Clinical trials: Targeted Therapy
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Reducing Tuberculosis Incidence
DeMONSTRATE-TB Study in Ethiopia
Ending the TB epidemic by 2035 in Ethiopia would be possible if TB notification declines by an annual factor of at least 15% from the current notification rate of 132 per 100,000 population.
- Trial name
- NCT06719193
- Testing
- Enhanced community-wide TB intervention, Routine TB program activities
- Where
- 2 sites in Ethiopia
- Volunteers
- 131,438 people, healthy volunteers welcome
- Sponsor
- Management Sciences for Health
Death, Death, Infant
Coupons for Safe Water Project
Guaranteeing access to safe drinking water is still a challenge in rural households in developing countries, and unsafe water sources are responsible for millions of deaths each year around the world.
- Conditions
- Death, Death, Infant, Diarrhea, Diarrhea, Infantile
- Trial name
- Coupons (NCT05766826)
- Testing
- Coupons for safe water program: Treatment, Coupons for safe water program: Control
- Where
- 2 sites in Kenya
- Volunteers
- 3,468 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Recurrent UTIs, Catheter-Related Infections
Novel Probiotic Treatment for Prevention of Recurrent UTIs in Children
Background: Urinary tract infections (UTIs) are a common and costly cause of doctor visits for children. Frequent UTIs trigger kidney damage that leads to serious diseases like high blood pressure, pregnancy complications, and…
- Trial name
- Nissle 1917 (NCT01696227)
- Testing
- Nissle 1917
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Pediatric Obesity
Pediatric Obesity Observational Prospective Trial
Using an observational case-control cohort design, the investigator aims to define the mechanisms underlying microbiome regulation of metabolism in adolescence before and after medically indicated therapies for obesity.
- Trial name
- NCT03139877
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Duke University
Dissociation, Auditory Hallucination
Psychological Therapy for Dissociation, Trauma and Voices: A Single Case Experimental Design
Connection to Environment with Cognitive Therapy (CONNECT): A Single-Case Experimental Design Exploring Dissociative Experiences and Voices Emerging empirical evidence has suggested that dissociation is a robust determinant of…
- Conditions
- Dissociation, Auditory Hallucination, Trauma, Psychological, Psychosis
- Trial name
- CONNECT (NCT04127526)
- Testing
- Connection to Environment with Cognitive Therapy (CONNECT)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Neuroblastoma
A Pilot Study on ALK Gene Mutations in Neuroblastoma
Neuroblastoma (NB) originates from the sympathetic nervous system and is one of the most common cancers in infants and children.
- Trial name
- NCT01986595
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pregnancy
Therapeutic Omegas for Triglyceride Suppression
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood.
- Trial name
- TOTS (NCT04349475)
- Testing
- Intervention Omega 3 Supplementation
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Gut Microbiota as a Therapeutic Target for CVD
Background: The Mediterranean Diet (MD) is considered an healthy diet useful in the prevention of cardiovascular disease (CVD). High quality extra virgin olive oil (HQ-EVOO, [1]), an essential component of this diet, exerts a…
- Trial name
- oliomicroFDG (NCT03441802)
- Testing
- High quality extra virgin olive oil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Depression, Depressive Disorder
Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions
Major depression (MD) in youth is a serious psychiatric illness with extensive morbidity and mortality. The American Academy of Pediatrics recently released practice guidelines promoting primary care (PC)-based youth MD…
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT04066985
- Testing
- Growth Mindset Online Single-Session Program, Self-Kindness Online Single-Session Program, Supportive Therapy Online Single-Session Program (Control)
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Child Mind Institute
Childhood Obesity
Childhood Obesity Treatment Targeting Specific Behaviors
The US is in the midst of an obesity epidemic, affecting young children. The pediatric primary care setting is an ideal place to address this problem since most families have frequent contact with their pediatrician and a child's…
- Trial name
- NCT00259324
- Testing
- Diet and Activity
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Crohn's Disease, IBD
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)
Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents.
- Trial name
- ENvISION (NCT04131504)
- Testing
- Infliximab, Adalimumab
- Where
- 4 sites in United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Emotion Regulation Disorders
Virtual Reality Exposure Therapy for Emotion Regulation Difficulties in Adolescent Inpatients
The goal of this clinical trial is to evaluate whether a therapist-guided virtual reality (VR)-based intervention can improve emotion regulation in adolescents receiving inpatient psychiatric treatment.
- Trial name
- VRsafe (NCT07709468)
- Testing
- Virtual Reality Exposure Therapy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Malaria
Seasonal Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine in Children in Mali
Recent, randomized controlled trials conducted in areas of perennial malaria transmission have shown that intermittent preventive treatment (IPT) given at the time of vaccination reduced the incidence of the first episode of…
- Trial name
- NCT00623155
- Testing
- Seasonal IPT in children - Sulfadoxine-pyrimethamine
- Where
- Mali
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Hemodynamically Significant Patent Ductus Arteriosus
Research on the Individualized Treatment Strategy for Extremely Preterm Infants With hsPDA Based on Biomarkers and Targeted Delivery Systems
This project aims to address the need for individualized precision therapy for hemodynamically significant patent ductus arteriosus (hsPDA) in extremely preterm infants by integrating clinical biomarker screening with the design…
- Trial name
- BTDS-IT-hsPDA- (NCT07374146)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Utilization, Health Care, Birth Outcomes
Improving Perinatal Outcomes Using Conditional and Targeted Transfers
It has been estimated that increasing the use of skilled care during childbirth could prevent up to 1.5 million maternal and newborn deaths and stillbirths by 2025.
- Trial name
- IMPACTT (NCT04090762)
- Testing
- Conditional cash transfer, Risk information provision
- Where
- Nigeria
- Volunteers
- 36,607 people, healthy volunteers welcome
- Sponsor
- RAND
Functional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome
Targeted Food Elimination for Treatment of Functional Gastrointestinal Diseases in Children
Recurrent Abdominal Pain (RAP) in children is common and causes significant functional impairment and poor quality of life. Lifestyle factors such as diet, anxiety, and stress are important triggers of abdominal pains, but there…
- Conditions
- Functional Gastrointestinal Disorders, Functional Abdominal Pain Syndrome, Abdominal Pain (AP)
- Trial name
- FGID (NCT02565355)
- Testing
- Dietary Exclusion, Standard Treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Malaria, Anaemia
IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting
It is generally agreed that artemisinin-based combination therapy (ACT) is the malaria therapy of choice but there is much less agreement about the best ACT-deployment strategies.
- Trial name
- IMPACT2 (NCT01130155)
- Where
- Tanzania
- Volunteers
- 33,900 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Latent Tuberculosis Infection (LTBI), Tuberculosis (TB)
Latent Infection Freshmen Tracking for Tuberculosis
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing…
- Trial name
- LIFT-TB (NCT07811518)
- Testing
- tuberculosis preventive treatment
- Where
- 2 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Dermatologic Diseases
Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target
The researchers believe that pro-angiogenic factors are upregulated in a wide range of dermatologic diseases, including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea, and psoriasis.
- Trial name
- NCT00842283
- Testing
- skin tissue sample
- Where
- 2 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine