Clinical trials: Surfactant
Surfactant, Respiratory Distress Syndrome (Neonatal)
Comparing Surfactant Administration Through Supraglottic Airway and Thin Catheter for Preterm Infants
What is this study about? This study is comparing two ways of giving surfactant, a medicine that helps premature infants breathe better.
- Trial name
- SALTI (NCT07030270)
- Testing
- Surfactant Administration through Laryngeal or Supraglottic Airway, Surfactant Administration through Thin Catheter
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Surfactant Deficiency Syndrome Neonatal
deMISTify: The Impact of Ventilator Pressure Levels During Minimally Invasive Surfactant Therapy on Lung Aeration in Preterm Infants
Infants born preterm (before 36 weeks' gestation age) have immature lungs and struggle to breathe on their own. They are supported via respiratory machines like ventilators, as well as pharmaceutical aids like surfactant…
- Trial name
- deMISTify (NCT07522346)
- Testing
- Lung Recruitment Manoeuvre prior to Minimally Invasive Surfactant Therapy, Control (Minimally Invasive Surfactant Therapy)
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- Murdoch Childrens Research Institute
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Surfactant Dysfunction
Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial
The main objective is to determine the short-term effect of prone positioning in infants with infection-associated severe acute respiratory distress syndrome.
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Surfactant Dysfunction, Infant
- Trial name
- NCT05002478
- Testing
- Prone positioning
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Vienna
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Respiratory Distress Syndrome (Neonatal), Surfactant
Surfactant Using a Supraglottic Airway Device in Late Preterm to Early Term Infants
The purpose of this research is to learn new information that may help other infants that have respiratory distress syndrome and need breathing support after birth.
- Trial name
- SPLASH (NCT07176117)
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airway (SALSA), Continuous Positive Airway Pressure (CPAP)
- Where
- 3 sites in United States
- Volunteers
- 422 people
- Sponsor
- Sharp HealthCare
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants
Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure
Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management.
- Conditions
- Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
- Trial name
- NCT06446453
- Testing
- Echography-guided Surfactant THERapy (ESTHER)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Connecticut Children's Medical Center
Respiratory Distress Syndrome (Neonatal), Surfactant Deficiency Syndrome Neonatal
Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration
Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs.
- Trial name
- VID LISA (NCT07426016)
- Testing
- Video Laryngoscopy, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas Southwestern Medical Center
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS)
Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome
Respiratory distress syndrome (RDS) is a common cause of respiratory failure in preterm infants and is frequently treated with surfactant therapy.
- Conditions
- Respiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS), Surfactant
- Trial name
- NCT07350018
- Testing
- Poractant alfa, Calfactant
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 234 people
- Sponsor
- Uludag University
Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity
Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
The goal of this pragmatic clinical trial is to learn if the drug surfactant given by a less invasive technique works to treat respiratory distress in preterm infants in low- and middle-income African countries where invasive…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Premature Birth
- Trial name
- NCT06554522
- Testing
- Surfactant
- Where
- 8 sites in Central African Republic, Ghana and 2 more
- Volunteers
- 1,512 people
- Sponsor
- Indiana University
Surfactant Dysfunction
Hydroxychloroquin (HCQ) in chILD of Genetic Defect
The purpose of this proposed research is to investigate the efficacy and safety of hydroxychloroquine sulfate (HCQ, Quensyl) for pediatric ILD(chILD) caused by pulmonary surfactant-associated genes mutations.
- Trial name
- NCT03822780
- Testing
- Hydroxychloroquin
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Children's Hospital of Fudan University
Interstitial Lung Disease, Surfactant Dysfunction
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
The aim of this proposed study is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) in children's interstitial lung diseases(chILD) with genetic causes. This study is a randomized controlled clinical trial.
- Trial name
- NCT04532346
- Testing
- Hydroxychloroquine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Infant, Premature, Diseases, Respiratory Distress Syndrome
Pain Assessment During Less-Invasive-Surfactant-Administration
Primary aims of the study are to evaluate the feasibility of Skin conductance (SC) measurements and its correlation to Neonatal Pain and Distress Scale (N-PASS) - scores during the Less-Invasive-Surfactant-Administration…
- Conditions
- Infant, Premature, Diseases, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Pain
- Trial name
- PALISA (NCT06150586)
- Testing
- Skin Conductance (SC) Measurement, Video Recording
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Zurich
Premature Lungs, Respiratory Distress Syndrome
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life…
- Conditions
- Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- CaLI (NCT04209946)
- Testing
- Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Sharp HealthCare
Minimal Invasive Surfactant Administration in Two Different Non-invasive Ventilation Modes to NRDS Infants
NIV-MISA-NRDS Trial: a Multicenter Study in China
BACKGROUND Non-invasive ventilation (NIV) treatment have been developed to minimize lung damage and to avoid invasive mechanical ventilation (IMV) in preterm infants, especially in those with gestational age less than 30 weeks.
- Trial name
- NCT05137340
- Testing
- Nasal continuous positive airway pressure, Non-invasive positive pressure ventilation
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University Third Hospital
RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal
Surfactant Administration by Insure or Thin Catheter
This trial evaluates the efficacy and safety of surfactant administration with thin catheter technique together with analgesic premedication in comparison with the established INSURE-strategy.
- Conditions
- RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Analgesia
- Trial name
- SAINT (NCT04445571)
- Testing
- Thin catheter technique or standard ET-tube for surfactant administration
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Karolinska Institutet
Respiratory Distress Syndrome, Preterm Birth
Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Acute Respiratory Distress Syndrome, Surfactant Dysfunction
- Trial name
- NCT04777760
- Testing
- one dose of surfactant replacement, two and more doses of surfactant replacement
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome in Premature Infant
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment - Validation Study
The aim is to re-validate a FTIR spectroscopy test for measuring lung maturity/Respiratory Distress Syndrome (RDS) before conducting a RCT using this test to guide surfactant treatment of preterm infants.
- Trial name
- FAST2 (NCT05615428)
- Testing
- LS-ratio
- Where
- 3 sites in Denmark
- Volunteers
- 68 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn
Fast Assessment of Surfactant Deficiency in Preterm Infants to Speed up Treatment
Recently the investigators have developed a point of care test (LS-test) to measure surfactant as lecithin in gastric aspirates from preterm infants.
- Conditions
- Surfactant Deficiency Syndrome Neonatal, Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
- Trial name
- FAST2 (NCT05638568)
- Testing
- LS test
- Where
- 4 sites in Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS)
A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants
Many premature babies have breathing difficulty after birth and receive help with a breathing machine (nasal continuous positive airway pressure, NCPAP).
- Conditions
- Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Video Laryngoscopy, Surfactant
- Trial name
- NEU-VODEtec (NCT06758492)
- Testing
- Video laryngoscopy used to insert thin endotracheal catheter, Direct laryngoscopy used to insert thin endotracheal catheter
- Where
- 16 sites in Croatia, Czechia and 7 more
- Volunteers
- 600 people
- Sponsor
- University College Dublin