Clinical trials: Syncope and Collapse
Syncope, Vasovagal
Different Catheter Ablation Strategy in Vasovagal Syncope
This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1.
- Trial name
- NCT05573178
- Testing
- cardiac ganglion plexus ablation(cardioneuroablation)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- China National Center for Cardiovascular Diseases
Vasovagal Syncope, Postural Tachycardia Syndrome
Mechanisms of Vasovagal Syncope
Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness.
- Trial name
- NCT01791816
- Testing
- Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Posttraumatic Stress Disorder, Pseudopheochromocytoma
Clinical Autonomic Disorders: A Training Protocol
Background: The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia.
- Conditions
- Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope
- Trial name
- NCT02154009
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Coronary Syndrome, Heart Failure
A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa
FEVRIER study is an observatory of hospitalizations in cardiology units in sub-Saharan Africa.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Syncope, Stroke
- Trial name
- FEVRIER (NCT03231449)
- Testing
- observation of current care
- Where
- 20 sites in Benin, Burkina Faso and 11 more
- Volunteers
- 5,000 people
- Sponsor
- Cardiologie et Développement
Vagal Syncope
Validation of a Non Invasive Blood Marker of SIDS and Vagal Disorders
Context The investigators recently demonstrated a highly significant increase in muscarinic receptor density in the myocardium of infants deceased from sudden infant death syndrome (SIDS) compared to those of infants deceased…
- Trial name
- NCT01358461
- Testing
- Blood sampling, ECG-Holter 24 h tape and sino-carotid stimulation test
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Presyncope, Arrhythmias, Cardiac
The IPED (Investigation of Palpitations in the ED) Study
Palpitations (noticeable pounding, fluttering or irregular heart beat) and pre-syncope (near blackout) are common ED problems sometimes due to an abnormal cardiac rhythm.
- Conditions
- Presyncope, Arrhythmias, Cardiac, Tachycardia, Supraventricular, Atrial Fibrillation
- Trial name
- IPED (NCT02783898)
- Testing
- AliveCor Heart Monitor
- Where
- 10 sites in United Kingdom
- Volunteers
- 243 people
- Sponsor
- NHS Lothian
Syncope
Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital
Evaluation of commitment of resident physician to the guidelines as regard management of cases of syncope at Assiut University Children Hospital and correction of the defect that will be discovered.
- Trial name
- NCT04575376
- Volunteers
- 30 people
- Sponsor
- Assiut University
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Syncope, Syncope;Heat Induced
Validation of a Novel Simplified Head up Tilt Test (HUTT) Protocol Versus the Conventional Protocol
The purpose of the study is to compare the positivity rate associated with a novel simplified Tilt-Table (TT) test protocol versus the conventional TT protocol
- Trial name
- NCT05029323
- Testing
- Fast HUTT, Conventional HUTT
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Consciousness Disorder
A Clinical Decision Aid for Diagnosing Transient Loss of Consciousness
BACKGROUND: Transient loss of consciousness (TLOC) - defined as spontaneous disruption of consciousness not due to head trauma and with complete recovery - has a lifetime prevalence of 50%.
- Trial name
- NCT05367999
- Testing
- initial Paroxysmal Event Profile
- Where
- 2 sites in United Kingdom
- Volunteers
- 186 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Syncope, Neurogenic, Syncope
Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope
The third study on CardNM (CardNMH3 study) is a multicenter, double-blind, randomized trial with a sham control group investigating the efficacy and safety of a computed tomography (CT)-guided, right-sided ablation of the…
- Trial name
- CardNMH3 (NCT04755101)
- Testing
- EPS, electro-anatomical mapping, ARGP ablation, and pharmacological evaluation., EPS, electro-anatomical mapping, and pharmacological evaluation.
- Where
- 3 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Imelda Hospital, Bonheiden
Syncope
Rapid Measurement of Adenosine in Syncope Patients
Until now, a barrier to the widespread evaluation of adenosine in clinical practice has been the difficulty of obtaining rapid reliable measures.
- Trial name
- BlotSpot (NCT05782712)
- Testing
- adenosine dosage
- Where
- Italy
- Volunteers
- 235 people
- Sponsor
- Istituto Auxologico Italiano
Implantable Loop Recorder
Bradycardia Risk Stratification With Loop Recorder After Syncope
Syncope is a common symptom that may be related to a conductive disorder. If no bradycardia is authenticated, it is often necessary to implant an implantable loop recorder.
- Trial name
- NCT04200014
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal
Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects
Dysautonomia, primarily defined as postural orthostatic tachycardia syndrome (POTS) can seriously disrupt a child's daily activities. It is most commonly associated with nausea or abdominal pain.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal, Neurocardiogenic Syncope
- Trial name
- POTS (NCT01617616)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wake Forest University Health Sciences
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Postural Orthostatic Tachycardia Syndrome (POTS), Syncope
Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
Postural orthostatic tachycardia syndrome (POTS) is a common cause of orthostatic intolerance in adolescents and adults. Compression stockings are commonly recommended as a treatment modality for POTS, but the effects of…
- Trial name
- NCT01795469
- Testing
- Zoex compression garment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nationwide Children's Hospital
Syncope, Vasovagal
Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery
Patients's demographics and perioperative factors affect the occurrence of hypotensive bradycardic events in the patients undergoing arthroscopic shoulder surgery in the sitting position under interscalene block.
- Trial name
- NCT01926561
- Testing
- Interscalene brachial plexus block
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Syncope
NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness
This study is designed to evaluate the accuracy of the National Institute for Health and Clinical Excellence (NICE) guideline 'red flags' to identify patients at high risk of short term serious outcome when presenting in the…
- Trial name
- NCT01498471
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aortic Stenosis, Heart Failure
High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)
TASS-2 (Tyrolean Aortic Stenosis Study-2) aims to characterize the clinical value of minimally elevated troponin T plasma levels both in patients with asymptomatic and symtomatic aortic stenosis.
- Conditions
- Aortic Stenosis, Heart Failure, Syncope, Angina Pectoris
- Trial name
- TASS-2 (NCT02448485)
- Testing
- Aortic Valve Intervention (surgical or transcatheter)
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Medical University Innsbruck