Clinical trials: Tear Disorder, open to volunteers
Meniscus Rupture, Meniscus Injury
Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy
The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces.
- Conditions
- Meniscus Rupture, Meniscus Injury, Osteoarthritis of Knee
- Trial name
- NCT07079254
- Testing
- Meniscus suture, Partial meniscectomy
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
PPROM
Digital vs. Speculum Exams for PPROM
After preterm prelabor rupture of membranes (PPROM)[breaking of the amniotic sac prior to 37 weeks gestation in pregnancy], patients are recommended for inpatient admission and close monitoring for complications including preterm…
- Trial name
- MOCA (NCT05773014)
- Testing
- Speculum Exams, Digital Exams
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Rotator Cuff Tendinosis
Effects of Rotator Cuff Drills Versus Progressive Resistance Exercises on Chronic Rotator Cuff Tendinopathy
A single-blinded randomized clinical trial was conducted with 30 male overhead athletes (17-35 years) recruited from cricket clubs and sports complexes in Faisalabad.
- Trial name
- NCT07726030
- Testing
- Rotator cuff Drills, Progressive resistance exercises
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Rupture
Are Clinical Outcomes Unchanged by ALL Fixation at 0° or 30° of Knee Flexion in Combined ACL-ALL Reconstruction? Despite Numerous Technical Descriptions of Anterolateral Procedures, There is Limited Knowledge Regarding the Effect of Knee Flexion Angle During Graft Fixation.
This study evaluates whether the knee flexion angle used during fixation of the anterolateral ligament (ALL) affects clinical outcomes in patients undergoing combined anterior cruciate ligament (ACL) and ALL reconstruction.
- Trial name
- ACL ALL (NCT07451743)
- Testing
- anterolateral ligament reconstruction
- Volunteers
- 100 people
- Sponsor
- ASL Lecce
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Meniscus Tear, Meniscus Disorder
Clinical Outcomes, Graft Longevity, and Chondral Protection Following Primary or Revision Meniscal Allograft Transplantation Surgery
The MERCuRE (MEniscus, REstoration, Conservation, and Repair) group is embarking on a 20-year follow-up study to evaluate the clinical outcomes, graft longevity, and chondral protection following primary or revision Meniscal…
- Conditions
- Meniscus Tear, Meniscus Disorder, Patient Satisfaction
- Trial name
- NCT06749431
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Joint Restoration Foundation, Inc.
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Rupture of Anterior Cruciate Ligament, Osteoarthritis
French Prospective Anterior Cruciate Ligament Reconstruction Cohort Study (FAST)
In this study we will examine patients who have undergone anterior cruciate and/or posterior cruciate ligament and/or multi ligaments reconstruction to determine the rate of re-injury, contralateral tear and functional outcomes…
- Trial name
- FAST (NCT02511158)
- Testing
- Ligament of the knee reconstruction
- Where
- France
- Volunteers
- 7,000 people
- Sponsor
- Fonds de Dotation pour la Recherche Clinique en Orthopédie et Pathologie du Sport
Sepsis, PROM, Preterm (Pregnancy)
Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates
Preterm infants are born at less than 37 weeks of pregnancy. Sometimes a break or tear in the fluid filled bag that surrounds and protects the infant during pregnancy leads to an untimely birth.
- Conditions
- Sepsis, PROM, Preterm (Pregnancy), Early-Onset Neonatal Sepsis, Preterm Premature Rupture of Membrane
- Trial name
- SAUNA (NCT06377397)
- Testing
- Antibiotics
- Where
- 9 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Indian Council of Medical Research
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Children Born to Mothers Enrolled in the TOCOPROM Trial
6-year Outcomes in Children After Nifedipine vs Placebo for Preterm Prelabor Rupture of Membranes at 22-33 Weeks
The purpose of this study is to evaluate the neurodevelopment at age 6 of children born to women with preterm prelabor rupture of membranes at 22 to 33 weeks of gestation, after antenatal exposure to nifedipine vs placebo.
- Trial name
- TOCOKIDS (NCT07146451)
- Testing
- Self-administered parental questionnaire, A short psychological assessment performed online
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Dissection Aneurysm, Aortic Dissection Rupture
Effects of Precise Education on Postoperative Discomfort Symptoms in Patients With Aortic Disease Undergoing Endovascular Intervention: a Single-center Randomized Controlled Study
The incidence and severity of post-procedural discomfort were evaluated in patients undergoing endovascular repair for aortic dissection across six symptom-related dimensions: immobilization-related issues, puncture site…
- Conditions
- Aortic Dissection Aneurysm, Aortic Dissection Rupture, Aortic Dissection Involving the Descending Thoracic Aorta
- Trial name
- NCT07362901
- Testing
- postoperative precise education
- Where
- China
- Volunteers
- 132 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neonatal Outcomes, Pregnancy Complications, Infectious
Systematic Screening of Lower Genital Tract Infections
Introduction: The investigation of systematic screening for asymptomatic genital infections in pregnant women is justified by the relevance of these conditions in determining adverse neonatal outcomes, such as prematurity, low…
- Conditions
- Neonatal Outcomes, Pregnancy Complications, Infectious, Premature Birth, Premature Rupture of Fetal Membranes
- Trial name
- NCT07592286
- Testing
- Enhanced microbiological screening, Standard prenatal care
- Volunteers
- 250 people
- Sponsor
- Universidade Federal do Pampa
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Cerebral Arteriovenous Malformations, Ruptured or Unruptured Cerebral Arteriovenous Malformations
Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations
The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous…
- Trial name
- BioMAV (NCT03676868)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Laceration of Skin, Anxiety
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for…
- Conditions
- Laceration of Skin, Anxiety, Discharge Time
- Trial name
- NCT05934669
- Testing
- Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Labral Tear, Femoroacetabular Impingement
Intraoperative Bone Marrow Aspirate Concentrate Injections: Evaluating Outcomes in a Randomized Controlled Trial
The purpose of this study is to see if bone marrow aspirate concentrate (BMAC) used with your hip arthroscopy surgery is a better treatment than just having surgery alone for treatment of labral tears in your hip.
- Trial name
- NCT06750757
- Testing
- Bone marrow aspirate concentrate, Hip arthroscopy
- Volunteers
- 80 people
- Sponsor
- American Hip Institute
Premature Rupture of Fetal Membranes
Intravenous Papaverine for Term Prelabor Rupture of Membranes
This randomized, double-blind, placebo-controlled trial evaluates whether intravenous papaverine, administered as an adjunct to oxytocin, shortens the time to delivery in women with term premature rupture of membranes (PROM).
- Trial name
- NCT07826533
- Testing
- Papaverine
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Wolfson Medical Center
Stickler Syndrome Type 1, Stickler Syndrome Type 2
Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)
The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults.
- Trial name
- OSC/SS (NCT07146516)
- Testing
- Prophylactic (non-invasive) Laser Retinopexy
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Helen Keller Eye Research Foundation