Clinical trials: Therapy, Directly Observed
HIV
Emtricitabine/Tenofovir Alafenamide as Salvage ART
Background: HIV attacks the immune system. Antiretroviral therapy (ART) is a combination of drugs used for treating HIV infection. For some people, ART drugs stop working against their HIV.
- Trial name
- NCT02556333
- Testing
- FTC/TAF
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Food Incentives for TB Treatment Compliance in East Timor (FITTCET)
This study will examine whether food is a cost-effective method for improving treatment compliance for TB patients in Timor Leste.
- Trial name
- NCT00192556
- Testing
- food
- Where
- Australia
- Volunteers
- 270 people
- Sponsor
- Menzies School of Health Research
Electrode Site Reaction, Therapy
Functional Electrostimulation on the Upper Lip in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the body, triggering an inflammatory response. A study comparing multifield FES and conventional FES on upper extremity motor skills and functional…
- Conditions
- Electrode Site Reaction, Therapy, Directly Observed Therapy
- Trial name
- EM/2024 (NCT06638775)
- Testing
- Fesia Grasp, GLOBUS ELITE
- Volunteers
- 30 people
- Sponsor
- Universidad de Burgos
HIV Infections
Directly Observed Therapy in HIV Infected Adolescent Focus Groups
The purpose of this study is to help researchers use information from HIV infected adolescents to design a directly observed therapy (DOT) program that will help adolescents take their anti-HIV medications correctly.
- Trial name
- NCT00079729
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Medication Adherence, Liver Transplantation
mDOT for Immunosuppressant Adherence in Adolescent Liver Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent liver transplant recipients.
- Trial name
- NCT03781830
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
HIV
Modified Directly Observed Antiretroviral Therapy
M-DART Study is a randomized clinical trial comparing the effectiveness of a home-based modified directly observed antiretroviral (ART) treatment strategy to clinic-based standard of care in patients with HIV/AIDS in Port…
- Trial name
- M-DART (NCT01985269)
- Testing
- Home visits
- Where
- Kenya
- Volunteers
- 511 people
- Sponsor
- Moi University
Asthma in Children, Directly Observed Therapy
Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes
Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency…
- Trial name
- NCT06539312
- Testing
- APP assessment and management of asthma
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- State University of New York at Buffalo
Asthma in Children
vDOT for Newly Diagnosed Pediatric Asthma
The goal of this research study is to compare the impact of video directly observed therapy on inhaler technique accuracy with participants receiving video directly observed therapy vs.
- Trial name
- NCT05120323
- Testing
- vDOT Intervention Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Arkansas Children's Hospital Research Institute
HIV Infections
Directly Observed Therapy for HIV Infected Adolescents
Adherence to a doctor-prescribed anti-HIV drug regimen is crucial in the management of HIV infection. In previous studies with tuberculosis patients, directly observed therapy (DOT), a strategy in which patients are observed…
- Trial name
- NCT00259389
- Testing
- Directly observed therapy (DOT)
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Transplant Rejection, Immune Suppression
Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients
We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR)…
- Conditions
- Heart Transplant Rejection, Immune Suppression, Pediatric Heart Transplant, Medication Nonadherence
- Trial name
- NCT05732779
- Testing
- DOT intervention
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
HIV Infections
A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
Anti-HIV drug therapy works best when the drugs are taken exactly as prescribed by a doctor. Because anti-HIV therapy often involves multiple drugs, some people have difficulty taking them all correctly.
- Trial name
- NCT00036452
- Testing
- lopinavir/ritonavir, emtricitabine, stavudine
- Where
- 29 sites in United States, Puerto Rico and 1 more
- Volunteers
- 402 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Iron Deficiency Anemia (IDA)
Directly Observed Iron Supplementation to Treat Anemia
India continues to be one of the countries with very high prevalence of anemia. In fact, National Family Health Survey-3 (NFHS-3,2005-06) revealed increasing prevalence of anemia in women and children, since NFHS-2 in 1998-99.
- Trial name
- DOHBIT (NCT01129843)
- Testing
- Directly observed home based daily iron therapy
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Build Healthy India Movement
Tuberculosis, Drug-resistant Tuberculosis
An Evaluation of Traditional Directly Observed Therapy (DOT) and Electronic DOT for TB Treatment
This study is a U.S.-based, 1 site (with 4 clinical settings), randomized controlled trial (with funding from the Centers for Disease Control and Prevention's (CDC) Antibiotic Resistance Solutions Initiative) that will be…
- Conditions
- Tuberculosis, Drug-resistant Tuberculosis, Adherence, Medication, Adherence, Patient
- Trial name
- NCT03266003
- Testing
- Electronic DOT, In-person DOT
- Where
- 4 sites in United States
- Volunteers
- 216 people
- Sponsor
- Centers for Disease Control and Prevention
Therapy, Directly Observed
Acceptance and Commitment Therapy and Test Anxiety
The aim of this study is to evaluate the effect of acceptance and commitment therapy-based psychoeducation on test anxiety, study skills and psychological flexibility on adolescents.
- Trial name
- NCT05665933
- Testing
- ACCEPTANCE AND COMMITMENT THERAPY-BASED PSYCOEDUCATION
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
Sickle Cell Disease
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites.
- Trial name
- ADHERE (NCT06264700)
- Testing
- Video Directly Observed Therapy (VDOT), Health Reminder Tip Alerts
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nationwide Children's Hospital
Medication Adherence, Kidney Transplant
A Pilot Study of mDOT for Immunosuppressant Adherence in Adolescent Kidney Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent kidney transplant recipients.
- Trial name
- NCT03504137
- Testing
- mHealth Intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Tuberculosis, Pulmonary
Cost-effectiveness of Two Forms of DOTS in a Demonstration Area of the DOTS Strategy in Colombia
Tuberculosis ( TB ) remains a major global public health problems and actions to ensure the diagnosis and complete treatment of all cases is the priority for the control of this disease.
- Trial name
- DOTS (NCT01945905)
- Testing
- Intramural, Extramural
- Where
- Colombia
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Fundación FES
Hepatitis C
Pilot Trial of Directly Observed Anti HCV Therapy & Contingency Management in a Population on Opiate Substitute Therapy
DOT-C is a cluster randomised trial of a pharmacist-led, directly observed anti HCV therapy pathway versus the conventional care pathway within community pharmacies.
- Trial name
- DOT-C (NCT03483818)
- Testing
- Assessment & Treatment of HCV infection with oral antivirals
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- NHS Tayside
Tuberculosis Active
Video-observed Therapy for Active Tuberculosis: a Feasibility Study
Tuberculosis (TB) is still present in Switzerland, and concerns mainly foreign-born subjects. Monitoring compliance to treatment by Directly Observed Therapy (DOT) is strongly encouraged by the World Health Organization (WHO).
- Trial name
- NCT06574529
- Testing
- Video-observed therapy (vDOT)
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- Ligue Pulmonaire Genevoise
Tuberculosis, Pleural Effusion
Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis.
- Trial name
- NCT01560078
- Where
- India
- Volunteers
- 360 people
- Sponsor
- All India Institute of Medical Sciences