Clinical trials: Sugammadex
Sugammadex
Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery
This is a single site, prospective, non-blinded, non-randomized, before/after study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative…
- Trial name
- NCT05886218
- Testing
- Quantitative Neuromuscular Function Monitoring
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of California, Davis
Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery
Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery
This prospective observational cohort study evaluates a precision neuromuscular management strategy in pediatric patients undergoing minimally invasive cardiac surgery (MICS).
- Conditions
- Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery, Early Extubation Pathway, TOF-Guided Sugammadex Administration
- Trial name
- TOF (NCT07798011)
- Testing
- Sugammadex
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Dr. Nguyen Thi Thu Hang
Neuromuscular Blockade Reversal Agent, Perioperative Complications
Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal
Study Objective: This study aims to evaluate the incidence, severity, and risk factors of sugammadex-induced mouth clenching during neuromuscular blockade (NMB) reversal in adult surgical patients.
- Conditions
- Neuromuscular Blockade Reversal Agent, Perioperative Complications, Anesthesia, General, Sugammadex
- Trial name
- NCT06962007
- Testing
- Sugammadex 1 mg/kg Group, Sugammadex 2 mg/kg Group, Sugammadex 4 mg/kg Group
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Neuromuscular Blocking Agents, Urinary Retention After Procedure
NMBA Reversal and Postoperative Urinary Retention
In this single-center retrospective cohort study of adult patients who underwent surgery under general anesthesia at Beth Israel Deaconess Medical Center between September 2016 and January 2024, the association between the choice…
- Conditions
- Neuromuscular Blocking Agents, Urinary Retention After Procedure, Urinary Retention Postoperative, Neuromuscular Blockade Reversal Agent
- Trial name
- NCT06948409
- Testing
- Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist])
- Where
- United States
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Craniectomy, Sugammadex
Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery
The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients…
- Conditions
- Craniectomy, Sugammadex, Extubation, Recovery After Neuromuscular Block
- Trial name
- NCT06987357
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Sugammadex Reversal Time, Muscle Weakness
The Effect of Methylprednisolone on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group
The aim of this study is to thoroughly investigate the interaction between methylprednisolone and sugammadex in the pediatric patient population.
- Trial name
- NCT06623370
- Testing
- methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Laparoscopic Bariatric Surgery, Sugammadex
Sugammadex on Laparoscopic Bariatric Surgery
Laparoscopic bariatric surgery has been recognized as the most effective treatment for obesity and related metabolic diseases. Because obesity patients often associated with sleep apnea syndrome or obesity hypoventilation…
- Trial name
- NCT06678451
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 60 people
- Sponsor
- Shanxi Bethune Hospital
Urinary Retention Postoperative, Laparoscopic Cholecystectomy
Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine Versus Sugammadex
This study is intended to be a single-site, prospective, randomized, controlled study that intends to enroll a total of 230 patients undergoing laparoscopic cholecystectomy at Parkland Hospital.
- Conditions
- Urinary Retention Postoperative, Laparoscopic Cholecystectomy, Neuromuscular Blockade, Sugammadex
- Trial name
- NCT05794503
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure
Sugammadex and Time to Extubation in Ophthalmic Surgery
This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.
- Conditions
- General Anesthesia Using Endotracheal Intubation, Ophthalmologic Surgical Procedure, Sugammadex, Neostigmine
- Trial name
- NCT06632067
- Testing
- sugammadex, Neostigmine + Atropine
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- China Medical University Hospital
Sugammadex, Extubation
Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex
After surgery is completed under general anesthesia, extubation is performed after recovery from anesthesia, and during this process, bucking, coughing, and rapid and excessive hemodynamic fluctuations occur very often.
- Conditions
- Sugammadex, Extubation, Smooth Emergence
- Trial name
- NCT05751603
- Testing
- sugammadex
- Volunteers
- 66 people
- Sponsor
- Ajou University School of Medicine
Sugammadex, Pregnant, Anesthesia
Sugammadex Administration in Pregnancy
In this study, the investigators aimed to evaluate the maternal and fetal effect of sugammadex in pregnant patients undergoing a non-obstetric surgery.
- Trial name
- NCT05708469
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Sakarya University
Sugammadex, Neostigmine
Neostigmine Versus Sugammadex on Renal Functions
The study will assess the acute effects of sugammadex or neostigmine on renal function as determined with more specific and sensitive tests in laparoscopic cholecystectomy
- Trial name
- NCT06081738
- Testing
- Neostigmine, Sugammadex
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Sugammadex, Motor Evoked Potentials
Effect of Muscle Relaxation Reversal on the Success Rate of Motor Evoked Potential Recording
Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during surgery without or with minimal neuromuscular blockade (NMB) because of its potential interference with signal interpretation.The…
- Trial name
- NCT04608682
- Testing
- Sugammadex, Saline
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Beijing Tiantan Hospital
Sugammadex
Comparative Efficacy and Safety of Sugammadex and Neostigmine
Along with unconsciousness and analgesia, use a muscle relaxant (Neuromuscular blocking agent NMBA) is now part of the classic triad of anesthesia.
- Trial name
- NCT04997759
- Testing
- Neostigmine and Sugammadex
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Neuromuscular Blockade, Sugammadex
Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine
Sugammadex may prevent residual neuromuscular blockade by providing rapid reversal at the end of the operation. Our goal is to compare the half-dose use of sugammadex for reversing residual blockade after administration of…
- Conditions
- Neuromuscular Blockade, Sugammadex, Neostigmine, Complication of Anesthesia
- Trial name
- NCT05066035
- Testing
- Neostigmine, Sugammadex
- Volunteers
- 113 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Diaphragm Ultrasonography, Liver Dysfunction
Diaphragm Ultrasound to Evaluate the Antagonistic Effect of Sugammadex
The use of muscle relaxants is an indispensable in the general anesthesia but is prone to accidents, which are often related to residual muscle relaxant.
- Conditions
- Diaphragm Ultrasonography, Liver Dysfunction, Sugammadex, Rocuronium
- Trial name
- NCT05028088
- Testing
- sugammadex
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sugammadex
The Effect of Sugammadex During Transcranial Electrical Motor Evoked Potential Monitoring in Spinal Surgery
Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during neurosurgical procedures without or with minimal neuromuscular blockade (NMB) because of its potential interference with signal…
- Trial name
- NCT04471376
- Testing
- Sugammadex
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Beijing Tiantan Hospital
Neuromuscular Blockade Reversal Agent, Sugammadex
Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine
The quality of recovery in patients who were reversed neuromuscular blockade by using Sumamadex and Neostigmine in laparoscopic cholecystectomy was compared through the QoR(Quality of Recovery)-15 questionnaire.
- Conditions
- Neuromuscular Blockade Reversal Agent, Sugammadex, Neostigmine, Quality of Recovery
- Trial name
- NCT04332627
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Bundang Hospital
Sugammadex
Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates
The primary aim of the work is to compare the efficacy of Sugammadex and neostigmine in reversing rocuronium-induced muscle relaxation to reach complete recovery of neuromuscular block (TOF ratio≥ 0.9) in preterm neonates.
- Trial name
- NCT04566796
- Testing
- Sugammadex, Neostigmine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Neuromuscular Monitoring, Sugammadex Effect
Intraoperative Methylprednisolone and Sugammadex
Sugammadex, a modified γ-cyclodextrin is a selective relaxant-binding agent that reverses the effects of steroidal neuromuscular blocking agents, rocuronium and vecuronium. It shows its activity by encapsulating these.
- Trial name
- NCT02025309
- Testing
- Neuromuscular monitorisation
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Ankara University