Clinical trials: Therapeutics
Therapeutic Communication
Culturally-Tailored AI Chatbot Simulation for Therapeutic Communication and Empathy in Psychiatric Nursing Students
Therapeutic communication and empathy are core competencies in psychiatric nursing, yet students often have limited opportunities to practise them safely with culturally realistic patients and families.
- Trial name
- AI-CHAT-PSY (NCT07905469)
- Testing
- Culturally-Tailored AI Chatbot Simulation, Instructor-Facilitated Peer Role-Play
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Therapeutic Hypothermia, Neonatal Hypoxic-Ischemic Encephalopathy
Continuous Monitoring of Body Temperature in Neonates During Therapeutic Hypothermia
This prospective observational pilot study aims to evaluate the feasibility, accuracy, and safety of the SteadyTemp® wireless adhesive thermometer for continuous, non-invasive body temperature monitoring in neonates undergoing…
- Conditions
- Therapeutic Hypothermia, Neonatal Hypoxic-Ischemic Encephalopathy, Neonatal Thermal Management
- Trial name
- MonT HT (NCT07756892)
- Testing
- continous temperature measurement
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal
Foot Reflexology in Neonates With Hypoxic-Ischemic Encephalopathy
This randomized controlled trial aims to evaluate the effect of foot reflexology on comfort levels and physiological parameters in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.
- Conditions
- Effect of Reflexology, Hypoxic-Ischemic Encephalopathy, Neonatal, Foot Reflexology, Therapeutic Hypothermia
- Trial name
- NCT07549789
- Testing
- Foot reflexology, Standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Istanbul Nisantasi University
Therapeutic Clown, Relaxation Exercise
The Effect of Progressive Relaxation Exercises With Therapeutic Clown
This study was conducted to investigate the effects of progressive relaxation exercises, performed with the assistance of a therapeutic clown during the pre-operative period, on fear, anxiety and physiological parameters in…
- Conditions
- Therapeutic Clown, Relaxation Exercise, Anxiety, Fear
- Trial name
- NCT07525388
- Testing
- Relaxation exercise group led by a therapeutic clown, The relaxation exercise group led by a research nurse
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Ataturk University
Therapeutic Drug Monitoring (TDM), Tuberculosis
Collect Data From Patients Receiving Standardized Anti-tuberculosis Therapy, Collect Monitoring Data, and Evaluate Treatment Efficacy and Potential Adverse Reactions.
The purpose of this clinical trial is to investigate the correlation between anti-tuberculosis drug concentration monitoring and treatment efficacy and safety through analytical studies.The main questions it aims to answer…
- Trial name
- Tuberculosis (NCT07607288)
- Testing
- Antituberculosis drugs Group
- Where
- China
- Volunteers
- 2,215 people
- Sponsor
- Beijing Chest Hospital
Linezolid, Tuberculosis Multi Drug Resistant Active
Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis Treatment
Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge to global public health. Globally, the World Health Organization (WHO) estimates the number at 400,000 patients with MDR-TB for 2023.
- Conditions
- Linezolid, Tuberculosis Multi Drug Resistant Active, Therapeutic Drug Monitoring (TDM)
- Trial name
- PLOT-TB (NCT07477119)
- Testing
- Linezolid dose personalization based on TDM
- Where
- Guinea
- Volunteers
- 150 people
- Sponsor
- Marco Schiuma
Antiphospholipid Syndrome, Thrombosis
International Registry of Thrombotic APS Patients Treated With Direct Oral Anticoagulants
This registry, currently being established will ensure consistency of data collection and provide safety information in non high-risk APS patients currently on DOACs.
- Conditions
- Antiphospholipid Syndrome, Thrombosis, Anticoagulants Causing Adverse Effects in Therapeutic Use
- Trial name
- OBSTINATE (NCT04262492)
- Testing
- Rivaroxaban
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Stéphane Zuily
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
Developing a Method to Objectively Measure Opioid Analgesia
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and…
- Trial name
- NCT03605966
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Julia Finkel
Staging, Therapeutic Recommendations
Thereapeutic Recommendantion for Children With a Hodgkin Lymphoma
The GFAOP propose a simple and reproducible staging according to clinical, biological and radiological data. Develop standardized but different therapeutic recommendations based on the availability or lack of radiation therapy in…
- Trial name
- GFAOPLH2019 (NCT05407480)
- Testing
- Observational
- Where
- France
- Volunteers
- 250 people
- Sponsor
- French Africa Pediatric Oncology Group
Emotional Dysregulation, Therapeutic Alliance
Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth
Emotional dysregulation in justice-involved youth (JIY) is a condition that significantly impacts young people, their families, and juvenile justice and public health systems.
- Conditions
- Emotional Dysregulation, Therapeutic Alliance, Depression Disorder, Anxiety Disorders
- Trial name
- HEAL-SLOJSC (NCT07364799)
- Testing
- Multi-sensory emotional regulation intervention (Heal)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- SoundHeal
Therapeutic Play, Psychosocial Well-being
Therapeutic Play and Its Effect on Children's Psychosocial Well-Being
The aim of this study was to evaluate the effectiveness of the Therapeutic Play-Based Intervention Programme (TOTEM), which was developed to reduce the negative psychosocial effects of the earthquake in children aged 4-6 years…
- Conditions
- Therapeutic Play, Psychosocial Well-being, Nursing Care
- Trial name
- NCT06845111
- Testing
- Therapeutic play
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Diabetes Mellitus, Type I, Program Evaluation
Evaluation of the Impact of a Therapeutic Education Program for Children With Type 1 Diabetes
The needs of children and teens with type 1 diabetes are very specific and different from the adults with type 1 diabetes. Many organizations such as the World Health Organization or the International Society for Pediatric and…
- Conditions
- Diabetes Mellitus, Type I, Program Evaluation, Therapeutic Education, Children
- Trial name
- PROGETE (NCT02970357)
- Testing
- DIAPASON Questionnaire, WHO-5
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Experience With Therapeutic Plasma Exchange in the Pediatric Nephrology Unit
Experience With Therapeutic Plasma Exchange in the Pediatric Nephrology Unit of Sohag University Hospital
Plasmapheresis also known as a therapeutic plasma exchange (TPE) TPE is an extracorporeal blood purification technique designed for the removal of large-molecular-weight substances.
- Trial name
- NCT07158463
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Sohag University
Emotional States, Therapeutic Communication in Pediatric ICU
Therapeutic Communication Techniques for Children Aged 7-12 in Intensive Care
Summary of the Research Children may need to stay in intensive care for a period of time due to acute or chronic illnesses in their lives.There may be anxiety, fear and concerns in intensive care.
- Conditions
- Emotional States, Therapeutic Communication in Pediatric ICU, Child Emotional Well-being in ICU
- Trial name
- NCT06956586
- Testing
- Therapeutic communication techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Uşak University
Solid Cancer, Bronchial Endoscopy
Impact of Interventional Endoscopy on Quality of Life in Patients With Acute Respiratory Distress Due to Tumor Compression or Obstruction of the Lower Respiratory Tract
Bronchoscopic endoscopy has shown its effectiveness and reliability for the treatment (desobstruction or prothesis) of tumor-induced bronchial obstructions, particularly in the first few weeks.
- Conditions
- Solid Cancer, Bronchial Endoscopy, Therapeutic Bronchofiberscopy
- Trial name
- ENDoRA (NCT07051161)
- Testing
- bronchoscope
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Shortness of Breath, Asthma in Children
The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome
Our study aiming to look in improvement of Pediatric Respiratory Assessment Measure (PRAM) score as a primary outcome. The secondary outcomes involving the need for second step management, need for admission and possible side…
- Conditions
- Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use, Salbutamol Adverse Reaction
- Trial name
- NCT05667727
- Testing
- nebulized epinephrine, Salbutamol
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Medical Speciality Board
Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study
Peppermint oil has shown to be effective in the treatment of Irritable Bowel Syndrome (IBS) symptoms in adults. Few studies of low quality are performed in an paediatric setting.
- Conditions
- Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Child, Adolescent
- Trial name
- MINT (NCT05799053)
- Testing
- Small intestinal release peppermint oil, Peppermint sweets
- Where
- 3 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- St. Antonius Hospital
Type1diabetes, Therapeutic Play
The Effect of Therapeutic Play on Anxiety and Fear Levels in Children With Diabetes
The study will be conducted using a randomized controlled method. Children with type 1 diabetes who are admitted to the Pediatric Endocrinology Service will be divided into two groups by randomization method.
- Conditions
- Type1diabetes, Therapeutic Play, Fear State, Anxiety State
- Trial name
- NCT06418269
- Testing
- Therapeutic Play
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Vascular Access, Vascular Access Complication
Novel Medical Device for Pharmacological Therapy
Background: Different co-creation methods were used to design and prototype a new fixative device for multiple intravenous therapies with the ability to control and identify the pharmacological therapy administered to a patient.
- Conditions
- Vascular Access, Vascular Access Complication, Vascular Access Complications, Catheter Malfunction
- Trial name
- Sechold (NCT06938750)
- Testing
- SECHOLD DEVICE
- Where
- Spain
- Volunteers
- 262 people
- Sponsor
- Fundacion Miguel Servet