Clinical trials: T1DM
Type1 Diabetes Mellitus
Efficacy of inControl Advice: A Decision Support System (DSS) for Diabetes
The purpose of this study is to reduce the frequency of hypoglycemia and severe hypoglycemic events in subjects who use insulin pens to treat their Type 1 Diabetes Mellitus (T1DM).
- Trial name
- DSS (NCT03093636)
- Testing
- Continuous Glucose Monitor (CGM)+Decision Support System (DSS), Continuous Glucose Monitor (CGM) alone
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus (T1DM), Parent
Comprehensive Intervention to Promote Adjustment in Adolescents With Type 1 Diabetes and Their Parents During Transfer of Health Care Responsibility
Introduction: Type 1 diabetes mellitus is a health condition that produces physical and psychosocial alterations in both the person the person with diabetes mellitus and his or her family, that is why interventions should be…
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Parent, Adolescent, Nursing
- Trial name
- NCT07886307
- Testing
- CONEXIÓN ADAPTAR - DM1, Usual Care
- Where
- 2 sites in Colombia
- Volunteers
- 34 people
- Sponsor
- Universidad de la Sabana
Diabetes Mellitus, Type 1, Immunologic Deficiency Syndromes
Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM
This study evaluates the efficacy of sequential transplantation of umbilical cord blood stem cells and islet cells in children with monogenic immunodeficiency type 1 diabetes mellitus.
- Trial name
- NCT03835312
- Testing
- Sequential transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Fudan University
T1DM
Efficacy of Hyperbaric Oxygen Therapy (HBOT) in New-onset Type-1 Diabetes Mellitus
Type 1 Diabetes Mellitus (T1DM) is caused by an autoimmune process that progressively destroys the pancreatic β-cells, and leads to dependence on multiple daily insulin subcutaneous injections according to glucose measurements…
- Trial name
- NCT04412200
- Testing
- Hyperbaric oxygen chamber (HBOC)
- Where
- 2 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Assaf-Harofeh Medical Center
Hypoglycemia
Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children
A phase 3, randomized, double-blind, placebo- and active-controlled, parallel-arm trial to assess the efficacy, safety, and pharmacokinetics of dasiglucagon relative to placebo and GlucaGen® when administered as a rescue therapy…
- Trial name
- NCT03667053
- Testing
- dasiglucagon, GlucaGen HypoKit
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 42 people
- Sponsor
- Zealand Pharma
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Type 1 Diabetes (T1D), Type 1 Diabetes Mellitus (T1DM)
Structured Education Program and Glycemic Control in Adolescents With Type 1 Diabetes
Type 1 diabetes is becoming more common in Kuwaiti and Arab adolescents. Many young people with this condition struggle to keep their blood glucose levels under control, which can lead to diabetes-related complications and affect…
- Trial name
- NCT06984133
- Testing
- Structured education program
- Where
- Kuwait
- Volunteers
- 128 people
- Sponsor
- Dasman Diabetes Institute
Diabetes Mellitus, Insulin-Dependent
Safety and Pharmacokinetics (PK) of hOKT3g1 (Ala-Ala) in Type 1 Diabetes Mellitus (T1DM)
To assess the tolerability and safety of hOKT3g1 (Ala-Ala) after a 12-day dosing regimen administered via intravenous infusion. To assess the pharmacokinetics of hOKT3g1 (Ala-Ala).
- Trial name
- NCT00073255
- Testing
- hokt3g1 (ALA-ALA)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus
T1DM Clinical Onset and Progression in Paediatric Population
Diabetes Mellitus Type I is the chronic metabolic disease of childhood with the highest incidence in developed countries. Over the past 10 years the incidence of diabetes has been increased especially in immigrants children.
- Trial name
- Bioda (NCT03547440)
- Where
- 3 sites in Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Type 1 Diabetes Mellitus (T1DM), Motivational Interviewing
Motivational Interviewing and WhatsApp-Based Monitoring for Metabolic Control and Self-Efficacy in Adolescents With T1DM
This clinical study aims to determine the effects of motivational interviewing and social media-based patient monitoring on metabolic control and self-efficacy in adolescents with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Motivational Interviewing, Metabolic Control
- Trial name
- NCT06635460
- Testing
- Motivational interviewing, Social media-based patient monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul Medeniyet University
Effect of Change in T1DM Glycemic Control
Effect of Metformin in Children With Type 1 Diabetes
Cardiovascular disease is the leading cause of mortality in type 1 diabetes mellitus (T1DM). Vascular dysfunction is an early and critical event in the development of cardiovascular disease.
- Trial name
- NCT04879511
- Testing
- metformin, Basal/bolus insulin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 1
A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part II
Aralast NP (alpha-1 antitrypsin, AAT), an alpha-1 proteinase inhibitor (human), was the drug to be tested in this clinical trial.
- Trial name
- RETAIN (NCT01183455)
- Testing
- Aralast NP
- Where
- 15 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Improving Metabolic Control in Diabetic Young Children
: Although intervention or prevention with young children with T1DM may help ameliorate problems or forestall later problems in metabolic control, a number of potential barriers to research have constrained the development of…
- Trial name
- NCT00439985
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 1 Diabetes, C-peptide
C-peptide Correlation With Microvascular Complications in T1DM
The purpose of this study is to investigate the presence of residual insulin secretion in patients with DM1 and its correlation with the possible protection against early microvascular and macrovascular complications, emphasizing…
- Conditions
- Type 1 Diabetes, C-peptide, Diabetes Complications
- Trial name
- NCT04474535
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Type 1 Diabetes Mellitus
Hypoglycemia Prevention After Exercise in Adolescent T1DM Patients Using a Control to Range System
In this protocol the investigators plan to demonstrate management of glucose using a modular insulin management system based on continuous glucose monitoring and targeted towards the avoidance of hypoglycemic and prolonged…
- Trial name
- MDB005 (NCT01390259)
- Testing
- Open-Loop, Closed-Loop
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus (T1DM)
Prospective Cohort Study of Children Diagnosed with Type 1 Diabetes in Türkiye Between 2018 to 2022
Achieving glycemic targets with improved T1DM management reduces diabetes complications and the risk of progression. Thus, it is essential to identify the challenges in T1DM management within the country and develop strategies…
- Trial name
- NCT06892821
- Where
- Turkey (Türkiye)
- Volunteers
- 2,730 people
- Sponsor
- Turkish Pediatric Diabetes Working Group
New-onset Type 1 Diabetes Mellitus
Inducing Remission in Type 1 Diabetes With Alefacept
The purpose of this trial is to test whether a drug called alefacept will slow or halt destruction of the beta cells in the pancreas.
- Trial name
- T1DAL (NCT00965458)
- Testing
- Alefacept
- Where
- 15 sites in United States
- Volunteers
- 49 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
T1DM
Glycemic Control and Quality of Life With i- Port Advance in Pediatric T1DM
The incidence of T1DM in children, especially infants under 4 years of age, is increasing in the last decade. Not all patients are willing or able, from different reasons, to be treated with insulin pumps.
- Trial name
- NCT04428762
- Testing
- I-Port Advance use
- Sponsor
- Assaf-Harofeh Medical Center
Type1diabetes, Fasting
Early Versus Late Administration of Insulin Glargine in T1DM During Fasting Ramadan
To compare different timing of insulin Glargine administration (early-6 pm versus standard bedtime-10 pm) as part of standard of care in patients with type1 diabetes who wish to fast the month of Ramadan.
- Conditions
- Type1diabetes, Fasting, Insulin
- Trial name
- NCT04383990
- Testing
- Timing of taking insulin
- Where
- Saudi Arabia
- Volunteers
- 185 people
- Sponsor
- King Abdullah International Medical Research Center
T1DM - Type 1 Diabetes Mellitus
The True Vie I3 Continuous Glucose Monitoring System in Pediatric Patients With Type 1 Diabetes Mellitus
The purpose of the investigation is to evaluate the performance of the I3 CGM in Pediatric Patients with Type 1 Diabetes Mellitus (T1DM) according to the FDA's special controls for iCGM.
- Trial name
- NCT05908448
- Testing
- 13 CGM (continuous glucose monitor)
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Sinocare