Clinical trials: Surfactant
SARS CoV 2 Infection, Alveolar; Injury
The Potential Role of sRAGE, KL-6, and SP-D as Prognostic Factors in Children With COVID-19
COVID-19 causes a wide spectrum of clinical illness, from upper respiratory symptoms to severe respiratory failure and death. Several plasma biomarkers -such as IL-6, C-reactive protein (CRP), D-dimer, the…
- Conditions
- SARS CoV 2 Infection, Alveolar; Injury, Children, Pneumonia, Viral
- Trial name
- NCT05619640
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Respiratory Distress Syndrome, Newborn, Premature Birth
Prophylactic Minimally Invasive Surfactant Evaluation
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation…
- Trial name
- PreProMISe (NCT06007547)
- Testing
- Poractant Alfa
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Poor Peripheral Perfusion
Perfusion Index Variability in Respiratory Distress Syndrome
Perfusion index may vary according to type of surfactant during the treatment of respiratory distress syndrome.
- Trial name
- NCT01852461
- Testing
- Beractant, Poractant alfa
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Pediculosis Capitis, Head Louse Infestation
Cocamide DEA vs Permethrin for Head Lice
To assess the efficacy and safety of 10% Cocamide DEA and Lyclear creme rinse (permethrin1%) in the eradication of head lice. To assess the ability of each product to kill all viable ova and to assess patient acceptability of the…
- Trial name
- NCT02500524
- Testing
- Cocamide diethanolamine, Permethrin
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical Entomology Centre
Pediculosis, Head Louse Infestation
Two Treatment Regimens of Cocamide DEA Lotion for Head Lice
To assess the efficacy and safety of 10% Cocamide DEA using two treatment regimens in the eradication of head lice. To assess the ability of each treatment regimen to kill all viable ova and to assess patient acceptability of the…
- Trial name
- NCT02499549
- Testing
- cocamide diethanolamine
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical Entomology Centre
Respiratory Distress Syndrome
Comparison of Efficacy of Less Invasive Surfactant Treatment Under Nasal CPAP and Nasal IPPV
Non invasive ventilation is important in the care of preterm infants with respiratory failure, and surfactant treatment can be use with non invasive ventilation.
- Trial name
- NCT04698473
- Testing
- NCPAP, NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Uludag University
Respiratory Tract Diseases
Budesonia + Intratracheal Surfactant in Incidence of Bronchopulmonary Dysplasia
Objectiv: To compare the effect of intratracheal administration of surfactant vs. surfactant/budesonide on the incidence of bronchopulmonary dysplasia in preterm infants less than 34 weeks of gestation.
- Trial name
- NCT05534685
- Testing
- intratracheal administration of surfactant/budesonide, incidence of bronchopulmonary dysplasia
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Respiratory Distress Syndrome, Preterm Birth
LISA vs INSURE in Extremely Low Birth Weight Infants. A Manikin Study
This is an unblinded, randomized, controlled, crossover (AB/BA) trial of surfactant treatment with LISA vs. INSURE in a manikin simulating an extremely low birth weight infant.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT04944108
- Testing
- LISA approach, Insure approach
- Where
- 2 sites in Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Heart Failure
Surfactant Derived Protocol in Heart Failure
Pulmonary surfactant is a highly surface-active lipoprotein complex that lines the alveoli and terminal airways, reducing surface tension and preventing alveolar collapse at the end of expiration.
- Trial name
- (SPB) (NCT06896461)
- Testing
- Cardiopulmonary exercise test, Lung function, Biomarkers evaluation
- Where
- Italy
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Lung Diseases, Respiratory Distress Syndrome, Newborn
Epidemiology of Surfactant Protein-B Deficiency
The purpose of this study is to test the hypothesis that excess, rare, functionally disruptive single nucleotide polymorphisms (SNPs) characterize genes (e.g., the surfactant protein-B gene)(SFTPB) and gene networks (e.g., the…
- Conditions
- Lung Diseases, Respiratory Distress Syndrome, Newborn, Pulmonary Surfactant, Lung Diseases, Interstitial
- Trial name
- NCT00014859
- Where
- United States
- Volunteers
- 5,176 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine