Clinical trials: Systemic Inflammation
SEPSIS, MALNUTRITION, CHILD
Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children
Children with severe malnutrition who are sick and admitted to hospitals have high mortality, usually because of infection. Malnourished children have more potentially harmful bacteria in their upper intestines than…
- Trial name
- PB-SAM (NCT04542473)
- Testing
- Pancreatic Enzyme, Ursodeoxycholic acid
- Where
- 4 sites in Bangladesh, Kenya and 2 more
- Volunteers
- 400 people
- Sponsor
- University of Oxford
Sepsis
Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
The overall objective of this proposed research is the derivation of a biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) (software) that can be used in combination with the hospital's…
- Trial name
- NCT05311046
- Testing
- Pediatric sepsis screening tool (either algorithmic or manual)
- Where
- United States
- Volunteers
- 12,961 people
- Sponsor
- Computer Technology Associates, Inc.
Late Onset Neonatal Sepsis
Neonatal Vancomycin Trial
The study aims to compare the efficacy, safety and pharmacokinetics (PK) of an optimised dosing to a standard dosing regimen of vancomycin in neonates and infants aged ≤ 90 days with late onset bacterial sepsis known or suspected…
- Trial name
- NeoVanc (NCT02790996)
- Testing
- Vancomycin
- Where
- 18 sites in Estonia, Greece and 3 more
- Volunteers
- 242 people
- Sponsor
- PENTA Foundation
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
Neonatal Late Onset Sepsis
Pentoxifylline and Late Onset Sepsis in Preterm Infants
Hypothesis: The investigators hypothesized that Pentoxifylline has potent anti-inflammatory effect which can augment the antimicrobial effect of antibiotics in treatment of Late onset sepsis (LOS) in preterm infants thus…
- Trial name
- NCT02163174
- Testing
- Pentoxifylline (PTX)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Abd Elazeez Attala Shabaan
Fever, Mycoses
Phase I Study of the Safety, Tolerance, and Pharmacokinetics of FK463 in Immunocompromised Children With Fever and Neutropenia
The objective of this study is to evaluate the safety, tolerance, and pharmacokinetics of FK463, a novel echinocandin (cell wall-active antifungal lipopeptide), as early empirical therapy for prevention of fungal infections in…
- Conditions
- Fever, Mycoses, Neutropenia
- Trial name
- NCT00001790
- Testing
- FK463
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Newborn Sepsis
Clinical Criteria for a Pathogen in Term Newborn Suspected of Neonatal Sepsis
Neonatal early onset sepsis (EOS) diagnosis is difficult due to lack of sensivity and specificity markers. The investigators conduced a restrospectif study to all term born infants born between 1 january and 31 December 2013 and…
- Trial name
- IMF-NN (NCT03623503)
- Testing
- Observational study
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Candidemia
SIHAM Candidemia Network:An Observational Study
Title: A multicenter observational study of candidemia cases among ICU patients in India Objective: Primary objective: Determine epidemiological and also clinical parameters of candidemia cases among ICU patients in India.
- Trial name
- NCT01281345
- Where
- India
- Volunteers
- 1,400 people
- Sponsor
- Society of Indian Human & Animal Mycologist
Liver Transplantation, Infection
Italian National Study on the Critically Ill Liver Transplant Patient With an Infection
Despite major advances, infections remain one of the major causes of morbidity and mortality in patients undergoing orthotopic liver transplantation (OLT).
- Conditions
- Liver Transplantation, Infection, Sepsis, Intensive Care Unit
- Trial name
- INFE-OLT (NCT03363646)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Neonatal Sepsis
Role of Antibiotics in Preventing Infection in Babies Born Through Meconium Stained Liquor
The purpose of the study is to evaluate the role of antibiotics in preventing infection in babies born through meconium stained amniotic fluid. Normally babies do not pass meconium while in utero.
- Trial name
- AbProM (NCT01290003)
- Testing
- Piperacillin-Tazobactam and Amikacin
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Lady Hardinge Medical College
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) as assessed by standard of care vasopressor dose reduction in pediatric patients with catecholamine-resistant hypotension…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Septic Shock
- Trial name
- NCT03623529
- Testing
- LJPC-501 (angiotensin II)
- Where
- 2 sites in Belgium, Lithuania
- Volunteers
- 100 people
- Sponsor
- La Jolla Pharmaceutical Company
Sepsis
Serum Albumin Ratios Can Improve Sepsis Mortality Prediction
Sepsis remains a leading cause of mortality in hospitalized patients, despite advancements in critical care. Existing clinical scores for predicting sepsis outcomes often lack generalizability and complexity, hindering accurate…
- Trial name
- NCT06640504
- Testing
- serum albumin, C-Reactive Protein, Serum procalcitonin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
LRTI, Sepsis
Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis
The TAILORED-Treatment consortium was established to develop new tools aimed to increase the effectiveness of antibiotic and antifungal therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in…
- Conditions
- LRTI, Sepsis, Fungal Infections, Bacteremia
- Trial name
- TailoredT (NCT02025699)
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Septic Shock
Continuos Terlipressin Infusion in Septic Shock
The purpose of this study is to evaluate the efficacy of terlipressin for treating septic shock.
- Trial name
- NCT01697410
- Testing
- Terlipressin, Norepinephrine
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Sepsis, Umbilical Cord
Perinatal Handwashing Intervention in Bangladesh
The purpose of this study is to determine if an intensive handwashing intervention administered to primiparous women during their pregnancy can increase maternal handwashing with soap at critical times.
- Conditions
- Sepsis, Umbilical Cord, Infection
- Trial name
- NCT01309321
- Testing
- Perinatal Handwashing Promotion, Neonatal Health Promotion
- Where
- Bangladesh
- Volunteers
- 400 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Sepsis
Management of Sepsis in Resource Limited Settings Using a Delphi Method.
Rapid evolution of sepsis syndromes means that timely diagnosis and treatment are critical in improving outcomes but this may be difficult to achieve in many low- and middle- income countries (LMICs) and there is a lack of high…
- Trial name
- NCT05909384
- Testing
- Survey
- Where
- Vietnam
- Volunteers
- 36 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Neonatal Early-onset Sepsis
Cahnge in Management of Suspected Early Onset Neonetal Sepsis After Assimilation of Early Onset Sepsis Calculator
Early neonatal sepsis requires rapid and efficient intervention to prevent morbidity and mortality. Management of such a case includes invasive blood examinations, elongation of maternal and neonatal length of stay, and empiric…
- Trial name
- NCT06643052
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 6,300 people
- Sponsor
- Hillel Yaffe Medical Center