Clinical trials: Therapeutics
Autism
the Efficacy of Oral Motor Therapy in Children With Autism
Children with Autism spectrum disorders have speech disorders, which in turn aggravate communication difficulties and lead to an increase in their core symptoms.
- Trial name
- NCT05406076
- Testing
- oral motor therapy, ABA
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Obesity, Lifestyle, Healthy
Twelve-year Follow-up on the Treatment of Obese Pregnant Women (TOP) Study
The participant (both mother and child) in the initial TOP study will be invited to a follow-up study to evaluate the effect of life style intervention during pregnancy on both mother and their offspring 12 years after the…
- Conditions
- Obesity, Lifestyle, Healthy, Diet, Healthy, Follow-up
- Trial name
- TOP12 (NCT05446220)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Burns
Sodic Heparin Effectiveness of the Treatment of Burns
Burns are injuries caused by agents thermal, chemical, electrical or radioactive who act in the tissue lining of the human body and may partially or totally destroy the skin and its annexes, to the deeper layers, as subcutaneous…
- Trial name
- Heparin (NCT00701623)
- Testing
- heparin, folder water
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Azidus Brasil
Gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
- Trial name
- NCT06507280
- Testing
- Periodontal theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer.
- Conditions
- Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor, Central Nervous System Germ Cell Tumor, Choroid Plexus Carcinoma
- Trial name
- NCT04521946
- Testing
- Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- NCT05096273
- Testing
- ReACT
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Child Behavior Disorders
Using Mobile Technology to Enhance Multisystemic Therapy (MST) Outcomes
The goal of the current trial is to assess the feasibility of a newly developed prototype of a cell phone app called VillageWhere.
- Trial name
- VillageWhere (NCT02320903)
- Testing
- VillageWhere App
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Treatment
Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein Glomerulopathy
The purpose of this study is to assess the efficacy and safety of immunoadsorption in the treatment of lipoprotein glomerulopathy.
- Trial name
- NCT00302510
- Testing
- immunoadsorption
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
White Spot Lesion
The Effect of ICON Treatment on WPL With Patients After Fixed Orthodontic Appliances
The aim of this study is to determine the effect of ICON on White spot lesions compared to CPP-ACPF plus.
- Trial name
- NCT03391180
- Testing
- ICON Remineralization, CPP-ACPF
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Healthy, 24-Hour Movement Guidelines
A Mobile App to Improve 24-Hour Movement Guideline Adherence in Preschoolers
The goal of this clinical trial is to evaluate whether a home-based mHealth intervention can improve adherence to the 24-Hour Movement Guidelines in preschool-aged children (3-4 years old) who currently meet 0 or 1 of the…
- Conditions
- Healthy, 24-Hour Movement Guidelines, Feasibility Studies, Sleep
- Trial name
- Shining Star (NCT06667661)
- Testing
- Shining Star mHealth App
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Hand Hygiene, Health Education
Effect of Virtual Reality-Based Handwashing Education on Knowledge, Skills, and Emotional Indicators in Preschool Children
A randomized controlled trial designed to evaluate the effects of virtual reality-based handwashing education on handwashing knowledge, skills, and emotional indicators in preschool children aged 5-6 years.
- Conditions
- Hand Hygiene, Health Education, Infection Prevention
- Trial name
- VR-HAND (NCT07518082)
- Testing
- Virtual Reality-Based Handwashing Education, Traditional Handwashing Education
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Phenylketonuria
Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria
Effect of L-carnitine supplementation on phenylalanine and brain-derived neurotrophic factor levels in infants and children with phenylketonuria L-carnitine is mainly obtained from foods such as red meat and milk that are limited…
- Trial name
- NCT06901323
- Testing
- L-carnitine
- Where
- Egypt
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lateral Condyle Fractures,Humerus,JakobⅡ Classification,Reduction
Surgical Treatment for the Displaced JakobⅡ Classification Humerus Lateral Condylar Fractures in Children
Multi-center Study on Surgical Treatment for the Displaced JakobⅡ Classification Humerus Lateral Condylar Fractures in Children.
- Trial name
- JCHLCF (NCT03447496)
- Testing
- Closed reduction, Open reduction
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shunyou Chen
Tuberculosis, Pulmonary
Post TB Sequelae Study
The goal of this prospective cohort study is to learn about the long-term health effects of tuberculosis (TB) in children, adolescents, and adults who have completed standard TB treatment in Bangladesh.
- Trial name
- NCT06744179
- Testing
- echocardiography, chest x-ray, full blood count , SGPT, lipid profile, HbA1C, AQ20 questionnaire, mmRC dyspnoea scale, Duke activity status index, COPD assessment test, Age and stage questionnaire
- Where
- Bangladesh
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Teledentistry, Orthodontics, Interceptive
Teleorthodontics Versus Conventional Follow-up During Early Interceptive Orthodontic Treatment in Children
The goal of this clinical trial is to learn if teleorthodontic remote monitoring is as effective as traditional in-office care for children undergoing Phase I expansion therapy.
- Conditions
- Teledentistry, Orthodontics, Interceptive, Palatal Expansion Technique
- Trial name
- NCT07611227
- Testing
- Remote Monitoring via Smartphone Application, Conventional Monitoring
- Where
- Saudi Arabia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Murad Alrashidi
Medical Scribes
Evaluation of the Use of Medical Scribes in VAMC Emergency Departments and Specialty Care Clinics
Background and study aims: Medical scribes are trained paraprofessionals that assist providers with documenting patient encounters.
- Trial name
- NCT04154462
- Testing
- Scribes
- Where
- 12 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Injury;Sports, Biomechanical Lesions
Detection of Neuromuscular Deficits in Uninjured Youth Basketball Players
Basketball is an impact, coordination-opposition sport with continuous contact among players and it is considered a sport of medium-high injury incidence.
- Conditions
- Injury;Sports, Biomechanical Lesions, Musculoskeletal Injury
- Trial name
- DPL (NCT04796753)
- Testing
- Basketball Injury Defense
- Where
- Spain
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Pulp Necrosis, Periapical Lesion
Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth
This study evaluates success rate of non vital mature anterior teeth with periapical lesion treated by regenerative endodontic protocol in single visit versus two visit technique.
- Conditions
- Pulp Necrosis, Periapical Lesion, Anterior Teeth
- Trial name
- NCT03717337
- Testing
- Single visit pulp regeneration, Two visit pulp regeneration
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Transverse Friction Massage
Effects of Deep Friction Vs Stretching Techniques
Flexibility, agility and muscle strength are key factors to either win or lose a game. Recently the effect of a new technique, deep transverse friction massage (DTFM), on muscle extensibility, strength and agility and injury…
- Trial name
- NCT03540888
- Testing
- Deep transverse Friction Massage, Dynamic stretching intervention, Static stretching intervention
- Where
- Lebanon
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mohammed Ali FAKHRO, DPT
Quality of Life, Injection Site Reaction
Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
This study is a prospective, randomized clinical trial. During this study, participants will be randomly assigned to receive quadrivalent inactivated influenza vaccine (IIV4) and mRNA COVID-19 vaccine either simultaneously or…
- Conditions
- Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
- Trial name
- NCT05028361
- Testing
- mRNA COVID-19, IIV4
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Duke University
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