Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates
The primary aim of the work is to compare the efficacy of Sugammadex and neostigmine in reversing rocuronium-induced muscle relaxation to reach complete recovery of neuromuscular block (TOF ratio≥ 0.9) in preterm neonates.
- Trial name
- NCT04566796
- Testing
- Sugammadex, Neostigmine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Tonsillectomy
Muscle Relaxation for Pediatric Adenotonsillectomy
The goal of this clinical trial is to compare general anesthesia with muscle relaxation and reversal of the relaxation at the end of surgery or without muscle relaxation in high-risk children having adenotonsillectomy surgery.
- Trial name
- NCT06225466
- Testing
- Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Texas Southwestern Medical Center
Brain Cancer
Sugammadex Given for the Reversal of Rocuronium Induced Neuromuscular Blockade Under Sevoflurane Anesthesia in Infants
The objective of this study is to evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients
- Trial name
- NCT02708056
- Testing
- Sugammadex
- Volunteers
- 26 people
- Sponsor
- Baskent University
Emergence Delirium
Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
The aim of this study is to investigate the effect of sugammadex vs. a conventional acetylcholinesterase inhibitor, neostigmine on emergence delirium (ED) during sevoflurane-rocuronium anesthesia in pediatric patients…
- Trial name
- NCT03229486
- Testing
- Sugammadex Injection [Bridion], Neostigmine+Glycopyrronium
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Pusan National University Yangsan Hospital
Curarization, Postoperative Residual
A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old
Sugammadex is a drug used more and more frequently in infants as a rocuronium' s reversal agent. It has multiples benefits over other reversal agents such as a rapid onset of action and a complete reversal no matter how deep is…
- Trial name
- SUGAPEDIA (NCT07477132)
- Testing
- Sugammadex
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Caen
Neuromuscular Blockade
Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population
This randomized study prospectively evaluates our experience with administration of cisatracurium and rocuronium antagonized by sugammadex and evaluates the effects of various depths of neuromuscular blockage on providing optimal…
- Trial name
- PedLapBlock (NCT02546843)
- Testing
- Rocuronium, Cisatracurium, Nonspecific Neuromuscular Blockade reversal
- Where
- Czechia
- Volunteers
- 66 people
- Sponsor
- Brno University Hospital
Postoperative Vomiting, Postoperative Nausea
Sugammadex and Neostigmine in Pediatric Patients
In this study, it was aimed to compare the use of sugammadex instead of neostigmine + atropine in the reversal of NMB in children undergoing lower abdominal surgery or urogenital surgery, and to compare the rates of postoperative…
- Conditions
- Postoperative Vomiting, Postoperative Nausea, Postoperative Delirium
- Trial name
- NCT05618236
- Testing
- Group N; neostigmine+atropine, GROUP S; decurarized with sugammadex.
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Marmara University
Anesthesia
Dose-Finding Pediatric and Adult Trial With Sugammadex (Org 25969, MK-8616, SCH 900616) (19.4.306) (MK-8616-034) (P05961)
The purpose of this study is: to explore the dose-response relation of sugammadex (Org 25969, MK-8616, SCH 900616) given as a reversal agent at reappearance of T2 after 0.6 mg.kg-1 rocuronium in pediatric and adult participants…
- Trial name
- NCT00421148
- Testing
- Sugammadex 0.5 mg/kg, Sugammadex 1 mg/kg, Sugammadex 2 mg/kg
- Volunteers
- 94 people
- Sponsor
- Merck Sharp & Dohme LLC
Anesthetics, Inhalation, Neuromuscular Blockade
Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above.
- Conditions
- Anesthetics, Inhalation, Neuromuscular Blockade, Anesthesia, General
- Trial name
- NCT03795259
- Testing
- Rocuronium, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Neuromuscular Blockade
Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169)
This study will evaluate the efficacy, safety, and pharmacokinetics (PK) of sugammadex (MK-8616) for reversal of both moderate and deep neuromuscular blockade (NMB) in pediatric participants aged birth to <2 years.
- Trial name
- NCT03909165
- Testing
- Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Neostigmine + Glycopyrrolate
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 145 people
- Sponsor
- Merck Sharp & Dohme LLC
Incomplete Reversal of Neuromuscular Block
The Effect of Dexamethasone on Sugammadex Reversal
The purpose of this study is to determine whether dexamethasone extends the duration of recovery from anesthesia.
- Trial name
- NCT02137395
- Testing
- Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Spinal Curvatures
Effect of Sugammadex for Muscle Motor Response and Awareness in Intraoperative Wakeup
The study will be performed to evaluate motor response and awareness with using sugammadex during wakeup procedure in spine surgery.
- Trial name
- NCT02390817
- Testing
- Sugammadex, Neostigmine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University